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Molecule Description

Metolazone is a Thiazide-like Diuretic (water pill) which is primarily used to

treat congestive heart failure and high blood pressure.


Uses of Metolazone

  • Treatment of high blood pressure (hypertension)
  • Reduce swelling or fluid retention (edema) which can result from conditions such as congestive heart failure or kidney disease
  • Lowering high blood pressure helps prevent kidney problems, stroke, heart attacks

Contraindications of Metolazone

When should one not use Metolazone

  • Anuria (not passing urine)
  • Hepatic coma or pre-coma
  • Known allergy to this medicine or sulfonamides

Side effects of Metolazone

Common side effects of this drug are:

  • Dizziness
  • Lightheadedness
  • Drowsiness
  • Headache
  • Blurred vision
  • Loss of appetite
  • Diarrhea or constipation
  • Depression
  • Orthostatic hypotension (decrease in blood pressure)
  • Hypokalemia (decreased potassium levels)
  • Hypomagnesaemia (decreased magnesium levels)
  • Hyponatremia (decreased Sodium levels)
  • Hypophosphatemia (decreased phosphate levels)
  • Hyperglycemia (increased blood sugar levels)
  • Hypercalcemia (increased calcium levels)

Precautions and Warnings of Metolazone



Can I take Metolazone during pregnancy?
Taking this medicine during pregnancy is not safe as it appears in cord blood and crosses the placenta; it is not recommended in pre-eclampsia and other pregnancy-induced hypertension.

Breast Feeding

Can I take Metolazone while breastfeeding?
This medicine passes into breast milk; it is not safe to use during breastfeeding.


Can I drive if I have consumed Metolazone?
This medicine can cause dizziness or blurred vision. Do not drive until you feel well.


Can I consume alcohol with Metolazone?
  • This medicine has interactions with alcohol
  • Consuming alcohol may drastically reduce blood pressure

Other General Warnings

Talk to your doctor if
Reduce potassium levels in your blood. Consult your doctor for adding potassium to your diet.

Mode of Action of Metolazone

How Does It Work?

The actions of this medicine result from blocking the reabsorption of sodium ions in distal tubules of kidneys at the time of formation of urine; this can cause an increase in the excretion of water a...
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Interactions of Metolazone

Interactions with other medicines

This medicine interacts with numerous medicines. Do not take this medicine without doctor’s advice.

Interactions with food items

No food interaction found yet.

Dosage of Metolazone


Overdose symptoms may include fainting, severe weakness, a severe decrease in the amount of urine, slow or shallow breathing, etc. Seek emergency medical attention immediately if you think you have us...
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Missed a Dose

Take your missed dose as early as you possible. Skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

A: You should not use this medicine if you are allergic to it or any other Diuretic medicine. Give a detailed account of all your medical and surgical history and show all your previous and recent blood reports to your doctor. Also, tell your doctor about all the ongoing medicines, herbal medicines or nutritional supplements that you may be taking, before starting on this medicine.

Q: How to store this medicine?

A: Store this medicine at room temperature and away from moisture and sunlight. Keep out of reach of children.

Q: When and how to consume medicine?

A: Metolazone can be taken with or without food. Take this medicine at or around the same time every day. Follow the directions on your prescription label carefully and instructions given by your doctor.

Q: Can this medicine be given in children?

A: Safety and efficacy in children under 12 years has not been established, hence avoided in children.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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