Megestrol

Uses	Breast cancer, Loss of appetite
Therapy	Anti-Neoplastic, Drugs For Aids Associated Anorexia
Side Effects	Allergic reactions like swelling of the face, skin rash, difficulty breathing, Decreased sexual desire, Flatulence, Difficulty falling or staying asleep, Unexpected vaginal bleeding, Impotence

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Molecule Description

Megestrol (megestrol acetate) belongs to a group of medicines called progestogens and is used to treat certain types of hormone-dependent cancer, which include cancer of the breast. It can reduce the uneasiness caused due to the advanced stage of endometrial and breast cancer. It may also be used to treat certain symptoms of AIDS.

Uses

Hormone-dependent cancers such as breast cancer
Loss of appetite
Severe weight loss

Contraindications

When should one not use Megestrol

Allergy to megestrol acetate or any other ingredients of Megestrol
Thrombophlebitis (blood clots)

Side effects

Common side effects of this drug are:

Allergic reactions like swelling of the face, skin rash, difficulty breathing
Decreased sexual desire
Flatulence
Difficulty falling or staying asleep
Unexpected vaginal bleeding
Impotence

Precautions and Warnings

Pregnancy

Megestrol is not recommended during pregnancy.

Breast Feeding

Megestrol is not recommended while breastfeeding.

Driving

Megestrol does not have any effect on driving abilities. However, please watch how the medicine affects you before driving or operating heavy machinery.

Alcohol

Consumption of alcohol may worsen the side effects of Megestrol. Please tell your doctor if you have a habit of drinking alcohol before starting the medication.

Other General Warnings

Talk to your doctor if

You have allergies to megestrol acetate or any other ingredients of Megestrol
You have or have ever had blood clots, liver or kidney problems
You are going to have surgery, including dental surgery
You are over 65 years
You have a history of stroke
You have diabetes

Mode of Action

How Does It Work?

Megestrol acetate belongs to the progestin group of medications. Antitumour activity of megestrol acetate involves suppressing luteinising hormone and oestrogen release from the anterior pituitary gland. This anti-gonadotropic activity helps against cancer cells.

Interactions

Interactions with other medicines

Concomitant use of Megestrol acetate with warfarin increases the chances of adverse effects of the medicine
Concomitant use of dofetilide with megestrol will increase blood levels of dofetilide, which is harmful to the function of the heart
Concomitant use of megestrol with immunosuppressive medicine like filgotinib will increase the chances of microbial infections

Dosage

Overdose

Please go to the emergency department closest to you in case of overdose. In addition, please carry the product package with you to provide the doctor treating you with the necessary details.

Missed a Dose

If you miss a dose, please take it as soon as you realise it. Then, please skip the missed dose and take the next one if it is time for your next dose. Do not take two doses at a time.

Frequently Asked Questions (FAQs)

Megestrol can cause irregularities in the menstrual cycle in women. Please let your doctor know if you are trying to get pregnant.

Megestrol is not recommended for use in children.

Please continue to eat a well-balanced, healthy diet unless your doctor recommends a specific diet.

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