Irbesartan
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Molecule Description
Irbesartan belongs to the group of medicines known as angiotensin receptor blockers. It is at times given along with blood pressure medicines or other class for enhanced effect.
Uses
- It is used to treat high blood pressure
- It is also used to protect the kidney from high blood pressure and associated conditions like Type 2 diabetes
Contraindications
When should one not use Irbesartan
- If you have an allergy to Irbesartan or any ingredients of the medicine
- If you are more than three months pregnant
- If you have diabetes or having a kidney problem
Side effects
Common side effects of this drug are:
- Increased potassium levels in the blood – irregular heartbeats, chest pain, weakness, tingling
- Feeling dizzy, sickness (nausea), vomiting, raised heart muscle enzymes (like creatine kinase)
- Dizziness while getting up from a sitting or lying position (orthostatic hypotension), muscle and joint pains and low hemoglobin are common in patients with high blood pressure and Type 2 diabetes
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have excessive vomiting or loose motions
- You have kidney or heart problems
- You are suffering from diabetic kidney disease
- You are going to have any surgery
- You are taking any of the medicines used to treat high blood pressure and diabetes-related kidney problems (like Enalapril, Lisinopril, Ramipril, Aliskiren)
Mode of Action
How Does It Work?
Angiotensin II is a hormone which narrows the blood vessels in kidneys, heart and lungs and increases the blood pressure. It also raises the levels of a substance called aldosterone, which acts on kidneys to increase salt and fluid levels in the body and further increases blood pressure. Irbesartan blocks the effects of this angiotensin II and thus has a dual effect of relieving blood pressure by relaxing the blood vessels and protecting the kidney.
Interactions
Interactions with other medicines
- ACE-inhibitor or Aliskiren
- Potassium supplements and salt substitutes containing potassium
- Diuretics
- Medicines containing lithium
Interactions with food items
Irbesartan can be taken before or after meals.
Dietary Restrictions
Avoid potassium supplements or salt substitutes unless advised by your physician. Some high potassium fruits and vegetables should be avoided.
Dosage
Overdose
Accidental or unintentional overdose with Irbesartan may not be harmful. But if you experience symptoms such as low blood pressure (dizziness, feeling light-headed or fainting), fast or slow heart rate, consult your doctor.
Missed a Dose
Take the missed dose as early as you remember. If the next dose is too near, continue with your next scheduled dose and skip the missed dose. Do not take a higher or a double dose to compensate for it. Ideally, there should be a 12-hour gap between 2 doses.
Frequently Asked Questions (FAQs)
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