Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen

Uses	To relieve persistent dry irritating cough in adult patients, nasal congestion, headache, fever, body aches and pains associated with sinusitis, flu and common cold, for symptomatic treatment of pain and fever.
Therapy	Cough Cold Preparation
Side Effects	Dizziness, Drowsiness, Blurred vision, Dry mouth and throat, Increased or decreased urination, Loss of appetite, Nausea, Diarrhoea, Sleep problems (Insomnia), Nervousness and Stomach pain.

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Molecule Description

Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen is used as a combination medicine for the symptomatic treatment of common cold and cough. Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen contains dextromethorphan, paracetamol and pseudoephedrine. Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen provides relief from symptoms such as runny nose, headache, sore throat, fever and pain.

Uses

Used for the relief of persistent dry irritating cough in adult patients.
Used for the relief of nasal congestion, headache, fever, body ache and pains associated with sinusitis, flu and common cold.
Used for symptomatic treatment of pain and fever.

Contraindications

When should one not use Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen

If you have an allergy or hypersensitivity to Dextromethorphan, paracetamol, pseudoephedrine or any other active ingredients present in the medicine.
If you are taking MAO inhibitors or have stopped taking them within the last 14 days.
If you are using other medicines containing Acetaminophen.
If you have Glaucoma.

Side effects

Common side effects of this drug are:

Dizziness
Drowsiness
Blurred vision
Dry mouth and throat
Increased or decreased urination
Loss of appetite
Nausea
Diarrhoea
Sleep problems (insomnia)
Nervousness
Stomach pain

Precautions and Warnings

Pregnancy

There are no adequate studies to confirm Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen safety and efficacy in pregnant women. Your doctor may prescribe it to you after evaluating potential risks and benefits.

Breast Feeding

Limited information is available on the use of Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen during breastfeeding. A higher amount of doses for a longer duration of time can produce side effects like sleepiness in the baby. Please consult your doctor before using this medicine while breastfeeding.

Driving

It is not advisable to drive if you are taking Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen. Undesirable side effects like decreased alertness, sleepiness, visual disturbances, and dizziness can occur, which can affect your ability to drive. Do not drive if these symptoms occur. Consult your doctor.

Alcohol

It is recommended not to consume alcohol if you are under this medication. It can increase the risk of side effects like dizziness and drowsiness.

Other General Warnings

Talk to your doctor if

You are breastfeeding, pregnant or planning to conceive.
Your symptoms do not resolve or clinical worsening of the condition.
You have long term cardiac, liver and kidney disease.
You have an addiction to alcohol or medicines.

Mode of Action

How Does It Work?

Dextromethorphan is a cough suppressant. It temporarily relieves cough caused by the common cold, the flu, or other conditions. It works by decreasing activity in the part of the brain that causes coughing. Pseudoephedrine is a nasal decongestant that narrows the blood vessels in the nose and so relieves a blocked nose. Paracetamol is a pain reliever and fever reducer.

Interactions

Interactions with other medicines

Interaction with Monoamine Oxidase Inhibitors (MAOI) like isocarboxazid, linezolid, methylene blue injection can cause an increase in the blood pressure.
Interaction with antihypertensives like beta-blockers, betanidine, guanethidine may partially reverse the hypotensive action of antihypertensive medicines.

Interactions with food items

Unless your physician suggests, there is no need to avoid any type of food or drink.

Dosage

Overdose

Do not take Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen in more than prescribed doses. Also, do not take it for more than 14 days. In case of overdosage, seek emergency medical treatment and contact your doctor immediately. Overdosing may lead to nausea, excessive drowsiness and dark coloured urine.

Missed a Dose

Take the missed dose as soon as you remember. If it's almost time for your next dose, wait until then to take medicine and skip the missed dose. Don't double the dosage to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen is not a habit-forming medicine. No habit forming tendencies were reported with this medicine.

Stop taking this medicine and consult your doctor if the pain gets worse or lasts for more than ten days.

Stop taking this medicine and consult your doctor if fever gets worse or lasts for more than three days.

Stop taking this medicine and consult your doctor if new symptoms occur.

Stop taking this medicine and consult your doctor if any redness or swelling is present.

Dextromethorphan+Pseudoephedrine+Paracetamol / Acetaminophen is not indicated for children below 12 years of age. It is indicated for adults and children over 12 years of age. It is generally safe for both adults and elderly patients. Since elderly patients are more prone to systemic diseases like liver and kidney impairments, dose adjustments and review is necessary.

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References:

Dextromethorphan: Fatal intoxication with associated toxicities: case report. React Wkly [Internet]. 2018 [cited 2026 Jun 7];1707(1):113–113.

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