Disopyramide
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Molecule Summary
| Uses | Arrhythmia |
| Therapy | Anti-Arrhythmic |
Assurance
available
Regulated
Molecule Description
Disopyramide belongs to the class of antiarrhythmic medicines. It helps to correct abnormal and irregular rhythm of heart.
Uses
- Prevention and treatment of arrhythmias occurring after myocardial infarction
- Maintenance of normal rhythm after electro conversion e.g. atrial fibrillation, atrial flutter
- Persistent ventricular extrasystoles
- Control of arrhythmias following the use of digitalis or similar medicines
- Suppression of arrhythmias during surgical procedures e.g. cardiac catheterization
- Prevention of paroxysmal supraventricular tachycardia
Contraindications
When should one not use Disopyramide
- Known hypersensitivity to this medicine
- Those with cardiomyopathy (an acquired or hereditary disease of the heart muscle)
- Cardiogenic shock
- Patients with complete heart block
- Glaucoma (increased pressure inside the eyes)
- Predisposition to urinary retention
- Myasthenia gravis (rapid fatigue and weakness of muscles under voluntary control)
- Sinus node disease in the absence of pacemaker in children
Side effects
Common side effects of this drug are:
- Abnormal heart rhythm
- Dry mouth
- Constipation
- Urinary retention
- Blurred vision
- Double vision
- Worsening of pre-existing glaucoma (eye conditions that can cause blindness)
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- This medicine may cause low blood sugar if you have diabetes
- Tell your doctor if you have a history of:
- Heart failure
- Decreased kidney or liver function
- Nutrition problems
Mode of Action
How Does It Work?
The heart sends electrical signals which prompt the heart’s muscles to contract. With every contraction, blood is pumped all over the body. When the electrical signals are disrupted, heart pumping and the rhythmic pattern of the same are affected. This is called arrhythmia. Disopyramide helps in regulating the irregular heartbeats by inhibition of certain abnormal electrical signals generated at heart.
Interactions
Interactions with other medicines
- Other antiarrhythmic agents
- Phenytoin
- Antimuscarinic medicines
- Beta-blockers
- Verapamil
- Digitalis
- Tricyclic antidepressants
- Rifampicin
- Saquinavir
- Phenytoin
- Ketoconazole
Interactions with food items
No specific interactions with food have been reported yet.
Dosage
Overdose
Symptoms of Disopyramide overdose are loss of consciousness, fall in blood pressure, respiratory arrest, episodes of temporary cessation of breathing, conduction disturbances of the heart, arrhythmias, slowing down of heartbeats and seizures. In case of an overdose, seek emergency medical care immediately.
Missed a Dose
If you missed any dose, take it as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one.
Frequently Asked Questions (FAQs)
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