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Clonazepam+Escitalopram Oxalate

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Molecule Summary

Uses
comorbid depression and anxiety
Side Effects
difficulty in sleeping, lethargy, drowsiness, dry mouth, headache, excessive sweating.
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Molecule Description

Clonazepam+Escitalopram Oxalate is used for the treatment of comorbid depression and anxiety disorder. It contains escitalopram (an antidepressant) and clonazepam (an anxiolytic). Clonazepam+Escitalopram Oxalate takes around 4-6 weeks to show its full clinical effectiveness.

Uses

  • According to CDSCO Clonazepam+Escitalopram Oxalate is used for,
  • Treatment of comorbid depression and anxiety

Contraindications

When should one not use Clonazepam+Escitalopram Oxalate

  • If you have hypersensitivity to the active or inactive components of Clonazepam+Escitalopram Oxalate.
  • If you have glaucoma
  • If you have sleep apnea
  • If you have liver impairment
  • If you have myasthenia gravis

Side effects

Common side effects of this drug are:

  • Difficulty in sleeping
  • Lethargy
  • Drowsiness
  • Dry mouth
  • Headache
  • Excessive sweating

Precautions and Warnings

Pregnancy

Pregnancy

Usually, it is not advised to take Clonazepam+Escitalopram Oxalate during pregnancy. Continuing Clonazepam+Escitalopram Oxalate throughout pregnancy could result in withdrawal symptoms and anomalies like abnormal muscle tone, difficulty breathing, lethargy, poor feeding, cyanosis, irritability, and constant crying in your baby. If you conceive during the course of Clonazepam+Escitalopram Oxalate, do not stop taking the medicine suddenly and consult your doctor at the earliest.

Breast Feeding

Breast Feeding

Clonazepam+Escitalopram Oxalate is not recommended while breastfeeding as it is secreted in breast milk and may cause side effects like restlessness, agitation, poor feeding, drowsiness in your infant. Always consult a doctor or a gynaecologist before starting this medicine during breastfeeding and nursing.

Driving

Driving

You should avoid driving if you have taken Clonazepam+Escitalopram Oxalate, as it may decrease your mental alertness and cause sedation and confusion.

Alcohol

Alcohol

You should absolutely abstain from alcohol during the course of Clonazepam+Escitalopram Oxalate, as dangerous side effects such as agitation, seizures or fits, breathing difficulties, and blurring of vision can occur.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have blurred vision or coloured halos
  • You experience sexual dysfunction
  • You have fits during the course of your treatment
  • You have difficulty in breathing
  • You experience yellowing of skin or jaundice after starting this medicine
  • You experience disorientation to time, place or person
  • You suffer from epilepsy or fits
  • You have low serum sodium
  • You have recently had a heart attack

Mode of Action

How Does It Work?

Escitalopram belongs to the antidepressant class of medications that increase serotonin, a neurotransmitter or brain chemical. Clonazepam, being an anxiolytic, acts by enhancing the inhibitory effect caused by GABA or gamma-aminobutyric acid (brain chemical or neurotransmitter), causing sedation, anxiolysis, and muscle relaxation. It takes 4-6 weeks for Clonazepam+Escitalopram Oxalate to show complete clinical effectiveness.

Interactions

Interactions with other medicines

  • Clonazepam+Escitalopram Oxalate may interact with the following medications; therefore, it is critical that you inform your consulting physician about any medications or health supplements you are on:
  • Strong painkillers like codeine, methadone, oxycodone, pethidine, or tramadol- may cause sedation and difficulty in breathing.
  • Antidepressants such as selegiline, phenelzine, and rasagiline- concurrent administration may lead to serotonin syndrome.
  • Antipsychotics and antidepressants (aids in the treatment of mental health issues) like fluvoxamine, sertraline, clozapine, and buspirone- can increase the risk of developing serotonin syndrome if co-administered.
  • Blood thinners like warfarin and heparin- can increase the risk of bleeding.
  • Anti-seizure medicines like carbamazepine- escitalopram can reduce their anti-epileptic properties.
  • Pimozide, a medicine used to control abnormal tics movement- may cause fatal arrhythmia.

Interactions with food items

  • You can continue with your normal diet with Clonazepam+Escitalopram Oxalate unless instructed otherwise.
  • Try to avoid having too much tea, coffee, and other caffeine-containing products like energy drinks, as it may reduce the calming effect of Clonazepam+Escitalopram Oxalate.
  • Avoid consuming alcohol during the course of Clonazepam+Escitalopram Oxalate as it may cause sedation and difficulty in breathing.

Dosage

Overdose

In case of an overdose of Clonazepam+Escitalopram Oxalate, you may experience certain symptoms like fits, blackouts, difficulty in sleeping, drowsiness, dizziness, nausea, and vomiting. Keep your family or caregiver up to date on your medications and any potential side effects. If the patient is unconscious, collapses, has difficulty breathing, seizures, or cannot be woken, they should be immediately taken to the emergency department.

Missed a Dose

Take the missed dose of Clonazepam+Escitalopram Oxalate at the earliest. However, if the gap is too long or it is almost time for your next dose, skip the one you have missed and continue with the regular dosage schedule. Never increase the doses unless prescribed by a doctor.

Frequently Asked Questions (FAQs)

No, Clonazepam+Escitalopram Oxalate has no effect on contraceptive pills, including emergency contraceptives.

Clonazepam+Escitalopram Oxalate is usually tapered for a few weeks before stopping. Once started, you should avoid abruptly stopping this medicine as you may experience certain side effects such as difficulty sleeping, agitation, headaches, drowsiness, dizziness and numbness in hands and feet. Always consult your physician before stopping this medicine.

Dosage modifications may be required depending on the severity of liver or kidney disease. You should consult your treating physician and avoid altering the recommended dose.

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