Dinoprostone

Uses	Inducing labour in pregnant women
Therapy	Drugs Acting On Uterus
Side Effects	Increased uterine contractions, Vomiting, Flushing of the skin, Back pain, Foetal distress, Diarrhoea

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Molecule Description

Dinoprostone is a medication for inducing or starting labour in women who can give birth to a full-term baby. The medicine softens and widens the cervix or lower end of the uterus, making it easier for the baby to pass through. Dinoprostone works by widening the birth canal or cervix and forcing the uterus to contract so the baby can pass through.

Uses

As per CDSCO, Dinoprostone is used to induce labour in pregnant women.

Contraindications

When should one not use Dinoprostone

If you are allergic to the medicine or its oxytocic agents
If you are hypersensitive to prostaglandins
If you have a history of major uterine surgery or caesarean section (C-section)
If you have hypertonic or hyperactive uterine patterns
If you have a history of difficult labour or delivery
If you do not have an indication of vaginal or normal delivery

Side effects

Common side effects of this drug are:

Increased uterine contractions
Vomiting
Flushing of the skin
Back pain
Foetal distress
Diarrhoea

Precautions and Warnings

Pregnancy

Dinoprostone is used in pregnancy only to start labour in a hospital or clinic, under your doctor's supervision. Animal research has shown little or no adverse effects on the growing foetus; however, human studies are scarce.

Breast Feeding

It is unsafe to use Dinoprostone while nursing. According to minimal human research, the medicine shall transfer into breast milk and harm the newborn.

Driving

Dinoprostone can cause uterine contractions, leading to childbirth. Driving a car under such circumstances will be extremely dangerous.

Alcohol

Do not drink alcohol if you have been prescribed Dinoprostone. If you have already consumed alcohol, tell your healthcare practitioner.

Other General Warnings

Talk to your doctor if

You will use Dinoprostone only at a hospital or clinic.
You should lie down for nearly half an hour to keep the medicine in place. Your doctor will help you with the application and precautions.
You shall have any second dose only as per your healthcare practitioner's advice.
You will be under observation by your medical practitioner to ensure that the contractions do not grow too powerful and that the baby is not disturbed.
You have heart, renal, lung, or liver illness or a history of asthma.
You have genital herpes.

Mode of Action

How Does It Work?

Dinoprostone is identical to E2 prostaglandin, a natural chemical made by the body as labour begins. It works by widening the birth canal or cervix and forcing the uterus to contract so the baby can pass through.

Interactions

Interactions with other medicines

Dinoprostone may interact with the following medicines and increase the risk of side effects.
Oxytocic medicines like Oxytocin and Carbetocin
Ergot alkaloids such as Methylergonovine and Ergonovine

Dosage

Overdose

If you feel you have an overdose, call your doctor right away.

Missed a Dose

Since there is no self-application for Dinoprostone, there are no chances of a missed dose. Your medical examiner shall offer the second dose in critical situations.

Frequently Asked Questions (FAQs)

Please clarify with your physician if you have had a previous preterm birth, c-section, or cervical surgery before starting Dinoprostone. Provide your practitioner with a thorough medical history to minimise difficulties.

No. It would be best if you had the second dose of Dinoprostone according to the doctor's instructions for dosage and frequency. It may produce foetal distress or birth difficulties if you take more than the prescribed quantity.

You will receive Dinoprostone only if your healthcare practitioner has prescribed it. The risk of significant problems after the application of this medicine is higher in women over 35. This risk is amplified in smokers.

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