Apalutamide

• Apalutamide is used to treat adult men with:
• Metastatic Castration-Resistant Prostate Cancer (M-Crpc) Non Metastatic, Castration Resistant Prostrate Cancer (Nm-Crpc)

When should one not use Apalutamide

• If you are allergic to apalutamide or any of the other ingredients in this medicine, as a serious allergic reaction may occur

Common side effects of this drug are:

• Fatigue (tiredness)
• Skin rash, which may be itchy or widespread
• High blood pressure (hypertension)
• Hot flushes
• Joint pain (arthralgia)
• Diarrhoea
• Weight loss
• Decreased appetite
• Falls
• Fractures (broken bones), including hip, spine and rib fractures
• Low white blood cell count (leukopenia), which may increase the risk of infection
• Underactive thyroid gland (hypothyroidism)
• High cholesterol and triglyceride levels in blood tests
• Changes in taste (dysgeusia)
• Stroke or other ischaemic cerebrovascular events
• Ischaemic heart disease, including angina or heart attack
• Itching (pruritus)
• Muscle spasms
• Serious side effects can include seizures, severe skin reactions, lung inflammation (interstitial lung disease/pneumonitis), and serious heart or blood-vessel problems.
• Contact your doctor promptly if you develop a seizure, severe or rapidly worsening skin rash, difficulty breathing, chest pain, or symptoms suggestive of a stroke.

Other General Warnings

• Develop a skin rash, particularly if it is widespread, severe, or worsening.
• Experience a seizure.
• Develop a new or worsening cough or difficulty breathing.
• Have chest pain or symptoms of a heart or blood-vessel problem.
• Have a history of falls or fractures, or are at increased risk of falls or fractures.
• Have a history of seizures or other conditions that may increase your risk of seizures.
• Take other prescription medicines, over-the-counter medicines, or herbal products, as apalutamide can interact with many medicines.
• Are planning to have children in the future, as apalutamide may impair male fertility. Discuss family planning and contraception with your doctor.
• Take apalutamide at the same time every day to maintain a consistent dosing schedule.
• Swallow the tablets whole with water. Do not crush or split the tablets.
• Tell your doctor if you develop a skin rash. Seek prompt medical attention if the rash is severe, widespread, worsening, or associated with fever, flu-like symptoms, mouth sores, or other concerning symptoms.
• Contact your doctor immediately if you experience a seizure.
• Take appropriate steps to reduce your risk of falls and fractures. Your doctor may assess your bone health and recommend appropriate treatment if needed.

How Does It Work?

Interactions with other medicines

• Tell your doctor about all medicines, vitamins, supplements, and herbal products you take.
• Apalutamide can affect the way many other medicines work by increasing their breakdown in the body. Your doctor may therefore need to monitor or adjust some medicines, including certain blood thinners, heart medicines, cholesterol-lowering medicines, and seizure medicines.

Interactions with food items

Overdose

Missed a Dose