Methylergometrine
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Molecule Summary
| Uses | Uterine bleeding in the second stage of labour |
| Therapy | Haemostatics |
| Side Effects | Abdominal pain, nausea, vomiting |
Medicines
available
19k pincodes
Molecule Description
Methylergometrine is used to control heavy bleeding from the uterus during childbirth, especially after the baby's shoulder is delivered. It works by helping your uterus tighten and contract strongly, which in turn squeezes the blood vessels and helps stop the bleeding. It also slightly narrows blood vessels, reducing blood loss and preventing heavy bleeding.
You should not take this medicine if you are allergic to it, have high blood pressure, have blood poisoning (toxaemia), or are pregnant. Common side effects may include high blood pressure, headache, seizures, stomach pain from uterine contractions, nausea, and vomiting. Your doctor or nurse will give you this medicine at the hospital, so you don't need to inject it yourself.
This medicine can interact dangerously with some antibiotics, HIV medications, antifungal drugs, and other medicines that affect blood vessels or the heart. It's essential to inform your doctor about all medications you are taking. If you have liver, kidney, or heart problems, or risk factors like smoking or diabetes, be extra careful when using this medicine. Also, keep it away from newborn medicines to avoid accidental mix-ups.
You should not breastfeed while using this medicine and for at least 12 hours after your last dose. Any breast milk collected during this time should be discarded. The medicine should be stored below 25°C, away from sunlight, children, and pets. Because the medicine is administered by a healthcare professional, missing a dose is unlikely. However, if you suspect a dose was missed, please notify your doctor or nurse immediately.
Uses
Methylergometrine is used to control uterine bleeding in the second stage of labour following delivery of the anterior shoulder.
Contraindications
When should one not use Methylergometrine
- If you are allergic to methylergometrine or any other ingredients of this medicine.
- If you have hypertension.
- If you have toxaemia ( blood poisoning ).
- If you are pregnant.
Side effects
Common side effects of this drug are:
- The most common side effect is hypertension associated in several cases with seizure and/or headache.
- Abdominal pain (caused by uterine contractions)
- Nausea
- Vomiting
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have liver or kidney problems, be extra cautious with Methylergometrine, as your body may not handle the drug well.
- You are breastfeeding; do not breastfeed while taking Methylergometrine. Pumped milk during treatment should be thrown away, and you should wait at least 12 hours after your last dose before breastfeeding again.
- You have heart disease or risk factors like smoking, diabetes, obesity, or high cholesterol, you may have a higher risk of heart problems from Methylergometrine.
- You store Methylergometrine at home or in a clinical setting, keep it far away from medications meant for newborns, since giving it to a baby by mistake can be extremely dangerous.
Mode of Action
How Does It Work?
Methylergometrine works by helping your uterus tighten and contract strongly after childbirth. These contractions help stop bleeding by squeezing the blood vessels in the uterus. It also constricts blood vessels slightly, which helps reduce blood loss and prevent heavy bleeding.
Interactions
Interactions with other medicines
- Avoid taking Methylergometrine with strong antibiotics (such as erythromycin or clarithromycin), HIV medications (like ritonavir or indinavir), or antifungals (like ketoconazole or itraconazole), as these can dangerously increase Methylergometrine's effects and lead to serious complications, including narrowed blood vessels or poor blood flow.
- Use caution when taking medications that moderately interact with Methylergometrine, such as fluconazole, fluoxetine, clotrimazole, and grapefruit juice, as they may still increase the risk of side effects.
- Some drugs, like nevirapine or rifampicin, may reduce how well Methylergometrine works by speeding up how it is broken down in the body.
- Using beta-blockers with Methylergometrine may increase the risk of high blood pressure or narrowing of blood vessels.
- Certain anaesthetics can make Methylergometrine less effective in helping the uterus contract during surgery.
- Methylergometrine may interfere with heart medications like glyceryl trinitrate, reducing their ability to relieve chest pain.
- Combining Methylergometrine with other drugs that constrict blood vessels (such as other ergot drugs or prostaglandins) can increase the chance of harmful side effects.
Dosage
Overdose
Methylergometrine will be given to you by a doctor or nurse. Therefore, it is less likely that you may get an overdose of the medicine. If you experience symptoms right after taking the medicine, seek medical help.
Missed a Dose
You will be monitored by the doctor or nurse as to when Methylergometrine should be given to you. Thus, it is unlikely that a dose of the medicine will be missed. If the doctor or nurse might have missed a dose, inform them.
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