Eperisone+Diclofenac

Uses	Spastic paralysis, periarthritis, low back pain
Therapy	Analgesic
Side Effects	Stomach pain, heartburn, indigestion, vertigo, spots or skin rash

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Molecule Description

Eperisone+Diclofenac is a combination medicine that is used to alleviate muscular spasm discomfort. It is a combination of eperisone and diclofenac. It helps muscles move more freely and relieves the pain and suffering associated with muscle spasms.

Uses

Spastic paralysis
Periarthritis
Low back pain

Contraindications

When should one not use Eperisone+Diclofenac

Hypersensitivity to any ingredient of this medicine
Active, gastric or intestinal ulcer, bleeding, or perforation
History of gastrointestinal bleeding or perforation, relating to previous non-steroidal anti-inflammatory agents therapy
Active, or history of recurrent peptic ulcer/haemorrhage
Stevens-Johnson syndrome
Hepatic or renal failure
Last trimester of pregnancy
Established congestive heart failure (NYHA-II-IV), ischemic heart disease, peripheral arterial disease, and/or cerebrovascular disease

Side effects

Common side effects of this drug are:

Stomach pain
Heartburn
Nausea or vomiting
Diarrhoea
Dyspepsia
Loss of appetite
Indigestion
Vertigo
Dizziness
Headache
Spots or skin rash
Raised blood liver enzymes
Changes in blood pressure

Precautions and Warnings

Pregnancy

This medicine should not be used during pregnancy because it poses a harm to the unborn child. However, in some life-threatening instances where the advantages outweigh the hazards, the doctor may prescribe it.

Breast Feeding

No, as the components of Eperisone+Diclofenac can pass into breast milk.

Driving

Eperisone+Diclofenac may induce negative effects that impair your driving ability, such as, headaches, blurred vision, dizziness, vertigo, fatigue, or drowsiness. This may impair your driving skills.

Alcohol

It is not recommended to drink alcohol while using Eperisone+Diclofenac.

Other General Warnings

Talk to your doctor if

You are suffering from liver or kidney disease
You are suffering from systemic lupus erythematosus
You have an active bleeding

Mode of Action

How Does It Work?

Eperisone is a muscle relaxant which operates on the brain and spinal cord's centres to ease muscle stiffness and spasms, as well as improve pain and muscle movement. Diclofenac is an nonsteroidal anti-inflammatory agent that acts by preventing the release of particular chemical messengers that induce pain and inflammation (redness and swelling).

Interactions

Interactions with other medicines

Eperisone+Diclofenac may raise lithium plasma concentrations
Eperisone+Diclofenac may cause digoxin plasma concentrations to rise
Concomitant treatment with potassium-sparing diuretics, ciclosporin, tacrolimus, or trimethoprim may result in elevated serum potassium levels, which should be checked on a regular basis
Concomitant treatment with anticoagulants and antiplatelet medicines may enhance the risk of bleeding
Eperisone+Diclofenac along with selective serotonin reuptake inhibitors may raise the risk of gastrointestinal bleeding
Eperisone+Diclofenac can reduce methotrexate clearance and so raise methotrexate levels
Eperisone+Diclofenac may aggravate ciclosporin nephrotoxicity
Eperisone+Diclofenac with tacrolimus may increase risk of nephrotoxicity
Quinolones and Eperisone+Diclofenac may interact resulting in convulsions
Eperisone+Diclofenac increases phenytoin plasma levels
Colestipol and cholestyramine can cause diclofenac absorption to be delayed or decreased
Cardiac glycosides with Eperisone+Diclofenac at the same time can worsen cardiac failure, lower GFR, and raise plasma glycoside levels
Eperisone+Diclofenac should be avoided for 8-12 days following mifepristone administration since they can impair mifepristone's action

Dosage

Overdose

Overdosing can result in headaches, nausea, vomiting, epigastric discomfort, gastrointestinal bleeding, diarrhoea, dizziness, disorientation, excitement, coma, sleepiness, tinnitus, fainting, or convulsions, among other symptoms. Acute renal failure and liver damage are probable side effects of serious poisoning. Visit your doctor immediately in case of an overdose.

Missed a Dose

Take this medicine as soon as possible if you miss a dose. However, if your next dose is approaching, skip the missing dose and return to your regular schedule. Do not take two doses.

Frequently Asked Questions (FAQs)

The safety and efficacy of Eperisone+Diclofenac are not established in children. Please seek medical advice from a physician before using it.

You may be able to stop once you feel better, but seek medical advice from your doctor before stopping the medicine.

There is a rare possibility that the medicine may cause impotence. Please consult your doctor for more information.

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