Mycophenolate Mofetil

Q: What should I discuss with my healthcare expert before taking Mycophenolate Mofetil?

You must inform your doctor if: , You are allergic to Mycophenolate Mofetil, Mycophenolic Acid or Polysorbate 80 , You are suffering from any infection like viral, fungal or bacterial , You have complaints of: , Stomach, intestine, stomach ulcers , You are pregnant, nursing or planning for pregnancy , You suffer from conditions like phenylketonuria, Lesch-Nyhan syndrome or Kelley-Seegmiller syndrome or liver disorders , You must also provide information on all your ongoing medications

Molecule Description

Mycophenolate Mofetil is a drug to suppress the immunity of the body. Because t

he immunity of the body treats the new organ as a foreign body, an immunosuppressant has to be given after transplant that prevents your body from rejecting an organ like the liver, heart or kidney.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Mycophenolate Mofetil

Mycophenolate Mofetil is used in cases of organ transplants where there is a risk of the body rejecting the new organ considering it to be a foreign body. The transplant organs include the following:
Liver
Kidney
Heart
Bone marrow
Limb
Intestine
Pancreatic cells
Its use is being extended to certain serious condition in which the body attacks own cells (autoimmune diseases)

Contraindications of Mycophenolate Mofetil

When should one not use Mycophenolate Mofetil

Progressive disease associated with white matter of the brain
Skin cancer
Shingles without a normal immune system
Herpes simplex infection
Stomach or intestinal ulcer
Disease caused by cytomegalovirus infection or BK virus
Liver problem
Bleeding of the stomach or intestines
Severe renal impairment
Opportunistic fungal infection
Severe infection
Malignant lymphoma
Malignant tumor or cancer
A rupture in the wall of the stomach or intestine
Constitutional aplastic anemia
Decreased function of bone marrow
Severely decreased levels of white blood cells in the blood
Reduced neutrophils (a type of white blood cell)

Side effects of Mycophenolate Mofetil

Common side effects of this drug are:

Mycophenolate Mofetil can decrease the immune response of the body and can trigger certain infections like herpes, hepatitis and brain infections
It can also reactivate certain infections which were earlier under control, for example, hepatitis B, C and HIV
Allergic reaction: difficulty in breathing, rash, swelling of the face, mouth lips, tongue
Fever, weakness, flu-like symptoms, mouth ulcers
Sore throat or pain, runny or blocked nose, headache, earache
Confusion, unable to think clearly, disinterest in work
Nausea, vomiting, diarrhea, weight loss, stomach pain, mouth dryness
Muscle weakness to body
New bump on the skin that has changed color or size
Swelling, pain, redness, discharge from skin or wound
Painful stools or bloody
Coughing or vomiting blood
Bleeding through the nose or gums
Serious side effects includes:
Chest pain, irregular pulse
Blurred vision, difficulty in breathing, dizziness
Pain, burning or bloody urine

Precautions and Warnings of Mycophenolate Mofetil

Pregnancy

Can I take Mycophenolate Mofetil during pregnancy?

Mycophenolate Mofetil can cause birth defects or miscarriage if taken during pregnancy, especially during the first three months. It is necessary to avoid pregnancy while you are taking this medicine and for at least six weeks of discontinuation.

Breast Feeding

Can I take Mycophenolate Mofetil while breastfeeding?

Do not take this medicine if you are breastfeeding as a small amount of the medicine can pass into the mother’s milk.

Driving

Can I drive if I have consumed Mycophenolate Mofetil?

Do not drive unless you feel well.

Alcohol

Can I consume alcohol with Mycophenolate Mofetil?

Avoid intake of alcohol while on treatment with this medicine as it may lead to cause side effects.

Other General Warnings

Talk to your doctor if

You should not donate blood during treatment with this medicine at least for six weeks after stopping treatment. Men should not donate semen during treatment with this medicine for at least 90 days af...
Read more
Mycophenolate Mofetil and Mycophenolic Acid are not absorbed equally
Hence, it is essential that you are careful about the prescribed brand and not mix one for the other

Mode of Action of Mycophenolate Mofetil

How Does It Work?

It helps in blocking the chemicals for proliferation and acts as a suppressant to immunity.

Interactions of Mycophenolate Mofetil

Interactions with other medicines

The following medicines are known to interact with Mycophenolate Mofetil. Hence your doctor needs to know about all the medicines you use
Antiviral medicines: Acyclovir, Ganciclovir, Valacyclovir
Antibiotics: Amoxicillin, Ciprofloxacin, Metronidazole, Norfloxacin, Rifampin
Cholestyramine
Sulfa medicine
Antacids: Lansoprazole, Pantoprazole
Azathioprine

Interactions with food items

No other food interactions are reported.

Dosage of Mycophenolate Mofetil

Overdose

Inform your doctor immediately in case of overdose. Overdose symptoms may include deficient immunity and vulnerability to infections, diarrhea, stomach pain, easy bruising or bleeding, dark urine or y...

Missed a Dose

Take the missed dose as early as you remember. If the time for the next dose is close, skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Abhishek B L

MBBS, MD (Pharmacology)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What should I discuss with my healthcare expert before taking Mycophenolate Mofetil?

You must inform your doctor if:
You are allergic to Mycophenolate Mofetil, Mycophenolic Acid or Polysorbate 80
You are suffering from any infection like viral, fungal or bacterial
You have complaints of:
Stomach, intestine, stomach ulcers
You are pregnant, nursing or planning for pregnancy
You suffer from conditions like phenylketonuria, Lesch-Nyhan syndrome or Kelley-Seegmiller syndrome or liver disorders
You must also provide information on all your ongoing medications

Q: When and how to consume the medicine?

Do not alter the dose unless advised. Do not stop the medicine abruptly. This can have adverse effects
Oral medication is supposed to be taken on an empty stomach, an hour before or two hours after meals
Swallow the capsule/ tablet as a whole. Do not break, chew or crush it
Shake the liquid medicine well before consuming it. Consume the exact prescribed quantity using a measuring spoon, dose syringe or medicinal cup
Mycophenolate Mofetil and Mycophenolic Acid are not absorbed equally. Hence, it is essential that you are careful about the prescribed brand and not mix one for the other

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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