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Molecule Description

Agomelatine is very much useful in the treatment of depression.

Uses of Agomelatine

It is used for the treatment of depression

Contraindications of Agomelatine

When should one not use Agomelatine

  • Allergic to this medicine or Fluvoxamine
  • Along with the antibiotic, Ciprofloxacin
  • Liver impairment

Side effects of Agomelatine

Common side effects of this drug are:

  • Nausea
  • Headache
  • Dizziness
  • Fatigue
  • Anxiety
  • Back Pain
  • Excessive sleepiness or sleeplessness
  • Diarrhea or constipation

Precautions and Warnings of Agomelatine


Can I take Agomelatine during pregnancy?
It is probably unsafe to use this medicine during pregnancy due to the limited information available for the use of this medicine in pregnant women.

Breast Feeding

Can I take Agomelatine while breastfeeding?
There is limited information available for the use of this medicine while breastfeeding. Hence it is better to avoid.


Can I drive if I have consumed Agomelatine?
Caution is advised, as taking this medicine may lead to dizziness or sleepiness.


Can I consume alcohol with Agomelatine?
Do not drink alcohol when taking this medicine. It may make you more tired, dizzy, and sleepy than usual.

Other General Warnings

Talk to your doctor if
  • In case if you are suffering from symptoms that interfere with daily functioning (dementia), your doctor will make an individual evaluation of whether it is right for you to take Agomelatine
  • Diabetes
  • Liver disease or any drugs affecting liver function
  • Any other psychiatric disorder
  • You have high-risk factors including under-active thyroid or excessive use of alcohol or if you are smoking more than 15 cigarettes/day.
  • You should inform your doctor before surgery regarding all the products you use (including prescription medicines, non-prescription medicines, and herbal products)
  • Discuss with your doctor if you have an intolerance to some sugars. This drug may contain lactose.

Mode of Action of Agomelatine

How Does It Work?

It works by normalizing the sleep-wake cycle, which is usually disturbed in depression.

Interactions of Agomelatine

Interactions with other medicines

  • This medicine may interact with other drugs used for the treatment of depression, like Fluvoxamine
  • Antibiotics like Ciprofloxacin, Enoxacin
  • Medication for the treatment of blood pressure like Propranolol

Interactions with food items

There has not been any report for interaction with food.

Dietary Restrictions of Agomelatine

No information is available on interactions of Agomelatine when taken with food, consult your doctor or pharmacist for further details.

Dosage of Agomelatine


The effects of an overdose may be lethal and need immediate medical attention. The symptoms of overdose can be – nausea, vomiting, dizziness, fatigue, anxiety, extreme sleepiness, etc. If you take an overdose of the medicine, kindly seek emergency medical care immediately.
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Missed a Dose

Take the missed dose as early as you remember. If it is very close to the time of next dose, do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)


Q: What should I inform to healthcare provider before taking Agomelatine?

  • Inform the doctor about your detailed medical and surgical history
  • Inform your physician if you have any of the following conditions - Any other psychiatric disorders such as mania, hypomania, or bipolar disorder (characterized by experiencing periods of abnormally high excitability and emotions), diabetes, liver disease, suicidal thoughts
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Q: When and how to consume the medicine?

A: Take this medicine exactly as your physician has prescribed.

Q: Is there any special warning related to this drug?

A: Be vigilant about signs and symptoms that your liver may not be working correctly. If you observe any of the mentioned signs and symptoms of liver problems: unusual darkening of the urine, light-colored stools, yellow skin/eyes, pain in the upper right belly, unusual fatigue (primarily associated with other symptoms listed above); seek urgent advice from a doctor who may advise you to stop taking Agomelatine.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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