Clarithromycin+Esomeprazole+Amoxycillin / Amoxicillin

When should one not use Clarithromycin+Esomeprazole+Amoxycillin / Amoxicillin

• If you are allergic to clarithromycin, esomeprazole, amoxicillin, or any of the ingredients of Clarithromycin+Esomeprazole+Amoxycillin / Amoxicillin.
• If you are allergic to antibiotics that belong to the class known as macrolide antibiotics or beta-lactam antibiotics (cephalosporin, carbapenem or monobactam).
• If you are suffering from a condition of low levels of potassium (hypokalaemia).
• If you are suffering from any kind of health condition such as liver or kidney failure.
• If you are taking medicines like blood cholesterol-lowering medicines (statins), antiviral medicine (nelfinavir), astemizole, cisapride, pimozide and terfenadine.
• If you are suffering from rhythmic defects of the heart (QT prolongation, ventricular cardiac arrhythmia).

Common side effects of this drug are:

• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Headache

Other General Warnings

• You have a history of known allergy to this medicine, any class of antibiotics or any other medicine.
• You have any pre-existing medical condition such as muscle weakness, heart disorder, kidney or liver disorder, etc.
• You experience redness of the skin followed by eruptions, swelling, irresistible itching or any kind of allergic reaction.
• You have a vitamin B12 deficiency as this medicine reduces the absorption of vitamin B12 when used for the long term, inform the doctor.
• You are suffering from severe skin infections (acute generalized exanthematous pustulosis, infectious mononucleosis).
• You are taking any other medicines which are known to cause serious disturbances in heart rhythm.
• You have/had a history of antibiotic-related diarrhoea (Clostridium difficile-associated diarrhoea).
• You are experiencing signs and symptoms of liver disease, such as loss of appetite, jaundice, dark urine, itchy skin or a tender stomach.
• You have a difficulty in passing urine.

How Does It Work?

• Clarithromycin+Esomeprazole+Amoxycillin / Amoxicillin contains clarithromycin, esomeprazole and amoxicillin.
• Clarithromycin and amoxicillin are antibiotics that work against bacterial infection. Clarithromycin, an antibiotic that works by interfering with the synthesis of important bacterial proteins while amoxicillin, a penicillin-type antibiotic prevents bacterial growth by damaging the bacterial cell wall.
• Esomeprazole relieves heartburn, acidity and indigestion by reducing the amount of acid produced in the stomach.

Interactions with other medicines

• Some medicines may affect the way Clarithromycin+Esomeprazole+Amoxycillin / Amoxicillin works or this medicine itself reduces the effectiveness of other medicines if taken at the same time.
• Inform the doctor about the medicines, supplements or herbals you are taking or might take to avoid possible interaction.
• In particular, if you are already taking medicines for bacterial and fungal infections like clarithromycin and ketoconazole, anti-HIV medicines like atazanavir, saquinavir, anti-gout medicines like probenecid, anti-tuberculosis medicines like rifampicin, etc.
• Other medicines that should be used with caution are oral contraceptives, anti-cancer medicines (like methotrexate), anti-hypertensive medicines, medicines for heart and brain-related disorders, anti-epileptic medicines, etc.
• Frequent monitoring of blood clotting parameters is required if you are taking blood thinners like warfarin. There is a risk of bleeding.

Overdose

Missed a Dose