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molecule

Zuclopenthixol

Molecule Description

Zuclopenthixol is used to treat psychiatric disorders involving thinking and be

havioural disorders. It belongs to a class of medicines called ‘typical antipsychotics.’

uses

Uses of Zuclopenthixol

  • Treatment of psychiatric disorders (psychoses), especially schizophrenia
  • Schizophrenia is a long-standing mental disease affecting a person's feelings, thoughts and behaviour. The affected person may start believing unreal things to be real (hallucinations), not accepting ...
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contraindications

Contraindications of Zuclopenthixol

When should one not use Zuclopenthixol

  • In patients with allergy to Zuclopenthixol or any components of the medicine
  • Low blood pressure or decreased consciousness due to alcohol or any medications
  • Coma
sideEffects

Side effects of Zuclopenthixol

Common side effects of this drug are:

  • Fast or slow and irregular heartbeats
  • Feeling drowsy or dizzy, spinning of the head, fainting, headache, migraine
  • Tingling or numbness of hands and legs, tremors, loss of balance or co-ordinated muscle movements (including eyes, mouth, tongue), poor memory or concentration, change in the way you walk, speech prob...
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  • Reduction in blood platelets (increased risk of clotting)
  • Breathing difficulty, blocked nose
  • Fits, vision problems, dry mouth, stomach pain, indigestion, vomiting, wind in the stomach, loose motions, constipation, increased or decreased urination, increased sweating
  • Itching, skin rashes, skin color changes, easy bruising, red and warm skin
  • Poor control of blood sugars and cholesterol
  • Weight loss or gain, generalized weakness, tiredness, fever or reduced body temperature, depression, anxiety, nervousness, sleeplessness, abnormal dreams, and nightmares, lacking interest
  • Enlarged liver, altered liver function tests
  • Unexpected breast milk secretion, menstrual problems, dry vagina, male breast enlargement, prolonged erection or ejaculation issues, changes in sex drive
  • Swelling, pain or redness in the legs, due to blood clots (uncommon, but serious)
  • High fever, confusion, muscle stiffness, sweating, and altered consciousness (neuroleptic malignant syndrome), uncontrolled movements, especially of the mouth, lips, and tongue (tardive dyskinesia), c...
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  • Severe allergic reactions like swelling of face, lips and throat with swallowing and breathing difficulty with or without rashes, itching, skin blisters (rare, but serious)
precautionsAndWarnings

Precautions and Warnings of Zuclopenthixol

pregnancy

Pregnancy

Q:
Can I take Zuclopenthixol during pregnancy?
A:
Zuclopenthixol should be used with caution in the first six months (2 trimesters) of pregnancy, only if alternatives are not available. This medicine should not be used in 3rd trimester or last three months of pregnancy as it can harm the baby.
breastfeeding

Breast Feeding

Q:
Can I take Zuclopenthixol while breastfeeding?
A:
Minimal amounts of Zuclopenthixol is secreted in breast milk and there is no reason to avoid breastfeeding if the doctor feels that treatment is necessary. Kindly note that the breastfed infant needs to be observed strictly for the first four months of birth if the mother is taking Zuclopenthixol.
driving

Driving

Q:
Can I drive if I have consumed Zuclopenthixol?
A:
Zuclopenthixol may not affect your ability to drive. In the presence of symptoms such as reduced alertness or vision problems, do not operate any machines.
alcohol

Alcohol

Q:
Can I consume alcohol with Zuclopenthixol?
A:
Alcohol can cause drowsiness and increase some of the side effects of Zuclopenthixol and should be avoided.
otherGeneralWarnings

Other General Warnings

Talk to your doctor if
  • Personal or family history of irregular heartbeats (slow heart rates), low potassium or magnesium levels and recent heart attacks associated with swelling of hands and legs, and breathing difficulty
  • Respiratory diseases causing breathing problems (asthma, bronchitis)
  • History of or at risk for seizures (fits)
  • Conditions that affect the muscles (myasthenia gravis, Parkinson’s disease, etc.)
  • Enlarged prostate
  • Cancer of the adrenal gland situated above the kidney causing life threatening high blood pressure (phaeochromocytoma)
  • Increased eye pressure (glaucoma)
  • Liver, kidney or thyroid problems
  • Risk factors for brain stroke, such as high blood pressure, smoking, etc.
  • High blood sugars (diabetes), family or personal history of blood clots and tendency for clot formations
  • History of using medicines to treat psychosis (Olanzapine, Quetiapine, Risperidone, Aripiprazole, etc.)
modeOfAction

Mode of Action of Zuclopenthixol

How Does It Work?

