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Sitagliptin

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Molecule Summary

Uses
Type 2 Diabetes Mellitus
Therapy
Anti-Diabetic
Side Effects
Nausea, Headache, Muscle Pain, Rashes
3 Step Quality
Assurance
Cash on delivery
available
NPPA
Regulated

Molecule Description

Sitagliptin is an antidiabetic medicine that can inhibit an enzyme called DPP4 which is necessary for the metabolism of glucose and insulin.

Uses

Type 2 diabetes mellitus

Contraindications

When should one not use Sitagliptin

  • Do not take Sitagliptin if you have-
  • Type I diabetes mellitus
  • Allergic reaction to Sitagliptin
  • Any severe infection
  • Diabetic coma

Side effects

Common side effects of this drug are:

  • Stuffed or runny nose
  • Sore throat
  • Headache
  • Dizziness
  • Nausea, vomiting
  • Joint pain
  • Pancreatitis (severe stomach pain, nausea, vomiting) (serious side effect)
  • Constipation
  • Itching, rash
  • Swelling of hands or legs

Precautions and Warnings

Pregnancy

Pregnancy

You should not take this medicine during pregnancy. Limited information is available about its safety in pregnancy, hence do not take this medicine unless it is considered essential by a physician.

Breast Feeding

Breast Feeding

It is unknown if Sitagliptin passes into breast milk. You should not take this medicine if you are breastfeeding or plan to breastfeed without your doctor advise.

Driving

Driving

Sitagliptin is not known to have an impact on driving ability; however, dizziness and drowsiness is reported in some people Also, Sitagliptin in combination with other diabetes medicines can cause low blood glucose, which may affect your ability to drive Keep a juice or a chocolate bar in the car close to you when driving. In case you start feeling any of the above symptoms of hypoglycemia, immediately drink the juice or eat the chocolate bar

Alcohol

Alcohol

It is unsafe to consume alcohol with this medicine. Consumption of alcohol, together with this drug, may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on the quantity and frequency of alcohol consumption. Also, alcohol can increase the risk of developing the severe side effect of pancreatitis.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • An allergic reaction to Sitagliptin
  • Kidney disease
  • Gallstones
  • Pancreatitis (swelling of pancreas)
  • Rapid weight loss
  • Alcoholism or very high levels of triglycerides (a form of fat) in your blood
  • Type 1 diabetes mellitus

Mode of Action

How Does It Work?

Sitagliptin is used to lower blood sugar levels in patients with Type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin usually). It increases insulin synthesis by the pancreas, thereby reducing glucose levels. It also decreases glucagon levels, which is a counter-hormone of insulin, thus further reducing blood sugar levels.

Interactions

Interactions with other medicines

There can be an increased risk of fall in sugar levels when used in combination with Sulfonylureas (Glimepiride) or insulin. Ensure you talk to your doctor about any other drugs you might be taking.

Dosage

Overdose

You may experience slow, fast or irregular heartbeats, fainting, difficulty in breathing, dizziness, confusion, increased sweating and tremors due to sudden decrease in the blood sugar levels. Immediately consume some sugar/ glucose drink or eat a chocolate and call for emergency medical help.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compensate for a missed one. Taking double doses can be harmful as it can drop the glucose level strictly.

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