Trastuzumab

Uses	Breast cancers
Therapy	Anti-Neoplastic
Side Effects	Chills, fever, flu-like symptoms, nausea, vomiting, increased muscle tension

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Molecule Description

Trastuzumab is an anti-cancer medication used by cancer specialists to treat specific types of breast cancer. It targets a protein called HER2, which is overexpressed in certain breast cancers. By binding to HER2, Trastuzumab inhibits the growth of these cancer cells. Trastuzumab is used in various treatment settings, including early-stage breast cancer with high HER2 levels and metastatic breast cancer. It may be administered alone or in combination with other cancer treatments like chemotherapy or hormone therapy, depending on the specific type and stage of the cancer.

Uses

Trastuzumab is used by cancer specialists in the treatment of breast cancers.

Contraindications

When should one not use Trastuzumab

If you are allergic to trastuzumab or any of the other ingredients of Trastuzumab.
If you have severe breathing problems at rest due to your cancer or if you need oxygen treatment.

Side effects

Common side effects of this drug are:

Chills
Fever
Flu-like symptoms
Nausea
Vomiting
Increased muscle tension
Shaking
Headache
Dizziness
Breathing difficulties
High or low blood pressure
Heart rhythm disturbances (palpitations, heart fluttering, irregular heartbeat)
Swelling of the face and lips
Rash
Fatigue (feeling tired)

Precautions and Warnings

Pregnancy

Trastuzumab should be avoided in pregnancy. During treatment and for 7 months after treatment has ended, it is advised to use an effective method of contraception.

Breast Feeding

Trastuzumab can pass into breast milk, which could potentially harm a breastfeeding baby. Therefore, it's strongly recommended to avoid breastfeeding during Trastuzumab treatment and for 7 months after the last dose of the medication.

Driving

Trastuzumab treatment may affect your ability to drive or operate machinery. If you experience side effects like dizziness, sleepiness, chills, or fever during treatment, avoiding driving or operating machinery is crucial until these symptoms subside.

Alcohol

No known interactions with alcohol.

Other General Warnings

Talk to your doctor if

You have ever had or might now have a hepatitis infection.
You have a history of cardiac conditions, such as heart failure, coronary artery disease, or arrhythmias.
You have previously received anthracycline-based chemotherapy.
You experience symptoms of cardiac dysfunction, including shortness of breath, fatigue, or swelling.
You have poorly controlled hypertension or other cardiovascular risk factors.
You have a history of myocardial infarction, angina requiring treatment, or clinically significant valvular disease.
You suffer from asthma or other respiratory conditions.
You develop symptoms during or after infusion, such as shortness of breath, wheezing, hypotension, hypertension, urticaria, or chest pain.
You experience delayed infusion-related symptoms hours or days after treatment.
You have dyspnoea (difficulty breathing) at rest due to advanced malignancy or other comorbidities.
You experience any new or worsening respiratory symptoms, such as cough, chest tightness, or difficulty breathing.
You have been treated with Trastuzumab before and are considering re-treatment.
You are pregnant, planning a pregnancy, or breastfeeding.
You experience severe side effects, including persistent nausea, fatigue, or signs of infection.
You notice worsening symptoms or develop new symptoms during treatment.
You are taking other medications, especially those known to affect the heart or lungs, such as taxanes, gemcitabine, or radiation therapy.

Mode of Action

How Does It Work?

Trastuzumab is a targeted cancer therapy that specifically targets cancer cells overproducing the HER2 protein. By attaching to HER2, it inhibits cell growth and division. It enhances the immune system's ability to recognize and eliminate these cancer cells. Trastuzumab primarily affects HER2-positive cancer cells, minimising its impact on healthy cells, and making it a valuable treatment option for these cancers.

Dosage

Overdose

Your doctor or nurse will give Trastuzumab. Therefore, the chances of overdose are very rare. If you experience the symptoms right after receiving the medicine, seek medical help.

Missed a Dose

Your doctor or nurse will carefully monitor and schedule your medicine, making it unlikely for a dose to be missed. However, if you suspect a dose might have been overlooked, let them know immediately.