Pembrolizumab

Uses	Anticancer
Therapy	Anti-Neoplastic
Side Effects	Diarrhoea, nausea, vomiting, fatigue, itching, rash, headache, fever, cough, shortness of breath, muscle or joint pain

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Molecule Description

Pembrolizumab is an immunotherapy medication. It is used either alone or in combination with other medications to treat various types of cancer, including those affecting the lungs (non-small cell lung cancer), kidneys (renal cell carcinoma), bladder (urothelial carcinoma), stomach (gastric or gastro-oesophageal junction adenocarcinoma), liver (biliary tract carcinoma), and colon (colorectal cancer). Pembrolizumab may cause side effects such as diarrhoea, nausea, vomiting, fatigue, itching, rash, headache, fever, cough, shortness of breath, muscle or joint pain, loss of appetite, and reactions at the injection site. If any of these side effects persist, please inform your doctor. This medication should only be administered by your oncologist and must not be self-administered. Avoid using Pembrolizumab if you are allergic to it. Before starting treatment, inform your doctor about any existing liver or kidney issues, autoimmune conditions (such as ulcerative colitis or Crohn's disease), a history of organ transplants, stem cell transplants using donor cells, chest radiation, or any other medical conditions. Pembrolizumab may harm an unborn baby and is not recommended for use during pregnancy or while breastfeeding.

Uses

Pembrolizumab is used alone or in combination with other medications to treat various types of cancer. This includes cancers affecting the lungs (non-small cell lung cancer), kidneys (renal cell carcinoma), bladder (urothelial carcinoma), stomach (gastric or gastro-oesophageal junction adenocarcinoma), liver (biliary tract carcinoma), and colon (colorectal cancer).

Contraindications

When should one not use Pembrolizumab

If you are allergic to pembrolizumab or any of the other ingredients of this medicine.

Side effects

Common side effects of this drug are:

Urinary tract infection
Anaemia
Hypothyroidism
Decreased appetite
Insomnia
Headache
Cough
Dyspnoea (shortness of breath)
Diarrhoea
Nausea
Vomiting
Constipation
Abdominal pain
Rash
Pruritus (itching)
Musculoskeletal pain
Arthralgia (joint pain)
Fatigue
Asthenia (weakness)
Pyrexia (fever)
Oedema (swelling)

Precautions and Warnings

Pregnancy

Pembrolizumab may pose risks to a developing fetus during pregnancy. It is essential to discuss the risks with your doctor if you are pregnant or planning to become pregnant while undergoing treatment with this medication.

Breast Feeding

It is unclear if Pembrolizumab passes into breast milk. If you are taking this medication and breastfeeding, consult your doctor to evaluate the benefits of breastfeeding against the potential risks to your infant.

Driving

Pembrolizumab has a minor effect on the ability to drive and operate machinery.

Alcohol

No known interactions with alcohol.

Other General Warnings

Talk to your doctor if

You have immune system issues, such as Crohn's disease, ulcerative colitis, or lupus.
You have received an organ or tissue transplant, including a corneal transplant.
You have received or intend to receive a stem cell transplant that involves donor stem cells (allogeneic).
You have undergone radiation treatment to your chest area.
You have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.
You are pregnant or intend to become pregnant, as Pembrolizumab can harm your unborn baby.
You are breastfeeding or intend to breastfeed, as it is unknown whether this medicine passes into breast milk.
You are not using effective birth control and are capable of becoming pregnant during treatment or for four months after your last dose of Pembrolizumab.
You take any prescription or over-the-counter medications, vitamins, or herbal supplements.

Mode of Action

How Does It Work?

Pembrolizumab is an immunotherapy drug that aids the body's immune system in combating cancer. It functions by inhibiting a protein in cancer cells that allows them to evade detection by the immune system, thereby enabling T cells to recognise and attack the cancer.

Dosage

Overdose

Your doctor or nurse will give Pembrolizumab. Therefore, the chances of overdose are very rare. If you experience the symptoms right after taking the medicine, seek medical help.

Missed a Dose

Your doctor or nurse will carefully monitor and schedule your medicine, making it unlikely for a dose to be missed. However, if you suspect a dose might have been overlooked, let them know immediately.