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Empagliflozin+Sitagliptin

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Molecule Summary

Uses
Type 2 diabetes mellitus
Therapy
Anti-Diabetic
Side Effects
Urinary tract infection, thirst, frequent urination, rash, low blood sugar and genital fungal infections
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Molecule Description

Empagliflozin+Sitagliptin is used to treat type 2 diabetes when blood sugar levels cannot be controlled with diet and exercise alone. It is a combination of empagliflozin and sitagliptin. Take this medicine as prescribed by your doctor, preferably after meals. Do not stop taking this medicine, as it can result in increased blood sugar levels and their complications. It is recommended to carry sugar candy along, as this medicine can cause a low blood glucose level as a side effect. If you frequently experience signs of low blood glucose levels, consult your doctor, as they may adjust the dose of this medication. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting Empagliflozin+Sitagliptin.

Uses

Empagliflozin+Sitagliptin is used to control high blood sugar in patients with type 2 Diabetes mellitus, along with a healthy diet and regular exercise.

Contraindications

When should one not use Empagliflozin+Sitagliptin

  • If you are allergic to Empagliflozin, Sitagliptin, or any other ingredients of Empagliflozin+Sitagliptin.
  • If you have severe kidney or liver disease.

Side effects

Common side effects of this drug are:

  • Urinary Tract Infection
  • Thirst
  • Frequent urination
  • Rash
  • Low blood sugar (hypoglycaemia)
  • Genital fungal infections

Precautions and Warnings

Pregnancy

Pregnancy

Empagliflozin+Sitagliptin can cause harm to the unborn baby if taken during pregnancy. This medicine should not be taken by pregnant women.

Breast Feeding

Breast Feeding

Empagliflozin+Sitagliptin should not be used by breastfeeding women. It is advised to consult your doctor for an alternative treatment that is safe during breastfeeding.

Driving

Driving

Empagliflozin+Sitagliptin can cause dizziness or sleepiness. Avoid driving if you have dizziness or sleepiness after taking this medicine.

Alcohol

Alcohol

Avoid excessive alcohol consumption while taking Empagliflozin+Sitagliptin. Alcohol can lower blood sugar, which may be dangerous, and excessive alcohol may increase the risk of a serious condition known as ketoacidosis.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have type 1 diabetes.
  • You experience symptoms like nausea, vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness, or a sweet smell to your breath.
  • You are at risk of dehydration, such as when you're vomiting, have diarrhoea, fever, or are unable to eat or drink, or if you're taking diuretics (water pills) or blood pressure-lowering medications.
  • You have serious kidney or liver problems.
  • You are taking other medications such as diuretics, insulin, sulphonylureas, or lithium.
  • You are pregnant or breastfeeding.
  • You experience common side effects, such as genital fungal infections or urinary tract infections.

Mode of Action

How Does It Work?

  • In Type 2 diabetes, your pancreas does not produce enough insulin to control the level of glucose in your blood, and thus your body is unable to utilise its insulin effectively. Certain proteins like sodium-glucose co-transporter-2 (SGLT2) in the kidney, helps to maintain blood sugar levels by reabsorbing glucose from urine. Empagliflozin blocks the SGLT2 protein in your kidneys. This causes an excess of blood sugar to be removed from your urine. Thereby this medicine lowers the amount of sugar in your blood.
  • Sitagliptin works by increasing insulin production in the body after a meal and decreasing sugar production.

Interactions

Interactions with other medicines

  • Tell your doctor about all the medications, supplements, or herbs you are currently taking or may take to avoid any potential interactions.
  • In particular, if you are taking medications to treat high blood pressure, heart failure, high or abnormal cholesterol levels, blood thinners, anti-infectives, antidiabetics, antihistamines, painkillers, immunomodulatory medicines, or medications for brain-related disorders.

Dosage

Overdose

If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

You should never miss your blood sugar medication, as it may lead to high blood sugar and associated symptoms. However, if you missed any dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

Frequently Asked Questions (FAQs)

No, Empagliflozin+Sitagliptin should not be used in patients with type 1 diabetes mellitus.

Empagliflozin+Sitagliptin starts acting within an hour of its oral intake. However, it may take several weeks to show its maximum effect.

The best time to take Empagliflozin+Sitagliptin is typically with meals, preferably after breakfast. It's best to take it at the same time each day to maintain consistent blood sugar control.

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