Pazopanib

Uses	Kidney cancer and soft-tissue sarcoma
Therapy	Anti-Neoplastic
Side Effects	Diarrhoea, nausea or vomiting, changes in hair colour, and loss of appetite.

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Molecule Description

Pazopanib is used in adults to treat advanced kidney cancer. It is also prescribed for certain soft-tissue sarcomas, which are cancers that develop in supportive tissues, such as muscles, fat, and blood vessels. Pazopanib works by blocking specific proteins that contribute to the growth and spread of cancer cells. Common side effects of this medicine include diarrhoea, nausea or vomiting, changes in hair colour, and loss of appetite. Your healthcare provider will conduct blood tests to monitor your liver function before and during Pazopanib treatment. Pazopanib is not recommended for individuals under 18 years of age. Before taking this medication, inform your doctor if you have a history of heart disease, liver, or kidney problems, or if you are currently using any medications to treat infections. Many other drugs can interact with this medication, so it's essential to inform your healthcare team about all the medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. It is important for both males and females to use effective contraception during treatment to prevent pregnancy.

Uses

Pazopanib is used in the treatment of kidney cancer and soft tissue sarcoma, which is a rare type of cancer originating in the body's soft tissues, including muscles, tendons, fat, blood vessels, and nerves.

Contraindications

When should one not use Pazopanib

If you are allergic to pazopanib or any of the other ingredients of this medicine.

Side effects

Common side effects of this drug are:

Diarrhoea Nausea or vomiting Change in hair colour Loss of appetite

Precautions and Warnings

Pregnancy

Pazopanib is not recommended for pregnant women, as its effects during pregnancy are unknown.

Breast Feeding

Avoid breast-feeding while on Pazopanib, as it's unclear if its ingredients enter breast milk. Consult your doctor regarding this.

Driving

Pazopanib may cause side effects impacting your ability to drive or operate machinery. Avoid these activities if you feel dizzy, tired, weak, or have low energy.

Alcohol

It is advisable to avoid consuming alcohol while on Pazopanib, as it may increase the risk of side effects.

Other General Warnings

Talk to your doctor if

You suffer from heart disease.
You have liver disease.
You have experienced heart failure or a heart attack.
You have previously had a collapsed lung.
You have dealt with bleeding issues, blood clots, or arterial narrowing.
You have experienced gastrointestinal problems, such as perforation (a hole) or a fistula (an abnormal passage between intestinal parts).
You have thyroid issues.
You have kidney function problems.
You currently have or have had an aneurysm (the enlargement and weakening of a blood vessel wall) or a tear in a blood vessel wall.

Mode of Action

How Does It Work?

Pazopanib inhibits the formation of new blood vessels that tumours require for growth. It does this by blocking specific proteins (tyrosine kinases), including VEGFRs and PDGFRs, which are essential for the formation of new blood vessels. By blocking these proteins, the medication can slow or halt the progression of the disease.