Eplerenone

Molecule Description

Eplerenone is used to reduce the risk of complications or death due to heart fa

ilure (impaired pumping efficiency of the heart). It belongs to a class of medicines called ‘aldosterone blocking agents.’

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Eplerenone

It is used to treat and prevent heart failure.

Contraindications of Eplerenone

When should one not use Eplerenone

Allergy to Eplerenone or any components of the medicine
Medicines that increase potassium levels in the body (Spironolactone, Potassium supplements, etc.)
Severe kidney or liver disease
Medicines to treat infections (Clarithromycin, Telithromycin, Ketoconazole, Itraconazole, Nelfinavir, Ritonavir)
Nefazodone (treats depression)
If you are taking a certain class of blood pressure medications (ACE inhibitors - Ramipril, Lisinopril, Enalapril) with another particular type of medicines called angiotensin receptor blockers or ARB...
Read more

Side effects of Eplerenone

Common side effects of this drug are:

Elevated levels of potassium in the body (headache, nausea, muscle cramps or loose motions)
Feeling dizzy, fainting (low blood pressure)
High cholesterol levels
Difficulty in sleeping
Constipation
Weakness, muscle aches
Rashes, itching
Kidney problems (increased urea and creatinine levels)
Increase in certain types of white blood cells (eosinophilia), dehydration, infections, low sodium levels, gall bladder problems, blood clots in the leg, sore throat, increased sweating, male breasts,...
Read more
Severe allergic reactions causing swelling of face, lips, throat causing difficulty in breathing and swallowing, with or without itching, rashes, skin blisters and peeling

Precautions and Warnings of Eplerenone

Pregnancy

Can I take Eplerenone during pregnancy?

Eplerenone is not known to cause any harmful effects to the baby, but careful and close monitoring is recommended while using in pregnant women, due to lack of adequate data.

Breast Feeding

Can I take Eplerenone while breastfeeding?

It is not known if Eplerenone is secreted in breast milk. But, because this medicine is used in severe conditions that may harm the mother, a careful decision has to be taken by the doctor about discontinuing the medication or even breastfeeding.

Driving

Can I drive if I have consumed Eplerenone?

Eplerenone does not affect your ability to drive. But taking into account the condition of your heart and side effects such as dizziness, caution is advised.

Alcohol

Can I consume alcohol with Eplerenone?

Alcohol lowers blood pressure, causes drowsiness and is not suitable for your heart. Hence it is advised to avoid alcohol while taking Eplerenone.

Other General Warnings

Talk to your doctor if

You have kidney or liver diseases
You are taking:
Lithium (for extreme mood swings)
Cyclosporine or Tacrolimus (used to treat allergic skin reactions and suppress the immune system, especially after an organ transplant)

Mode of Action of Eplerenone

How Does It Work?

Aldosterone is a hormone secreted by adrenal gland present above the kidney. The primary function of this substance is to prevent excretion of water by the kidneys. Eplerenone blocks the action of ald...

Interactions of Eplerenone

Interactions with other medicines

Medicines to treat infections (Clarithromycin, Telithromycin, Ketoconazole, Itraconazole, Nelfinavir, Ritonavir)
Nefazodone (treats depression)
Do not take these two classes of blood pressure medications together while taking Eplerenone
ACE inhibitors (Ramipril, Lisinopril, Enalapril) with Angiotensin Receptor Blockers or ARBs (Losartan, Telmisartan, Valsartan, etc.)
Use with caution:
Medicines used to treat depression, mood disorders, psychosis (Lithium, Chlorpromazine, Haloperidol, Amitryptiline, Amoxapine)
Medicines used to suppress the immune system or immune response (Cyclosporine, Tacrolimus Hydrocortisone, Prednisone, Tetracosactide)
Medicines used to treat bacterial infections (Trimethoprim, Erythromycin, Rifampicin)
Amifostine (cancer treatment)
Baclofen (treats muscle tightness)
Digoxin and Amiodarone (used for irregular heart rhythms)
Certain blood pressure medications (Diltiazem, Verapamil)
Anti-seizure medications (Carbamazepine, Phenytoin, Phenobarbital)
Pain killers

Interactions with food items

Eplerenone can be taken with or without food.

Dietary Restrictions of Eplerenone

No information is available on dietary restrictions while you are taking this medicine, consult your doctor or pharmacist for further information.

Dosage of Eplerenone

Overdose

Be careful while using Eplerenone. It is strictly recommended to avoid any overdose. Symptoms of overdosage may include slow heart rate, weak pulse, muscle weakness, dizziness or feeling like you migh...

Missed a Dose

Take the missed dose as early as you remember. Ensure to have at least a 12-hour gap between two dosages. Skip the missed dose if your next dose is due in less than 12 hours and continue with the usua...

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: Is there anything else I should know before taking Eplerenone ?

Eplerenone is usually given in combination with other medications. It is started on a low dose
and then increased gradually.
Eplerenone can elevate blood potassium levels and regular blood tests are required to monitor
this. Checking for potassium levels is necessary in the first week and after the first month of
starting the treatment (before changing the dose). The correct dose needs to adjusted based on
the blood potassium levels.
Dose adjustment may be required in kidney disease.
Take this medicine with plenty of water.

Q: Is Eplerenone a safe medicine?

Eplerenone is associated with good control of blood pressure, reduced death rates due to
heart disease and improved survival rates.
It has a better safety profile than the other medicine in its class (spironolactone).
Eplerenone can increase blood potassium levels and cause irregular heartbeats or rhythms, but
these effects are not very severe.
This medicine is specifically used when there are increased levels of the hormone aldosterone
which causes decreased fluid excretion and increased levels in the body leading to high blood
pressure and load on the heart. Aldosterone also has harmful effects on the heart.
Eplerenone blocks aldosterone and its actions and will prove beneficial for survival.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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