Pemetrexed

Uses	Lung cancers
Therapy	Anti-Neoplastic
Side Effects	Fever, infection, vomiting, nausea, diarrhoea, loss of appetite, hair loss, loss of blood counts

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Molecule Description

Pemetrexed is an anti-cancer medicine. It may be administered alone or in combination with other medications, such as cisplatin, for the treatment of various types of lung cancer. It is recommended to consult your doctor if you are pregnant or breastfeeding before receiving this medicine. This medicine is administered by a healthcare professional and should be given only by your doctor in a healthcare setting.

Uses

Pemetrexed may be used for different types of lung cancer.

Contraindications

When should one not use Pemetrexed

If you are allergic to pemetrexed or any other ingredients present in this medicine.
If you are breastfeeding
If you received or plan to receive vaccine against yellow fever.

Side effects

Common side effects of this drug are:

Fever
Infection
Vomiting
Nausea
Diarrhoea
Loss of appetite
Hair loss
Loss of blood counts

Precautions and Warnings

Pregnancy

It is unknown or having limited data about the use of this medicine in pregnant women or pregnancy confirmed women. However, like other anti-cancer medicines this medicine may also show birth defects or genetically damaging effects. Consult your doctor before you receive this medicine.

Breast Feeding

It is unknown or having limited data about the use of this medicine that it may or may not excrete from the breast milk. It is recommended to consult your doctor before receiving this medicine.

Driving

This medicine may cause fatigue. It is recommended to avoid activities like driving or operating machinery while you receive this medicine.

Alcohol

Alcohol is processed by an organ (liver) in the body and liver is the main source for anti-cancer medicines to metabolize.Alcohol consumption may impair the function of liver and increase the risk of adverse effects. It is strictly not recommended to consume alcohol while receiving this medicine.

Other General Warnings

Talk to your doctor if

You have kidney or liver problems
You have any history of radiation therapy or planning to undergo it
You are vaccinated or planned for any vaccination
You have any heart problems
You have any excess fluid present in and around lungs. If you are unsure consult your doctor.
Pemetrexed is not relevant to use in children
It is recommended to use effective contraceptive measures to avoid the risk of birth defects. It is recommended to matured males that not to become a father during the treatment and thereafter, up to 6 months.
You have a known history of deficiency of folate and vitamin B12
You have lower blood counts. If you are unsure, then consult your doctor.

Mode of Action

How Does It Work?

Pemetrexed is a cytotoxic drug. This means it will directly interfere with the process of cancer cell growth and its rapid production of cancer cells and stop the spread of cancer. It may also help decrease the size of tumors.

Interactions

Interactions with other medicines

Some medicines can affect the way Pemetrexed works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction. Also, you should inform your doctor if you have a planned surgery or vaccination scheduled.
Especially if you take/receive/administer medicines like ibuprofen for pain, other pain medicines, penicillin, probenecid etc.
The use of Pemetrexed may have an increased risk of clot formation. Your doctor may prescribe anti-clot formation medicines to eliminate the risk.

Dosage

Overdose

The possibility for the overdose is unlikely as this medicine will be administered/given by a healthcare professional. If any unusual signs and symptoms like rashes, fever, diarrhoea, etc experienced, then immediately inform your doctor.

Missed a Dose

The possibility for the missing a dose is unlikely as this medicine will be administered by a healthcare professional.

Frequently Asked Questions (FAQs)

It is reported that there might be a possibility that male patient who is receiving this medicine may cause irreversible infertility. Your doctor may advise you for counselling on sperm storage before initiating the treatment.

This medicine is used in the treatment of different forms of lung cancers.

This medicine contains Pemetrexed as the active ingredient.

This medicine is not recommended for use in children. Consult your doctor before using it in the elderly population (65 years and above).