Tofisopam

Uses	Anxiety and alcohol withdrawal symptoms
Therapy	Anti-Anxiety
Side Effects	Nausea, Stomach discomfort, Dry mouth, Skin Rash, Insomnia (Sleeplessness), Vomiting, Drowsiness, Loss of appetite, Constipation

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Molecule Description

Tofisopam is an anti-anxiety medicine primarily used to treat anxiety disorders. Anxiety disorder is a mental illness defined by excessive dread or worry that interferes with daily activities.

Uses

Anxiety disorder, characterised by excessive dread, tension, concern, panic, and other symptoms.
Alcohol Withdrawal Symptoms (Headaches, nausea, tremors, anxiety, hallucinations).

Contraindications

When should one not use Tofisopam

Hypersensitivity to tofisopam
Hereditary galactose intolerance
Breastfeeding
Pregnant

Side effects

Common side effects of this drug are:

Nausea
Stomach discomfort
Dry mouth
Skin Rash
Insomnia (Sleeplessness)
Vomiting
Drowsiness
Loss of appetite
Constipation

Precautions and Warnings

Pregnancy

Tofisopam is a Category D pregnancy risk medication that is not recommended for use by pregnant women. Because Tofisopam can negatively affect the unborn child (foetus), consult your doctor before consuming the medicine.

Breast Feeding

Unless absolutely required, Tofisopam should not be used by breastfeeding women. Before using Tofisopam, talk to your doctor about all of the dangers and benefits. Your doctor may advise you to stop taking medicine or stop nursing based on your clinical situation.

Driving

Dizziness, drowsiness, and visual abnormalities are common side effects of Tofisopam, which may impair your ability to drive or operate machinery. So, if you feel sleepy or dizzy after taking Tofisopam, don't drive or operate heavy machinery.

Alcohol

To avoid unpleasant side effects such as drowsiness, dizziness, or tiredness, you should not drink alcohol while taking Tofisopam. If used with too much alcohol, it can cause a life-threatening condition called coma.

Other General Warnings

Talk to your doctor if

You have respiratory diseases.
You have glaucoma (an eye condition).
To avoid becoming addicted to Tofisopam, only take it in the amounts suggested by your doctor. Self-medicating is not a good idea.
Because the safety and efficacy of this medicine have not been clinically verified, it is not advised for use in children under 18.
In some cases, your doctor may prescribe this medicine for reasons other than those listed above, especially if other medications aren't working.

Mode of Action

How Does It Work?

Tofisopam is an anti-anxiety medicine. It acts by enhancing the action of GABA (gamma-amino-butyric acid), a chemical messenger that regulates excessive and aberrant nerve cell activity in the brain. As a result, stress is reduced, a sense of well-being is created, anxiety is relieved, sleep is improved, and energy levels are increased, allowing you to do daily activities. As a result, life quality improves.

Interactions

Interactions with other medicines

Tofisopam may interact with:
Steroid (betamethasone)
AIDS medicines (abacavir)
Hepatitis-B medicine (adefovir)
Antiemetic and Antipsychotic drugs (amisulpride)
Antidepressants (amitriptyline)
Benzodiazepines (alprazolam, bromazepam, diazepam, lorazepam)
Anti-anxiety or antiepileptic medicines (like carbamazepine, fluvoxamine, phenobarbital, phenytoin, primidone)
Antifungal drugs (ketoconazole, itraconazole, voriconazole, fluconazole)
Acidity medicine (aluminium hydroxide, calcium carbonate, omeprazole, cimetidine)
Immuno-suppressant (cyclosporine)
Heart medicines (digoxin, digitoxin, isoniazid)
CNS stimulants (Amphetamines)
Parkinson's drug (Entacapone)

Interactions with food items

A multivitamin, multimineral, or other herbal supplement may interact with Tofisopam. Please inform your doctor if you are utilising any OTC (over the counter) medications, that is medicine that you can buy without a prescription. Also, stay away from alcoholic beverages and caffeine-containing liquids like tea and coffee.

Dosage

Overdose

In case of an overdose of Tofisopam, the onset of awareness impairment is relatively quick. With bigger doses, the onset is faster. Somnolence is the most well known and the first sign followed by ataxia, vertigo, impaired motor coordination and finally Central Nervous System (CNS) depression. An overdose could also lead to Grade I or Grade II coma.

Missed a Dose

If you miss taking a dose of Tofisopam, remember to do so as quickly as possible. If your next dose is approaching, skip the missing dose and resume your regular dosing schedule of Tofisopam. Do not take an extra dose to make up for a missed dose. If you've missed too many doses recently, talk to your doctor about altering or setting a new dosage plan to make up for missed doses.

Frequently Asked Questions (FAQs)

Stopping Tofisopam suddenly can cause withdrawal symptoms like nausea, aggressive behaviour, anxiety, and confusion. If you feel better, tell your doctor, and the dose will be modified accordingly.

Yes, if used for an extended period, Tofisopam might induce mental or physical dependence. As a result, only take Tofisopam in the dose and for the duration recommended by your doctor

Caffeine is a stimulant that may impair tofisopam's soothing effects. As a result, caffeine-containing beverages such as coffee, tea, and cola, as well as chocolate, should be avoided while you are on Tofisopam.

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References:

Tofisopam | C22H26N2O4 - PubChem

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