Gliclazide+Metformin Hydrochloride+Pioglitazone

Uses	Type 2 diabetes
Therapy	Anti-Diabetic
Side Effects	Nausea, vomiting, diarrhoea, stomach pain, decreased blood sugar levels

100% Authentic
Medicines

Cash on delivery
available

Delivery across
19k pincodes

Molecule Description

Gliclazide+Metformin Hydrochloride+Pioglitazone is a combination medicine containing gliclazide, pioglitazone and metformin. They belong to the anti-diabetic class of medicines. It is used to treat type 2 diabetes and works by lowering blood sugar levels. It is used when diet, exercise and single agents and second-line therapy with two medicines fail to achieve the desired blood sugar level. This medicine should not be used in children below 18 years of age. Inform your doctor about all the medical conditions you have or had. Take this medicine regularly at the same time to get optimal benefits. Your doctor will decide the best-suited dose for you and this may change from time to time depending on how it is working to control your blood sugar levels.

Uses

Gliclazide+Metformin Hydrochloride+Pioglitazone is used in the treatment of type II diabetes mellitus when diet, exercise and single agents and second-line therapy with two medicines do not result in an adequate glycemic control in adults.

Contraindications

When should one not use Gliclazide+Metformin Hydrochloride+Pioglitazone

If you are allergic to Gliclazide, Metformin, Pioglitazone or any other components of Gliclazide+Metformin Hydrochloride+Pioglitazone.
If you have Type 1 diabetes.
If you have or had a history of cardiac failure.
If you have complications such as diabetic ketoacidosis, lactic acidosis, diabetic pre-coma and coma.
If you have severe liver or kidney disorders.
If you have or had a history of bladder cancer.
If you are breastfeeding.
If you are on treatment with miconazole.
If you have blood in the urine that your doctor has not checked.

Side effects

Common side effects of this drug are:

Nausea, vomiting, diarrhoea, stomach pain and loss of appetite
Sore throat, the common cold
Decreased blood sugar levels
Altered sense of touch and taste
Joint pain, fracture, weight gain

Precautions and Warnings

Pregnancy

There is limited information about the effects of this medicine during human pregnancy. However, your doctor may give you this medicine only if it is needed. Consult your doctor before taking any medicines during pregnancy.

Breast Feeding

There is limited information about the effects of this medicine in breastfeeding women. However, your doctor may give you this medicine only if it is needed. Consult your doctor before taking any medicines during breastfeeding.

Driving

If you experience any of the side effects of this medicine like visual disturbances, dizziness, lower sugar level than normal then avoid driving.

Alcohol

You cannot consume alcohol while on this medicine. However, if you have a habit of consuming it daily talk to your doctor.

Other General Warnings

Talk to your doctor if

You have heart failure problems or retain water (fluid retention) and your age is more than 75 years.
You have a special type of diabetic eye disease called macular oedema (swelling of the back of the eye).
You have cysts on your ovaries (polycystic ovary syndrome). There may be an increased possibility of becoming pregnant because you may ovulate again when you take this medicine.
You have a liver and kidney problem.
Your blood sugar falls below the normal level (hypoglycaemia).
You experience a reduction in blood count (anaemia).
You have weaker bone strength, particularly in women.
You experience vomiting, stomach ache, a rapid increase in weight or localised swelling (oedema), muscle cramps, difficulty in breathing, reduced body temperature and heartbeats.
You have Type 1 diabetes and you consume alcohol.
You have a planned surgery.
Gliclazide+Metformin Hydrochloride+Pioglitazone is not recommended to be used by children below 18 years of age.

Mode of Action

How Does It Work?

Metformin works by reducing the glucose production in the liver, increases insulin (that is used to regulate the level of glucose in the body) sensitivity thereby improves glucose uptake and utilisation and delays glucose absorption in the intestine.
Gliclazide acts on the pancreas and increases the secretion of insulin which further lowers the blood sugar level.
Pioglitazone works by improving or making cells more sensitive to insulin (or reducing insulin resistance) and makes it easier for sugar (glucose) in the blood to get into the cells.

Interactions

Interactions with other medicines

As this medicine contains Gliclazide, Pioglitazone and Metformin any interaction seen with them when taken alone may happen with this combination too.
Concomitant use of phenylbutazone with Gliclazide+Metformin Hydrochloride+Pioglitazone increases the effect of lowering blood sugar levels, thereby can cause an incidence of lower than normal blood sugar level.
Concomitant use of danazol, chlorpromazine, glucocorticoids with this medicine increases the blood sugar level.
Concomitant use of verapamil decreases the effect of Gliclazide+Metformin Hydrochloride+Pioglitazone.
Concomitant use of gemfibrozil increases the effect of this medicine.
Concomitant use of this medicine with warfarin increases the effect of warfarin.
Concomitant use of alcohol with this medicine decreases blood sugar level and can lead to a change in the body's acid-base balance.
Fluoroquinolones along with this medicine can lead to a risk of an imbalance in blood sugar levels.
Discuss with your doctor about any other medicines, herbal preparations and supplements you are taking currently to avoid any possible drug interactions.

Dosage

Overdose

Excess of Gliclazide+Metformin Hydrochloride+Pioglitazone can cause decreased blood sugar level characterised by sweating, increased thirst, dizziness. It can also lead to disturbances in the body's acid-base balance and in rare circumstance coma and fits. If you experience any of the symptoms or think you have taken too much of this medicine, then contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you have missed any dose of Gliclazide+Metformin Hydrochloride+Pioglitazone, then take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

Living a healthy and active lifestyle is highly recommended which helps achieve control your blood sugar. Never skip meals, have meals every 2 -3 hours in a small proportion. Follow the diet provided to you properly. Include more fruits, vegetables, salad, nuts in your diet and fewer fats and carbohydrates. Exercise regularly and lose weight. Do not take any kind of stress.

You will experience the signs of low blood glucose levels such as sweating, dizziness, headache and increased heart rate. To prevent this episode, it's important to have meals at regular time intervals daily and always carry glucose-containing food such as sugary food, chocolate or fruit juice with you.