Molecule Description

Cinacalcet is utilized in the treatment of Hypercalcemia(high levels of calcium ...
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Uses of Cinacalcet

  • The treatment of high levels of calcium in the blood
  • The treatment of high levels of parathyroid hormone in the blood due to parathyroid cancer or primary Hyperparathyroidism
  • Treatment of secondary Hyperparathyroidism (HPT) in individuals with End Stage Renal Disease (ESRD) on maintenance dialysis therapy

Contraindications of Cinacalcet

When should one not use Cinacalcet

  • Do not take if you are allergic to Cinacalcet or any ingredient of this medicine
  • Do not take if you have low calcium levels in blood

Side effects of Cinacalcet

Common side effects of this drug are:

  • Nausea and vomiting
  • Allergic symptoms - itching, hives, rash, swelling of lips, face, throat, etc.
  • Muscle pain, tightness
  • Convulsion
  • Numbness around the mouth
  • Shortness of breath, rapid weight gain

Precautions and Warnings of Cinacalcet



Can I take Cinacalcet during pregnancy?
It is probably unsafe to use this medicine during pregnancy.

Breast Feeding

Can I take Cinacalcet while breastfeeding?
It is probably unsafe to use this medicine during breastfeeding.


Can I drive if I have consumed Cinacalcet?
This medicine may decrease your alertness. Do not drive unless you feel well.


Can I consume alcohol with Cinacalcet?
You must avoid too much intake of alcohol.

Other General Warnings

Talk to your doctor if
  • In case you are taking treatment for high levels of parathyroid hormone in blood
  • Your calcium levels are not monitored before beginning the treatment with this medicine and during the treatment with this medicine
  • You feel any signs of low calcium level
  • You have kidney disease, heart disease
  • Person with severe kidney disease who are not on dialysis

Mode of Action of Cinacalcet

How Does It Work?

Cinacalcet mimics calcium, thereby reducing the levels of parathyroid hormone, which in turn decreases the levels of calcium in the blood.

Interactions of Cinacalcet

Interactions with other medicines

  • This medicine has significant interactions with Atomoxetine, Brexpiprazole, Eliglustat, Tamoxifen, Iloperidone, Thioridazine, Pimozide, Vortioxetine, and Tetrabenazine and minor to moderate interactio...
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  • A patient may require to adjust the dosage of Cinacalcet if he/she initiates or discontinues the therapy with a strong inhibitor (e.g., Ketoconazole, Itraconazole, Telithromycin, Voriconazole, Ritonav...
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Interactions with food items

No information is available on interaction of Cinacalcet when taken with food, consult your doctor or pharmacist for details.

Dietary Restrictions of Cinacalcet

No information is available on dietary restrictions while you are taking Cinacalcet, consult your doctor or pharmacist for further details.

Dosage of Cinacalcet


  • The effects of an overdose may be lethal and needs immediate medical attention
  • The symptoms of overdose can be – nausea, vomiting, etc. If you happen to take an overdose of the medicine, kindly seek emergency medical care immediately

Missed a Dose

Do not take a double dose if you have missed a dose; take the next dose as soon as you remember.

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare provider before taking Cinacalcet?

  • Inform the doctor about your detailed medical, surgical and allergy history
  • Inform your physician if you have any of the following conditions:
  • Liver disease
  • Kidney disease
  • Heart disease
  • Low calcium levels in blood
  • High or low BP
  • History of seizures
  • Inform the doctor if you are pregnant, lactating, or planning a pregnancy
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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