Dexrabeprazole

Uses	Acid reflux disease, heart burn, chest discomfort, acidity
Therapy	Antacid
Side Effects	Nausea, headache, diarrhoea, stomach pain, dry mouth

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Molecule Description

Dexrabeprazole is used for relieving acidity and heartburn in conditions such as stomach and intestinal ulcers, acid reflux disease and Zollinger-Ellison Syndrome. It is categorized under the class of medicines called 'Proton pump inhibitor' medications used to reduce the amount of acid produced in the stomach. You should take this medicine preferably in the morning, 30 minutes before meals.

Uses

For the treatment of heartburn and chest pain due to stomach acid reflux disease in which acidic content from the stomach rises to the food pipe and mouth.
Treatment of ulcers of stomach, intestine and inflammation and erosion of food pipe due to stomach acid.
Management of a condition of increased gastric acid production induced by a tumour of the intestine or pancreas, also known as Zollinger-Ellison syndrome.

Contraindications

When should one not use Dexrabeprazole

If you are allergic to dexrabeprazole, rabeprazole or any other ingredients of this medicine.
If you are pregnant or think that you could be pregnant or breastfeeding.

Side effects

Common side effects of this drug are:

Sleeplessness
Headache
Dizziness
Cough
Runny nose
Sore throat
Diarrhoea
Vomiting
Nausea
Stomach pain
Constipation
Gas
Back pain
Weakness
Tiredness

Precautions and Warnings

Pregnancy

You should not take Dexrabeprazole during pregnancy. If you think you may be pregnant and happen to be taking this medicine, consult your doctor as soon as possible.

Breast Feeding

You should not take Dexrabeprazole if you are breastfeeding. Your doctor will prescribe you safer alternatives.

Driving

There are chances of drowsiness and dizziness with Dexrabeprazole. Therefore, it is not advisable to drive or use heavy machinery while taking treatment with this medicine.

Alcohol

Drinking alcohol when you are taking Dexrabeprazole does not affect the way this medicine works. However, you must avoid drinking large quantities of alcohol as it is known to increase acidity and can make your stomach disease worse.

Other General Warnings

Talk to your doctor if

You have a liver function problem.
You are experiencing symptoms like painful joints, skin rashes and tiredness.
You are to undergo any blood test (Chromogranin A).
You have stomach pain, indigestion and problems in swallowing.
You have a family history of stomach cancer.
You vomit food or blood or you are excreting black stools.
You have a skin reaction after taking similar medicine.
You are experiencing frequent diarrhoea.
You are expected to take this medicine for a longer duration as there are several risks associated with that.
The long term treatment with this medicine may lead to a deficiency of vitamin B12 which can produce symptoms like pale skin, sore tongue, weakness, headache, disturbed vision and irritability.
The long term treatment of this medicine may also weaken your bones or may slightly increase the risk of fracture.
In some patients with ulcers, the course of this medicine may take 1 to 3 months. Do not stop the medicine on your own.
Dexrabeprazole is not recommended for use in children.

Mode of Action

How Does It Work?

In an average healthy individual, specific cells in the stomach get stimulated and release acid after intake of food. In certain individuals, these pumps secrete an excess of acids and lead to acid-related stomach problems such as ulcers.
Dexrabeprazole blocks the activity of these micropumps in the stomach walls known as proton pumps thus acid release in the stomach decreases and this helps in the healing of ulcers and helps improve symptoms such as acidity and heartburn.

Interactions

Interactions with other medicines

Some medicines can affect the way Dexrabeprazole works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Inform your doctor about all the medicines, supplements, or herbals you are currently consuming or might consume to avoid any possible interaction.
Concomitant use of Dexrabeprazole along with medicines used to treat HIV infections like Atazanavir, Nelfinavir, Rilpivirine or use of antacids should be avoided as Dexrabeprazole may decrease the effectiveness of these medicines.
There may be higher chances of getting side effects if you are consuming a medicine containing Digoxin used to treat heart failure along with this medicine, especially in elderly patients.
Concomitant use of anticoagulants like Warfarin can increase the risk of bleeding and ulcers.
Other medicines like Methotrexate and antifungals such as Ketoconazole or Itraconazole should be used carefully, as it can alter the effects of the medicine.

Interactions with food items

Dexrabeprazole should not be taken with food or milk. You should consume it 30 minutes before food as food decreases the effectiveness of this medicine.

Dosage

Overdose

The symptoms of overdose with Dexrabeprazole are similar to the side-effects in the body. So, if you have consumed a higher dose or think you may have taken too much of the medicine, do not panic and contact your doctor as soon as possible or visit the nearby hospital.

Missed a Dose

If you forget a dose, take it as soon as possible. However, if it is nearly time for the next dose, skip the missed dose. It is strictly advised not to take a double dose to make up for the forgotten dose.

Frequently Asked Questions (FAQs)

Dexrabeprazole produces bone weakness and can increase the risk of getting fractures in elderly patients if taken in high doses for long term treatment.

Diarrhoea is a common side effect of Dexrabeprazole but sometimes can be serious. Dexrabeprazole reduces the gastric acid levels and can increase the bacterial count in the gut and can lead to infections. So consult your doctor immediately, in case of persistent diarrhoea. Your doctor will decide whether to continue or stop the medicine after clinical examination.

The long term use of Dexrabeprazole produces liver function disturbances, altered electrolyte (magnesium, calcium and sodium) levels and B12 deficiency. So if you experience symptoms like yellow skin and eyes, loss of appetite, nausea, itching, dizziness, fits, headache, irritability, tiredness or pale skin, visit your doctor as soon as possible. As you have been prescribed this medicine for a long duration, your doctor may advise frequent follow-ups and blood tests.

The absorption of vitamin B12 and storage of vitamin B12 in the body can get affected by the long term use of Dexrabeprazole. Dexrabeprazole causes a reduction in the absorption of vitamin B12 from the stomach due to its acid-reducing effect and can lead to vitamin B12 deficiency.

Yes, you can consume Dexrabeprazole on an empty stomach. You should preferably take this medicine in the morning on an empty stomach for better stomach acid regulation throughout the day.