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Molecule Description

Nateglinide is an oral anti-diabetic medicine which helps to lower your blood su...
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    Side effects
    Precautions and Warnings
    Mode of Action
    Dietary Restrictions

Uses of Nateglinide

Type II diabetes

Contraindications of Nateglinide

When should one not use Nateglinide

  • Type 1 diabetes
  • Liver disease
  • Kidney disease
  • Diabetic ketoacidosis
  • Allergy to this medicine

Side effects of Nateglinide

Common side effects of this drug are:

  • Low blood glucose level (if meal is delayed or skipped)
  • Weight gain
  • Allergic reaction
  • Loose stools
  • Abdominal discomfort

Precautions and Warnings of Nateglinide



Can I take Nateglinide during pregnancy?
It is not recommended for pregnant women, consult your doctor for safer alternatives.

Breast Feeding

Can I take Nateglinide while breastfeeding?
It is not secreted into breast milk. But still, do not breastfeed while you are taking Nateglinide without consulting your doctor because this medicine has the potential to cause low blood sugar in breastfed infants.


Can I drive if I have consumed Nateglinide?
You may experience blurred vision, drowsiness or dizziness due to extremely low or high blood sugar level. So it is advised not to drive or use machinery.


Can I consume alcohol with Nateglinide?
It is not recommended to consume alcohol while taking this medicine as alcohol may affect blood glucose levels in patients with diabetes and interferes with the activity of Nateglinide.

Other General Warnings

Talk to your doctor if
  • Be very careful about symptoms of low blood sugar like sweating, anxiety, fast heartbeat, headache, intense hunger, restlessness, dizziness, irritability. If you experience these, immediately ext suga...
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  • Eat something sweet as soon as possible. If the symptoms persist even after this, seek emergency medical help
  • Tell your doctor if:
  • You have an allergy to this medicine
  • You have liver or kidney disease
  • Your body does not produce enough red blood cells
  • All your ongoing medications

Mode of Action of Nateglinide

How Does It Work?

Nateglinide works by blocking potassium channels, results in stimulating the release of insulin from the pancreas and lowers blood glucose levels.

Interactions of Nateglinide

Interactions with other medicines

  • Medicines used to control high blood pressure
  • Barbiturates
  • Carbamazepine
  • Chlorpromazine
  • Olanzapine
  • Clarithromycin
  • Erythromycin
  • Aspirin
  • Clopidogrel
  • Cyclosporine
  • Gemfibrozil
  • Ketoconazole and Itraconazole
  • Rifamycins and Rifabutin

Interactions with food items

Grapefruit or grapefruit juice.

Dietary Restrictions of Nateglinide

You should avoid trans fats, white bread, pasta and rice, fruit-flavored yogurt, sweetened breakfast cereals, flavored coffee drinks, grapefruit, honey, etc.

Dosage of Nateglinide


If you happen to take an excessive dose of this medicine, it may lead to a drop in your blood sugar, leading to symptoms of hypoglycemia such as cold sweats, increase in heart rate, tremors, anxiety a...
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Missed a Dose

If you missed a dose, take the next dose as usual but do not double the dose.

Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What precautions should one follow before starting treatment?

A: Nateglinide should be used with caution in elderly patients because they may be more sensitive to it. Nateglinide may cause changes in your blood sugar levels. One should be aware of the symptoms of high (hyperglycaemia) or low (hypoglycaemia) blood sugar episodes and be prepared to treat them.

Q: Can Nateglinide be taken during pregnancy or lactation?

A: Nateglinide is not safe in pregnancy. Consult your doctor before starting treatment. However, the patient is generally put on insulin therapy instead. It is not secreted into breast milk. But still, avoid breastfeeding while you are taking Nateglinide without consulting your doctor.

Q: What precautions should one take before going out for travel?

A: One should always carry some glucose, sugary food or fruit juice in case if experiences symptoms of low blood glucose level (hypoglycaemia ) such as cold sweats, increase in heart rate, tremors and anxiety.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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