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Sunitinib

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Molecule Summary

Uses
Kidney, stomach, and bowel cancer.
Therapy
Anti-Neoplastic
Side Effects
Reduced platelets, red and white blood cells (e.g., neutrophils), shortness of breath, high blood pressure.
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Molecule Description

Sunitinib is an anticancer medicine used to treat kidney, stomach, and bowel cancer. It works by inhibiting certain enzymes that promote the growth of cancer cells, thereby reducing tumour size and slowing its progression. This medicine can be taken with or without food. Common side effects include reduced levels of platelets, red blood cells, and white blood cells (e.g., neutrophils), shortness of breath, high blood pressure, extreme fatigue, swelling under the skin and around the eyes, and a severe allergic rash. Before taking this medicine, inform your doctor if you have heart disease, liver or kidney issues, or a bleeding disorder. Many other medications can affect or be affected by this medicine, so notify your healthcare team of all drugs you are using. This medicine is not recommended during pregnancy or while breastfeeding. It is important for both males and females to use effective contraception during treatment to prevent pregnancy. Sunitinib has the potential to elevate blood pressure. Your physician may monitor your blood pressure while you are undergoing this treatment. It is not recommended for individuals under the age of 18.

Uses

Sunitinib is used in the treatment of kidney, stomach, and bowel cancer.

Contraindications

When should one not use Sunitinib

If you are allergic to sunitinib or any other ingredients of this medicine.

Side effects

Common side effects of this drug are:

  • Reduced platelets
  • Reduced red and white blood cells
  • Shortness of breath
  • High blood pressure
  • Extreme fatigue
  • Swelling under the skin and around the eyes
  • Severe allergic rash

Precautions and Warnings

Pregnancy

Pregnancy

Sunitinib should not be used during pregnancy unless the benefits outweigh the risks to the foetus. You should consult your doctor first.

Breast Feeding

Breast Feeding

You should not breastfeed during treatment with this medicine.

Driving

Driving

If you feel dizzy or unusually fatigued, exercise caution when driving or operating machinery.

Alcohol

Alcohol

It remains unclear whether it is safe to consume alcohol with Sunitinib. Please consult your doctor.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have high blood pressure. Sunitinib can raise blood pressure.
  • You have or have had a blood disease, bleeding problems, or bruising.
  • You have heart issues.
  • You have experienced abnormal changes in heart rhythm.
  • You have had a recent issue with blood clots in your veins and/or arteries.
  • You have or have had an aneurysm (an enlargement and weakening of a blood vessel wall).
  • You have or have had damage to the smallest blood vessels, known as thrombotic microangiopathy (TMA).
  • You have thyroid gland issues.
  • You have or have had pancreatic or gallbladder disorders.
  • You have or have had liver issues.
  • You have or have had kidney issues.
  • You are scheduled for surgery.
  • You have diabetes.

Mode of Action

How Does It Work?

Sunitinib inhibits specific proteins called RTKs that are involved in cancer progression. This includes factors that promote blood vessel development and tumour metastasis. By targeting these proteins, it helps to halt the growth and spread of cancer.

Dosage

Overdose

If you think you have taken more than the recommended amount of the medicine, seek medical help immediately.

Missed a Dose

Do not take a double dose to make up for a forgotten dose.

Frequently Asked Questions (FAQs)

If you need invasive dental treatment or surgery, inform your dentist about your Sunitinib treatment.

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References:

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