Chlorpropamide
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Molecule Description
Chlorpropamide belongs to a class of medicines called Sulfonylureas (anti-diabetic).
Uses
Type 2 diabetes (used to control high blood sugar )
Contraindications
When should one not use Chlorpropamide
- If you are allergic to this medicine or any of the other ingredients of this medicine
- If you have sulfa medicines allergy
- Type 1 diabetes
- Diabetes Ketoacidosis
- If you have uncontrolled diabetes, for example, severe hyperglycaemia (high blood glucose), nausea, vomiting, diarrhea, rapid weight loss
Side effects
Common side effects of this drug are:
- Scaly skin
- Dizziness
- Dark-colored urine
- Lethargy
- Hemolytic anaemia (G6PD deficiency)
- Headache
- Hypoglycemia (low blood sugar)
- Nausea and Vomiting
- Indigestion
- Decreased urine output
- Muscle pain
- Confusion
- Swelling of face, ankles, and hands, itching
- Weight loss
- Irregular heartbeat
- Lightheadedness, unusual sweating
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Inform doctor if you:
- Suffer from severe kidney disease or liver problems
- Suffering from ketoacidosis (caused by excessively high blood sugars in diabetes)
- Suffering from a severe infection
- Suffering from stress or from any condition likely to make controlling your blood sugar difficult
- If you have undergone any surgeries
- If you have intolerance to some sugars
Mode of Action
How Does It Work?
In diabetes, the pancreas does not make enough insulin or your body is not properly able to use the insulin that it produces, which leads to a high level of glucose in your blood. Chlorpropamide helps to lower your blood glucose to as normal level as possible by increasing the insulin secretion from beta cells of the pancreas. It also decreases the rate of hepatic glucose production, increases insulin receptor sensitivity and increases the number of insulin receptors.
Interactions
Interactions with other medicines
- Medicines which increase urine production (Diuretics)
- Salbutamol or Terbutaline (used to treat asthma)
- Corticosteroids (used to treat a variety of conditions, such as severe inflammation of the skin or in asthma)
- Medicines used to treat pain and inflammation (NSAID such as Ibuprofen and Celecoxib)
- Certain medicines for the treatment of high blood pressure (ACE Inhibitors and Angiotensin II Receptor Antagonists, Verapamil)
- Medicines used to treat infections (Rifampicin, Trimethoprim, Isavuconazole)
- Medicines used to treat heartburn (Cimetidine)
- Medicines used to treat HIV/AIDS (Dolutegravir)
- Medicines used to treat heart conditions such as angina (Ranolazine)
- Medicines used to treat different types of cancers
Interactions with food items
The patient should avoid excess sugar, oily food, packed food, frozen food, etc.
Dosage
Overdose
- The symptoms of overdose include shakiness, sweating, a fast-paced heartbeat, seizures, or a loss of consciousness, very low blood sugar. Doctor consultation is required.
Missed a Dose
If you forget to take a dose, follow the regular dosage schedule. Do not take a double dose.
Frequently Asked Questions (FAQs)
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