Colchicine

Molecule Description

Colchicine acts as an antigout agent. It can be used in combination with other

medicines also.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Colchicine

It is used in the treatment of gouts, and to prevent flare-ups of gout when it is used along with other medicines like Probenecid, etc.

Contraindications of Colchicine

When should one not use Colchicine

If you are allergic to Colchicine
If you have a severe blood disorder (low white cell count/ low platelet count)
If you are a woman of childbearing age who is not using effective contraception
If you are undergoing hemodialysis (blood purification procedure done in kidney failure)
If you have kidney or liver problems

Side effects of Colchicine

Common side effects of this drug are:

Nausea
Vomiting
Stomach pain
Diarrhea
Inflammation of the mouth, sore throat
Prolonged bleeding, bruising or skin problems

Precautions and Warnings of Colchicine

Pregnancy

Can I take Colchicine during pregnancy?

Colchicine is a genotoxic (causing damage to genes) and teratogenic (capable of causing harm to the fetus/ unborn baby) medicine; hence, it is not safe during pregnancy or if you are planning to be pregnant.

Breast Feeding

Can I take Colchicine while breastfeeding?

Colchicine passes into breast milk and should not be taken by women who are breastfeeding their babies.

Driving

Can I drive if I have consumed Colchicine?

Driving while taking Colchicine is usually safe, but may cause drowsiness, (decreased alertness) or dizziness (spinning sensation) in some individuals. Do not drive if this happens to you.

Alcohol

Can I consume alcohol with Colchicine?

Alcohol increases uric acid levels, and hence, you are advised to stay away from alcohol if you are taking Colchicine or under treatment for gout.

Other General Warnings

Talk to your doctor if

Bone marrow suppression (a decrease in bone marrow function leading to a reduction in white blood cells)
Reduction in red blood cells and pigment (aplastic anaemia) and/or decreased blood platelet count (thrombocytopenia)
Liver, kidney, gastrointestinal and heart disease
Patients with abnormal blood counts
Elderly and weak patients
Also, regular blood tests are advised for continuous monitoring

Mode of Action of Colchicine

How Does It Work?

Colchicine acts by stopping the deposition of uric acid crystals in the joints by various mechanisms and decreases inflammation, pain, swelling, and other symptoms of gout.

Interactions of Colchicine

Interactions with other medicines

Certain antibiotics (Clarithromycin, Erythromycin and Telithromycin)
Medicines used to treat HIV/AIDS (Ritonavir, Atazanavir and Indinavir)
Cyclosporine (immunosuppressant drug used to prevent organ rejection after a transplant, psoriasis and rheumatoid arthritis)
Medicines used to treat fungal infections (Ketoconazole, Itraconazole, and Voriconazole)
Certain heart medicines (Verapamil and Diltiazem)
Disulfiram (used to treat alcoholism)

Interactions with food items

Colchicine does not interact with food, and you can take it before or after meals.

Dietary Restrictions of Colchicine

Taking grapefruit juice may lead to increased amount of Colchicine in your blood
Drink plenty of water (this flushes out uric acid from your blood)

Dosage of Colchicine

Overdose

Colchicine overdose is potentially life-threatening, especially in patients who are suffering from liver, kidney gastrointestinal, or heart disease. Inform your doctor immediately in case of an overdo...

Missed a Dose

Take the missed dose as soon as you remember. If it is time for your next scheduled dose, skip the missed dose and continue with the regular dosing; do not take extra medicine to compensate for the mi...

Q: What specific precautions should I follow while taking Colchicine?

A: Colchicine is a potentially toxic medicine. There is little difference between regular dose and overdose. Do not self-medicate, and take it exactly as prescribed by the doctor. Keep in mind the interval between two dosages and follow the dose timings precisely.

Q: How long should I take Colchicine?

A: Colchicine may be prescribed for long term use. Take this medicine as long as your doctor has suggested.

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

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परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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