Glyceryl Trinitrate

Uses	angina pectoris
Therapy	Anti-Anginal
Side Effects	nausea, vomiting, dizziness, vertigo, throbbing headache, fluctuations in heart rate

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Molecule Description

Glyceryl Trinitrate is a vasodilator used in heart diseases. It is used to treat angina pectoris, a chest pain caused by reduced blood flow to the heart. Glyceryl Trinitrate works by relaxing the blood vessels, thereby lowering the load on the heart. The dose and duration of this medicine varies among individuals depending on the severity of the condition. Do not take more than the prescribed dose in 24 hours. Do not stop the medication on your own without consulting the doctor.

Uses

Relief of Angina pectoris

Contraindications

When should one not use Glyceryl Trinitrate

Allergy to Glyceryl Trinitrate or any other excipient
Patients taking sildenafil, vardenafil, tadalafil
Patients with increased pressure in the brain due to trauma
Anaemia
Closed-angle glaucoma (Increased pressure in the eye)
Chest pain due to abnormal thickening of the heart muscle (hypertrophic obstructive cardiomyopathy)

Side effects

Common side effects of this drug are:

Throbbing headaches
Vertigo
Dizziness
Drowsiness
Increased/Decreased heart rate
Raised/Decreased blood pressure
Weakness
Fainting
Flushing of face
Nausea
Vomiting
Allergic skin reactions
Heartburn
Impaired breathing
Palpitations

Precautions and Warnings

Pregnancy

Glyceryl Trinitrate should be avoided during pregnancy unless recommended by the physician.

Breast Feeding

It is unknown whether Glyceryl Trinitrate is excreted in breast milk. Therefore, the risk to the infant remains unknown. Hence, Glyceryl Trinitrate should be avoided during breastfeeding unless recommended by the physician.

Driving

Glyceryl Trinitrate may cause dizziness and drowsiness. Hence caution is advised before driving or operating machines.

Alcohol

Alcohol may intensify the dizziness and drowsiness caused by this medicine. Therefore, caution is advised.

Other General Warnings

Talk to your doctor if

You are allergic to Glyceryl Trinitrate or any other excipient
You have liver or kidney disorder
You have a heart disease
You have low blood pressure
You are on heparin therapy
You have severe breathing difficulties
You are taking other medication for the similar condition
You are taking herbal, nutritional supplements, vitamins or minerals

Mode of Action

How Does It Work?

Glyceryl Trinitrate acts on blood vessels and smooth muscles, leading to their dilatation which relieves the pain.

Interactions

Interactions with other medicines

Glyceryl Trinitrate along with vasodilators, antihypertensives, beta-blockers, calcium channel blockers and neuroleptics, tricyclic antidepressants and sapropterin, can lead to low blood pressure
N-acetylcysteine may increase the effects of Glyceryl Trinitrate
Glyceryl Trinitrate may interfere in the clotting mechanism when used with heparin
Glyceryl Trinitrate and anticholinergic, antimuscarinics, tricyclic antidepressants can cause dryness of mouth
Ergot alkaloids may oppose the vasodilatation effect of Glyceryl Trinitrate
Sildenafil, vardenafil and tadalafil should not be taken with Glyceryl Trinitrate as they can cause a severe fall in blood pressure

Dosage

Overdose

In case of overdose, you may experience dizziness, nausea, or lightheadedness. If you experience these symptoms, visit the nearest hospital or contact your doctor immediately.

Missed a Dose

If you forget to take a dose, take it as soon as you remember. If the next dose is approaching, skip the missing dose. Use your next dose at the same time every day. To catch up, do not increase the dose.

Frequently Asked Questions (FAQs)

While travelling do not keep the medicine close to your body. Keep it in a purse, wallet or a handbag.

It is best to discuss with your physician about any possible drug interactions of Glyceryl Trinitrate and herbal medicines before using both together.

No habit forming tendencies have been reported with Glyceryl Trinitrate.

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Glyceryl Trinitrate

Molecule Summary