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Oxazepam

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Molecule Summary

Uses
Anxiety, Anxiety associated with alcohol withdrawal, Anxiety associated with depression
Therapy
Anti-Anxiety
Side Effects
Blurred speech, Change in sex drive, Balancing problems, Suicidal thoughts, Seizures, Sleepiness, Lightheadedness, Dry mouth, Weakness.
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Molecule Description

Oxazepam is a prescription medicine used for managing anxiety and panic disorders. It is a tranquilliser medicine (used to reduce symptoms of anxiety). This medicine works by balancing the chemical substances in the brain, which slows the activity in the brain and relaxes the overworked nervous system.

Uses

  • Oxazepam can be used for:
  • The management of symptoms of anxiety disorder.
  • Treating anxiety associated with depression.
  • The treatment of anxiety caused by alcohol withdrawal (symptoms that can develop in people who stop drinking alcohol after drinking large quantities for a long time).

Contraindications

When should one not use Oxazepam

  • If you have an allergic reaction to any component of Oxazepam
  • If you have any history of addiction to recreational drugs or alcohol, Oxazepam has habit-forming potential.
  • If you have respiratory depression (steady decline of breathings) or a head injury. This medicine increases the risk of life-threatening breathing problems.
  • If you are using antidepressant medications.
  • If you are pregnant, Oxazepam can cause congenital disabilities in unborn babies, especially in the first trimester.
  • If you are breastfeeding, this can have adverse effects on newborn babies.
  • If you have closed-angle glaucoma, an eye disorder, Oxazepam can increase the fluid pressure in the eye.
  • If you notice having mood changes, suicidal or other harmful thoughts.
  • If you are taking other medications that have narcotic or opioid ingredients.
  • If you are younger than the age of 18, this medicine is not recommended.
  • If you have breathing problems like asthma, sleep apnea, etc.
  • If you are at risk of falling most of the time.

Side effects

Common side effects of this drug are:

  • Lightheadedness
  • Blurred speech
  • Sleepiness
  • Dry mouth
  • Weakness
  • Change in sex drive

Precautions and Warnings

Pregnancy

Pregnancy

No, Oxazepam is unsafe during pregnancy. Some studies have shown a definite risk to the unborn baby of developing congenital malformations, especially when used in the first trimester. Sometimes doctors may prescribe it for life-threatening conditions if they think the benefits outweigh the risks. Do not take Oxazepam without consulting your doctor.

Breast Feeding

Breast Feeding

You should consult your doctor before taking Oxazepam, as it can be unsafe during breastfeeding. There is limited data available on the effects of this medicine on a breastfeeding baby. Some studies suggested that the medicine may pass into the milk and cause unwanted effects on the baby like excess drowsiness, lethargy, etc. Babies must be closely monitored in such cases.

Driving

Driving

No, do not drive after taking Oxazepam. The medicine can cause side effects like drowsiness, lightheadedness, and blurred or double vision that can impair your ability to drive.

Alcohol

Alcohol

No, you cannot consume alcohol with Oxazepam. It can interfere with the effectiveness of Oxazepam medication and cause exaggerated side effects.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are trying to get pregnant.
  • You are using medication for fungal infections.
  • You have a seizure disorder and are under antiepileptic medication.
  • You are using any vitamin, herbal medicines or supplements; they may interact with this medicine.
  • You have a history of lung, kidney or liver disorders; the dose needs adjustment.
  • You are an elderly patient over 65 years of age; high doses may cause serious adverse effects due to the slow metabolism.
  • You are planning to have a medical, surgical or dental procedure.
  • You have withdrawal symptoms like sweating, tremors, nausea, agitation, and confusion.

Mode of Action

How Does It Work?

Oxazepam belongs to the benzodiazepine class of medicines. This medication binds to certain receptors in the brain that increase the activity of GABA (Gamma-aminobutyric acid), a chemical messenger in the brain. Increased activity of GABA causes suppression of the excessive and abnormal activity of nerve cells. This results in a relaxing and calming effect. The medication also has sedation effects. These properties help in managing anxiety-related symptoms.

Interactions

Interactions with other medicines

  • If you take antifungal medication (like itraconazole or ketoconazole), do not mix them with Oxazepam.
  • Taking antidepressants or mood-elevating medications like fluoxetine or desipramine can cause adverse and contrasting effects when mixed with Oxazepam.
  • Oxazepam can reduce the effect of oral contraceptives or birth control pills.
  • Do not mix Oxazepam with antihistamines (allergy medication), as it can increase the effects of drowsiness, fatigue, etc.
  • Do not take other sedative medications or Benzodiazepine like alprazolam, etc., with Oxazepam; it can exaggerate the side effects.

Interactions with food items

  • Avoid having grapefruit and its juice; it reduces the effect of Oxazepam medicine.
  • Avoid eating St John's wort (a flower), the medicinal herb that treats depression, with Oxazepam medicine.

Dosage

Overdose

An overdose of Oxazepam can cause symptoms like drowsiness, loss of consciousness, problems with coordination, confusion, difficulty speaking, liver problems (yellowing of eyes and skin), and seizures. If you overdose on this medicine and experience any of these symptoms, immediately seek emergency medical treatment from a nearby hospital.

Missed a Dose

If you have missed a single dose of Oxazepam, take it as soon as possible. If you remember missing a dose of Oxazepam when it's already time to take the next one, then skip the missed dose and take the next dose. Do not take two doses together as it can cause adverse effects. Talk to your doctor if you are confused about the dosage or missed more than a few doses.

Frequently Asked Questions (FAQs)

Yes, Oxazepam can cause weight gain. It can also induce weight loss. Its effects on weight vary from person to person. If you are gaining weight, try to be more physically active and eat a healthy diet.

Do not use Oxazepam without consulting your doctor for seizure disorders. The medication interaction can worsen the condition or cause side effects. Do not stop using this medicine suddenly without talking to your doctor, as it can cause withdrawal symptoms and precipitate seizures.

No, Oxazepam cannot treat depression. If you are suffering from depression, consult your doctor for the appropriate treatment.

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