Zuclopenthixol blocks the action of specialized substance which transmit signals in the brain (neurotransmitter) called Dopamine. The altered mental states in psychiatric illnesses are thought to be d...
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interactions

Interactions of Zuclopenthixol

Interactions with other medicines

  • Avoid:
  • Anti-psychotic medications (Olanzapine, Quetiapine, Risperidone, Aripiprazole, etc.)
  • Medicines that cause irregular heartbeats (Amiodarone, Quinidine, Sotalol, Dofetilide, Lithium, Moxifloxacin, Erythromycin, Cisapride)
  • Use with caution:
  • A specific class of anti-depressants (Amitriptyline, Imipramine, Doxepin, etc.)
  • Blood-thinning agents (Warfarin)
  • Certain cough, cold and allergy medications (Diphenhydramine, Benztropine, etc.)
  • Metoclopromide (increases stomach and intestinal movements and reduces feelings of nausea, vomiting)
  • Piperazine (deworming agent), Levodopa (Parkinson's disease – age related brain damage), Sibutramine (lowers hunger), Digoxin (for heart rhythm abnormalities)
  • Medicines that suppress the immune response (Corticosteroids - Prednisolone, Dexamethasone, etc.) that lower the blood pressure (Hydralazine, Doxazosin, Propranolol, Methyldopa, Clonidine, Guanethidin...
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  • Anti-seizure and anti-diabetic medications
  • Inform the doctor about all the medicines you are using (including prescription, non-prescription, and herbal medicines, diet supplements, vitamins, etc.)

Interactions with food items

Zuclopenthixol can be taken before or after a meal.
dosage

Dosage of Zuclopenthixol

Overdose

Overdose of Zulcopenthixol can be harmful. It can cause symptoms like excessive sleepiness, fits, convulsions, low blood pressure and temperature, slow or prolonged heartbeat, abnormal heart rhythms, ...
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Missed a Dose

  • Take the missed dose as early as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule
  • Do not take a higher or a double dose to make up for the missed dose
  • Ideally, there should be a 6-8 hour gap between two dosages

Content Details

WRITTEN BY
doctor

Dr. Arpit Verma

MBBS, MD (Pharmacology)

REVIEWED BY
doctor

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

^

Q: Is Zuclopenthixol an effective medicine for schizophrenia?

  • One of the main advantages of Zuclopenthixol is that it is available in both tablet and injection forms and is required to take less frequently and in lower doses when compared to other medicines
  • Control of the disease and tolerability is on par with other similar medicines
  • Chances of relapse or repeated occurrence of schizophrenia after stopping treatment is low with Zuclopenthixol

Q: Anything else I must know before taking Zuclopenthixol?

  • This medicine should be used with caution in patients with liver, kidney or thyroid diseases. Inform the doctor if you are anyone in your family has such disorders
  • Zuclopenthixol increases the risk for brain stroke and dose should be adjusted accordingly in patients at risk
  • Elderly patients taking this medicine should be closely monitored
  • Zuclopenthixol should be taken as prescribed by the doctor. Self-medication and self-adjusting the dose should strictly be avoided
  • The medication is available to be taken as a tablet or as an injection on a thigh or buttock. Tablets may have to be taken 2-3 times a day but injections need to be taken less frequently – once or twi...
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  • If you were taking tablets and shifted to needles, you may need to take pills for some more time along with injections
  • Zuclopenthixol medication will have to be considered for 4-6 months to achieve the desirable response
  • Zuclopenthixol should not be used in children and adolescents
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.
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