Hydroquinone+Mometasone Furoate+Tretinoin
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Molecule Summary
| Uses | Melasma |
| Therapy | Drugs For Melasma |
| Side Effects | Itching, redness, burning, irritation, thinning of the skin |
Assurance
available
Regulated
Molecule Description
Hydroquinone+Mometasone Furoate+Tretinoin is a prescription medication used to treat melasma, a skin condition that causes brown or dark patches on the face. It works by combining three active ingredients: hydroquinone, which helps lighten dark spots; mometasone, which reduces inflammation; and tretinoin, which promotes skin cell turnover for a smoother complexion. This medicine should be applied exactly as prescribed by your doctor, usually in a thin layer on affected areas. Avoid contact with your eyes, mouth, and genital areas, and always wash your hands after application. Using it more frequently than prescribed does not speed up results and may increase the risk of side effects. Common side effects may include skin irritation, redness, burning, or dryness. These effects usually subside with time, but if they worsen or persist, consult your doctor immediately. People with sensitive skin or underlying skin conditions should inform their doctor before starting this medicine. Always use sunscreen and protective clothing while using Hydroquinone+Mometasone Furoate+Tretinoin, as sun exposure can worsen melasma and reduce the effectiveness of the treatment. Avoid applying the medicine immediately before sun exposure or tanning, and do not use it on broken or infected skin. In case the medicine accidentally comes into contact with the eyes, rinse the eyes thoroughly with water and seek medical advice if irritation continues.
Uses
Hydroquinone+Mometasone Furoate+Tretinoin is used to treat moderate-to-severe melasma (dark and discoloured patches on the skin). It is used to lighten the skin tone or appearance, especially when there is dark pigmentation.
Contraindications
When should one not use Hydroquinone+Mometasone Furoate+Tretinoin
- If you are allergic to mometasone, tretinoin, hydroquinone or any of the ingredients of Hydroquinone+Mometasone Furoate+Tretinoin.
- If you have skin conditions such as eczema (infected skin due to allergy), rosacea (small red pustules on face), rashes around the mouth (perioral dermatitis) or damaged skin anywhere in the body.
- If you have a viral or fungal infection of the skin, any ulcers on the skin or tuberculosis.
- If you need to be exposed to the sun for prolonged periods (using sunscreen lotion is advisable).
- If you have a skin tumour or a family history of skin tumour.
Side effects
Common side effects of this drug are:
- Itching, redness, burning, irritation, thinning of the skin.
- Skin sensitivity at the site of application.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a history of allergic reactions after the application of topical creams.
- You are pregnant or are breastfeeding.
- You think rashes or infections have developed on the skin after using this medicine.
- Avoid contact with the eyes, mouth or nose. If it occurs wipe or wash it off immediately.
- You should avoid being exposed to direct sunlight, after applying this medicine, to reduce the chances of photosensitization (which means skin damage due to UV or sunlight). Try to use good sunscreen with at least SPF 15 and full clothes to avoid exposure.
Mode of Action
How Does It Work?
- Hydroquinone inhibits an enzyme known as tyrosinase, which is responsible for the production of a pigment called melanin. Melanin is responsible for skin pigmentation and melasma.
- Tretinoin is a metabolite of vitamin A and is keratolytic. It is responsible for the elimination of melanin that has been formed. It also has anti-inflammatory properties.
- Mometasone is a corticosteroid and it works by blocking the production of inflammatory chemicals like prostaglandins and leukotrienes. Mometasone narrows and constricts blood vessels, which are dilated (widened) and leaky and allowing other inflammatory cells into the skin to promote the inflammatory response.
Interactions
Interactions with other medicines
- Since this medicine is to be used externally on the skin, it is less likely to interact with other medicines. However, always consult your doctor if you are taking other medicines for treating other health conditions.
- You should always tell the doctor if you are taking any other medicines, herbal preparation or supplements to avoid any interaction with Hydroquinone+Mometasone Furoate+Tretinoin.
Interactions with food items
Hydroquinone+Mometasone Furoate+Tretinoin is for external use only.
Dosage
Overdose
As this medicine is meant for external application, cases of an overdose are unlikely. However, upon accidental ingestion, contact your doctor immediately or visit the nearest hospital. If you have overapplied it, then wipe out the excess medicine with tissue or cotton. Excessive use for a prolonged duration is not advisable as it can lead to hormonal issues.
Missed a Dose
If you have missed the application of this medicine, then apply it as soon as possible. Do not overapply this medicine to compensate for the missed application.
Frequently Asked Questions (FAQs)
Articles
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References:
- Tretinoin Topical: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2022 [cited 15 June 2026]
- Mometasone Topical: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2022 [cited 15 June 2026]
- Schwartz C, Jan A, Zito PM. Hydroquinone. [Updated 2023 Aug 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan- [Accessed 15 Jun 2026].
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 441336, Mometasone Furoate. Retrieved December 26, 2024
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