Penfluridol

Uses	Treatment of schizophrenia, depression, and bipolar disorder
Therapy	Anti-Psychotics
Side Effects	Increase in blood prolactin level, constipation, weight gain, dryness in mouth, muscle stiffness, orthostatic hypotension or immediate blood pressure reduction on standing, sleepiness, tremors, abnormality of voluntary movements, urinary retention

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Molecule Description

Penfluridol is a medicine to treat schizophrenia. In addition, it is sometimes used to treat depression and bipolar disorder. It improves a person's capacity to think, feel, and act by altering thinking and elevating mood.

Uses

As per CDSCO, Penfluridol treats schizophrenia, depression, and bipolar disorder.

Contraindications

When should one not use Penfluridol

If you have preexisting central nervous system or CNS depression
If you are in the stage of a coma
Previous allergy to any components of Penfluridol

Side effects

Common side effects of this drug are:

Abnormality of voluntary movements
Urinary retention
Increase in blood prolactin level
Constipation
Weight gain
Dryness in mouth
Muscle stiffness
Tremors

Precautions and Warnings

Pregnancy

It's possible that using Penfluridol while pregnant is dangerous. Animal research has shown harmful impacts on the growing foetus, considering the absence of human studies. Before recommending Penfluridol to you, your doctor will determine the advantages and possible hazards. Please seek medical advice.

Breast Feeding

If you're breastfeeding, don't take Penfluridol unless it's required. While using this prescription, seek medical advice about the risks and benefits.

Driving

Because this prescription may induce dizziness and tiredness, you should not drive or do anything else that demands mental attention until you realise how it affects you.

Alcohol

Due to the increased risk of side effects, including dizziness, sleepiness, and problems concentrating, don't drink alcohol while consuming Penfluridol.

Other General Warnings

Talk to your doctor if

You must note your weight while consuming Penfluridol since it might cause weight gain.
You must carefully take Penfluridol if you have low potassium levels in the body. Take the medicine only after the potassium deficiency has been corrected.
You must seek medical assistance when you notice involuntary lip, tongue, and facial movements. In such circumstances, a gradual dose decrease or withdrawal of Penfluridol should be taken.
You must consume Penfluridol with caution if you have liver problems. While taking medicine, it's essential to keep an eye on your liver function tests.
You should consume Penfluridol carefully if you have neuroleptic malignant syndrome.
You must consult your healthcare professional before consuming Penfluridol if you possess a seizure disorder. It is due to the increased danger of the patient's condition intensifying. Report any odd symptoms to your doctor as soon as possible.
You should be cautious if you have a cardiac illness, including extended QT, abnormal heart rhythm, and so on.

Mode of Action

How Does It Work?

Penfluridol is an antipsychotic medication. It works by preventing dopamine, a brain chemical that influences thoughts and emotions, from acting. It binds to dopamine receptors in the brain and relieves symptoms of mental conditions like schizophrenia and bipolar disorder.

Interactions

Interactions with other medicines

There is an interaction between Penfluridol and the following medicines. It might cause muscle stiffness, sleepiness, weight gain, tremors, and urinary retention when interacted with:
Central nervous system agents, including Levodopa
Tricyclic Antidepressants
Dopamine receptor agonists like Bromocriptine
Opioids
Antihypertensives
Anticonvulsants such as Carbamazepine

Interactions with food items

There is no interaction between Penfluridol and food. However, seek medical advice before consuming the medicine.

Dosage

Overdose

Overdosing on Penfluridol can cause weakness, irregular heartbeat, dilated pupils, and loss of consciousness. In the event of Penfluridol overdose, get medical help right away. If the sufferer has passed out, had a seizure, is having problems breathing, or cannot be roused, go to a local hospital right away.

Missed a Dose

As fast as you realise, complete the overdue dosage. Then, ignore the delayed dose and return to your usual dosing routine when the next dosage is approaching. To compensate for an overdue dosage, do not consume a double amount.

Frequently Asked Questions (FAQs)

The doctor should select the dosage for this medicine depending on your medical history and present condition. Take it exactly as prescribed by your doctor.

Because of the medicine's rebound impact, it's usually a good idea to go off such medications gradually in some circumstances. In addition, it's a good idea to contact your doctor for professional guidance on your health, medicines, and other recommendations to help you maintain a stable health.

Individuals with a history of epilepsy, previous cardiac disease, decreased magnesium or potassium levels in the blood, thyroid hormone deficit, the elderly must consume Penfluridol cautiously.

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References:

PubChem. Penfluridol [Internet]. Nih.gov. [cited 2026 Jun 13].

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