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Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen

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Molecule Summary

Uses
Migraine
Therapy
Migraine Drugs
Side Effects
Cold hands and feet, irregular heartbeat, blood pressure fluctuation, numbness, nausea, dizziness, muscle pain, itching, swelling
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Molecule Description

Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen is an anti-migraine medicine that is used in the treatment and prevention of migraines. Migraine is a type of headache associated with symptoms like severe headaches, nausea and sickness, and visual disturbances, sensitivity to light etc. It provides symptomatic relief in migraine-associated symptoms. It contains a combination of caffeine, ergotamine, paracetamol and prochlorperazine as its active ingredients. It is advised to take Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen at the prescribed dose and duration as advised by your treating doctor. Along with the medication you should also try to avoid migraine triggering factors such as stress, poor sleeping patterns, direct sunlight, tiredness, certain medications like sleeping pills, etc.

Uses

Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen is used for the treatment and prevention of migraine attacks along with associated symptoms such as nausea, vomiting, visual disturbance, etc.

Contraindications

When should one not use Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen

  • If you are allergic to caffeine, ergotamine, paracetamol and prochlorperazine or any of the ingredients of Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen.
  • If you are already taking any other medicine containing any of the active ingredients present in Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen.
  • If your age is below 16 years.
  • If you are pregnant or breastfeeding.
  • If you have any pre-existing medical condition such as liver or kidney problem, any kind of heart disorder, swelling in blood vessels etc.
  • If you are already on certain medications antibiotics, anti-HIV medicine, anti-fungal medicines, heart and blood pressure-related medicines, oral contraceptives and other medicines like ergotamine, sumatriptan, fluvoxamine, nicotine, etc.
  • If you have a history of fibrosis (thickening of the tissue) due to treatment with ergotamine.

Side effects

Common side effects of this drug are:

  • Cold hands and feet
  • Irregular heart beat
  • Blood pressure fluctuation
  • Numbness
  • Nausea
  • Dizziness
  • Muscle pain
  • Itching
  • Swelling

Precautions and Warnings

Pregnancy

Pregnancy

Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen is not recommended to be used during pregnancy, as its components can cause harm to the placenta (connects with the foetus). Hence it is recommended not to use the same unless prescribed by your doctor. It is often advised that one should try to identify the potential migraine triggers and avoid them.

Breast Feeding

Breast Feeding

One of the components of this medicine passes into the breastmilk and can cause vomiting, diarrhoea, weak pulse and unstable blood pressure in a breastfed baby. Therefore, it is recommended to avoid taking this medicine. Talk to your doctor for more information.

Driving

Driving

This medicine may cause dizziness. So it is advised not to drive, unless you know how this medicine affects you.

Alcohol

Alcohol

It is advised not to consume alcohol while taking this medicine, as it may increase side effects like dizziness, drowsiness.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have any pre-existing medical conditions such as heart disorder, liver or kidney problem, thyroid, asthma, hypertension, stomach ulcers, increased pressure inside the eyes (glaucoma), muscle weakness, blood-related disorder, etc.
  • You are pregnant or breastfeeding.
  • You experience chest pain, tingling in fingers and toes, immediately stop the treatment.
  • You are already taking certain medications or any other medicine containing any of the active ingredients present in Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen, etc.
  • You experience sudden vision loss, headache or any kind of allergies like bumps and swelling in the skin, itching, breathlessness, dizziness, tingling in fingers, etc after taking this medicine.
  • You have a low level of potassium, calcium and magnesium.
  • You may experience chest tightness if used in excess dose for a prolonged duration.
  • You have or experience any clot (fibrosis).

Mode of Action

How Does It Work?

  • Sometimes headache pains are caused due to widened vessels in the head.
  • Ergotamine works by preventing blood vessels in the head from expanding and causing headaches.
  • Caffeine increases the absorption of ergotamine in the brain and also enhances the vasoconstrictive effect of ergotamine and thus, helps in narrowing the blood vessels in the brain.
  • Prochlorperazine acts as an anti-emetic that prevents nausea and vomiting associated with migraines by blocking the signals in the specific part of the brain that is responsible for nausea or vomiting.
  • Paracetamol works by interfering with the production of a chemical called prostaglandins, which is responsible for the sensation of pain.

Interactions

Interactions with other medicines

  • Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen may interact with other medications and provide an altered response to the treatment. Please notify your doctor if you are undergoing any other treatments, over-the-counter medications (that you buy without a prescription) and herbal preparations.
  • Especially if you are taking any painkiller, anti-diabetic medicine, antibiotics, antacids, antiallergic medicine, anti-epileptic medicines, brain or mood-related disorder, anti-parkinson's medicines, heart and blood related medicines etc.

Interactions with food items

  • You should avoid excessive intake of tea, coffee, chocolate or fizzy drinks containing caffeine.

Dosage

Overdose

  • If you think you have taken too much of Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen, and experience any unusual symptoms of drowsiness, irregular heartbeat, feeling cold, numbness in fingers or toes, muscle weakness, etc. contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you missed any dose of medicine take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

A migraine is a condition defined as throbbing pain or severe pain in the head or headache. It has many associated symptoms like nausea, vomiting, sensitivity to light and loud noise, visual disturbance, etc.

Exercise regularly. Get a good amount and quality of sleep. Do meditation and yoga, it helps in relieving stress and provides relaxation. Keep yourself well hydrated. Drink plenty of fluids. Try to avoid the factors that triggers your migraine.Do not take any kind of stress.

No, abruptly stopping the medicine can worsen the headache. So it is advised to follow the prescribed dose and duration. Your doctor will decide when to stop this or reduce the dose.

No, do not suggest this medicine to others with headache, as headache can be due to varied reasons. Thus, it is advised to always consult a doctor for appropriate diagnosis and treatment.

Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen is used for the treatment and prevention of migraine attacks along with associated symptoms such as nausea, vomiting, visual disturbance, etc.

No, this medicine should not be immediately stopped after relieving the symptoms. Gradual weaning of the medication should be done to avoid adverse effects. The doctor might switch to any other substitute medicine before stopping the treatment with Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen.

The doctor will decide the specific dose for a specific duration depending upon the severity of the condition. Do not take it endlessly on your own without consulting a doctor.

Ergotamine+Prochlorperazine+Caffeine+Paracetamol / Acetaminophen can be taken with or without food or as told by the doctor. But it is recommended to take the medicine at the same time every day for optimum results.

Nausea, vomiting, dizziness, fluctuation in blood pressure and irregular heartbeat are a few side effects that can be seen during the treatment. These can be serious. Seek medical help immediately if you notice chest pain, numbness or tingling in fingers and toes, or an irregular heartbeat. Not everyone experiences the same side effects.

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