Blonanserin

Uses	Schizophrenia, Mania
Therapy	Anti-Psychotics
Side Effects	Sleepiness, inability to stay still, involuntary muscle contractions, tremors, parkinsonism, anxiety, urinary retention, weight gain

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Molecule Description

Blonanserin is an antipsychotic medication used to treat people suffering from mental illnesses such as Schizophrenia and Bipolar disorder by modifying the balance of specific chemicals in the brain. It is used orally.

Uses

According to CDSCO, Blonanserin is used in
The treatment of Schizophrenia
The treatment of Manic disorder

Contraindications

When should one not use Blonanserin

If you are allergic to Blonanserin or any ingredient of this medicine.
If you are diagnosed with liver disorders.
If you've had epilepsy or seizures.
If you have kidney disease.
If you have heart disease.

Side effects

Common side effects of this drug are:

Sleepiness
Inability to stay still
Involuntary muscle contractions
Tremors
Parkinsonism
Anxiety
Urinary retention
Weight gain

Precautions and Warnings

Pregnancy

It's possible that taking Blonanserin while pregnant is dangerous. Animal studies have revealed harmful effects on the foetus, but human research is sparse.

Breast Feeding

There is no information on the use of Blonanserin while nursing. Please seek medical advice before taking Blonanserin.

Driving

You may feel dizziness or sleepiness with this medication. Do not drive or engage in any activity that needs concentration until you better understand how it affects you.

Alcohol

Alcohol interaction with Blonanserin states alcohol consumption is not safe with this medication. Doctors advise that patients taking this medication should not consume alcohol. Blonanserin is an antipsychotic that might produce significant sleepiness when combined with alcohol. This can result in slips and falls. In addition, alcohol consumption can exacerbate mania, despair, and anxiety. Talk to your neuropsychiatrist about any concerns you have.

Other General Warnings

Talk to your doctor if

You must not give this medication to children. The efficacy of Blonanserin in children below 18 years of age is not known.
You have a history of suicidal thoughts in the past.
You must give Blonanserin to elderly or bedridden patients with caution.
You have had pneumonia.
You have low blood pressure.
You have heart disease.
Your kidney functions are closely monitored if your renal functions are compromised.

Mode of Action

How Does It Work?

This medicine is a second-generation antipsychotic. It binds to and inhibits the dopamine receptors. It also binds to the serotonin receptor, with high affinity. It has a poor affinity for other neurotransmitter receptors. Thus, causing dopaminergic and serotonergic neurotransmission to be reduced. It modulates chemical messengers serotonin and dopamine in the brain and reduces the symptoms.

Interactions

Interactions with other medicines

Sedating medicines such as antihistamines taken with Blonanserin can exaggerate the sedative effects.
Antihypertensive medications like atenolol & bisoprolol, when taken with Blonanserin, can fluctuate cardiac functions. This interaction can be fatal.
Parkinson's medication such as Levodopa can interact significantly with Blonanserin.

Dosage

Overdose

The overdose symptoms of Blonanserin include dystonia, sedation, sialorrhea, slurring of speech, or tremors. In case of overdose, immediately rush to the emergency centre near you.

Missed a Dose

If you forget to take a dose of Blonanserin, make sure to obtain it as soon as possible. Skip the missed dosage of Blonanserin, return to the regular schedule if the dose is delayed and it's time for the next dose. Do not take a double dose of Blonanserin to make up for the missed one.

Frequently Asked Questions (FAQs)

Blonanserin is known to cause somnolence (sleepiness). Avoid driving and engaging in strenuous activity during therapy with Blonanserin. If you have trouble sleeping while taking Blonanserin, you should consult your mental health consultant.

Blonanserin is not addictive, but if you suddenly stop using it, you may experience unpleasant physical symptoms.

Blonanserin, like many other medications, does not work immediately. After a few weeks of using this prescription, you may notice yourself as a more calm and relaxed person.

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