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Glimepiride+Voglibose+Metformin

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Molecule Summary

Uses
Type 2 diabetes
Therapy
Anti-Diabetic
Side Effects
Low blood sugar, loss of appetite, headache
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Molecule Description

Glimepiride+Voglibose+Metformin is an anti-diabetic medicine used to manage type 2 diabetes mellitus. It is a combination of metformin, glimepiride and voglibose as active ingredients. Do not miss any dose or abruptly stop taking this medicine without informing your doctor. Patients are advised to maintain a strict exercise and diet regimen in conjunction with this medicine to achieve the best possible effect. To prevent low blood glucose levels, it's essential to have regular meals, carry a fast-acting source of glucose, and limit alcohol consumption. It is also advisable to always carry candy or chocolate with them when going out, in case they suddenly experience symptoms of low blood sugar levels, such as dizziness, irritability, hunger pangs, and sweating. The most common side effects of Glimepiride+Voglibose+Metformin include low blood glucose levels (hypoglycaemia), taste changes, nausea, diarrhoea, stomach pain, headache, oedema (swelling), blurred vision, bone fracture, and upper respiratory tract infection. Some people may also experience weight gain. Avoid taking this medication if you have type 1 diabetes mellitus, diabetic ketoacidosis (high levels of acid in your blood), or severe kidney or liver disease. Inform your doctor before taking this medicine if you have a history of heart disease, as it may not be suitable for you. Pregnant or breastfeeding women should consult their doctor before taking it. Regularly check your blood sugar levels, and your doctor may recommend blood tests to monitor your blood cell counts and liver function.

Uses

Glimepiride+Voglibose+Metformin is used to treat type 2 diabetes mellitus when diet, exercise and single anti-diabetic medicines are not able to control the blood sugar levels adequately.

Contraindications

When should one not use Glimepiride+Voglibose+Metformin

  • If you are allergic to this medicine or any of the ingredients of Glimepiride+Voglibose+Metformin.
  • If you are pregnant or breastfeeding.
  • If you have severe kidney or liver problems.
  • If you have any metabolic acidosis (too much acid in the body fluids), such as lactic acidosis, diabetic ketoacidosis or diabetic pre-coma.
  • If you have shock or acute heart failure.
  • If you are an alcoholic.
  • If you have a history of severe infection pre- or post-surgery.
  • If you have a stomach or intestinal obstruction.

Side effects

Common side effects of this drug are:

  • Low blood sugar levels
  • Nausea, vomiting, diarrhoea, loss of appetite, and stomach ache are common symptoms that appear at the beginning of treatment and settle gradually.
  • Altered taste
  • Bloating
  • Flatulence

Precautions and Warnings

Pregnancy

Pregnancy

You should not take this medicine during pregnancy. Your doctor may advise you to switch over to insulin.

Breast Feeding

Breast Feeding

It is not safe to breastfeed during the treatment. It can harm the newborn baby. The doctor may either switch over to insulin or may ask you to stop breastfeeding.

Driving

Driving

You may experience decreased or increased blood sugar which may alter your mental alertness and visual disturbance. Keep a juice or chocolate in the car close to you when driving, in case you start feeling any of the symptoms of hypoglycaemia like dizziness, irritability, hunger pangs, or sweating, immediately have the juice or chocolate.

Alcohol

Alcohol

It is unsafe to consume alcohol with this medicine. Consumption of alcohol, together with this medicine, may affect blood glucose levels in patients with diabetes.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have been advised to do a CT scan or MRI with contrast media, then inform the hospital that you are on Glimepiride+Voglibose+Metformin. Your doctor will advise you to stop the medicine a few days before the investigation.
  • You experience diarrhoea, vomiting, dehydration or less fluid intake.
  • Prolonged fasting should be avoided. Never miss your meals.
  • You are taking other medicines for diabetes, caution is needed, as a fall in blood glucose can occur.
  • You are taking any antihypertensive medicines, painkillers or water pills.
  • You have an upcoming surgery, the doctor may adjust the dose or replace the medicine for a few days.
  • You have pre-existing medical conditions such as intestinal diseases like Roemheld syndrome (epigastric pressure in the gastrointestinal tract), severe hernia, obstruction or ulcers in the intestine, etc.
  • You have a kidney or liver disorder, thyroid disorder, or G6PD deficiency.
  • Monitoring of vitamin B12 is recommended if you are on long-term treatment with Glimepiride+Voglibose+Metformin.

Mode of Action

How Does It Work?

This combination better controls blood sugar than metformin, voglibose, or glimepiride alone. Insulin moves glucose from the blood into the cells. Glimepiride increases insulin release, while metformin reduces glucose absorption, lowers sugar production by the liver, and facilitates sugar entry into cells. Voglibose delays carbohydrate absorption in the intestines, preventing spikes in blood glucose levels after meals.

Interactions

Interactions with other medicines

  • Glimepiride+Voglibose+Metformin may interact with other medicines if taken at the same time. Always inform your doctor about all the medicines you are taking, including all prescribed or non-prescribed herbal medicines, dietary supplements as well and other treatments you are taking for any disorder.
  • In particular, if you are taking medicines for brain and heart-related disorders, tuberculosis, acidity, fungal infections, painkillers, antihypertensive medicines, etc.
  • You may have symptoms of high blood sugar if you are taking oral contraceptives, water pills, rifampicin (anti-tuberculosis medicine), medicines for constipation, phenytoin (anti-epileptic medicine), and medicines for thyroid disorders.
  • Glimepiride+Voglibose+Metformin may alter the way blood thinners work like phenprocoumon.
  • Other medicines, like oral contraceptives, other anti-diabetics, etc, can affect blood glucose levels. Therefore, concomitant use should be undertaken with caution.

Dosage

Overdose

An overdose of this medicine may cause hypoglycaemia (excessively low blood sugar) and may present with extreme weakness, confusion, tremors, fast heart rate, nausea, and rapid breathing. You must immediately take sugar, if possible in the form of glucose. Seek emergency medical attention if you think you have used too much of this medicine.

Missed a Dose

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed one and stick to your regular dosing schedule. Do not take a double dose to make up for the missed one, as this can be harmful and lead to a drop in glucose levels.

Frequently Asked Questions (FAQs)

Glimepiride+Voglibose+Metformin is a medication that helps regulate high blood glucose (sugar) levels. Glimepiride increases insulin release, metformin lowers sugar production by the liver and facilitates sugar entry into cells, and voglibose slows the digestion and absorption of carbohydrates in the intestine, reducing the rise in blood glucose levels after meals.

Glimepiride+Voglibose+Metformin is used for the management of type 2 diabetes mellitus when diet, exercise and single anti-diabetic medicines are not able to control the blood sugar levels adequately.

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