Olmesartan Medoxomil+Chlorthalidone / Chlortalidone

When should one not use Olmesartan Medoxomil+Chlorthalidone / Chlortalidone

• If you are allergic to olmesartan, chlorthalidone, or any other ingredients of Olmesartan Medoxomil+Chlorthalidone / Chlortalidone.
• If you are taking any medicine containing aliskiren. If you are not sure what these medicines are, please confirm with your doctor.
• If you are pregnant.
• If you have jaundice.
• If you have problems with your gallbladder.
• If you have severe kidney disease.
• If your urine output in 24 hours is very low (less than 100ml).

Common side effects of this drug are:

• Headache
• Dizziness
• Nausea
• Stomach pain
• Diarrhoea

Other General Warnings

• You suffer from any heart diseases.
• You have problems with your kidney or liver.
• You have diarrhoea, vomiting, or are dehydrated.
• You have low blood pressure.
• You have diabetes.
• You are on treatment with high doses of water pills (furosemide, hydrochlorothiazide).
• You are on a low-salt diet.
• Your doctor has told you that you have high blood potassium levels.
• You have problems with your adrenal glands.
• You are taking other medicines to treat high blood pressure like ramipril, lisinopril, aliskiren, etc.

How Does It Work?

• Olmesartan Medoxomil+Chlorthalidone / Chlortalidone works by the combined action of both its components -olmesartan and chlorthalidone.
• Olmesartan is an angiotensin-II receptor antagonist. Angiotensin II is a chemical produced in the body which causes blood vessels to narrow, thus increasing blood pressure. Olmesartan works by blocking the effect of angiotensin II, which lowers blood pressure by relaxing the blood vessels.
• Chlorthalidone prevents the reabsorption of sodium and chloride by blocking the sodium/chloride symporter. This reduces the plasma and extracellular fluid volume which thereby lowers the blood pressure.

Interactions with other medicines

• Some medicines can affect the way Olmesartan Medoxomil+Chlorthalidone / Chlortalidone works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interactions.
• Especially if you are taking medicines to treat heart problems, or are taking other medicines to treat high blood pressure, potassium supplements, painkillers, amiloride, spironolactone, lithium, or colesevelam (used to reduce cholesterol and fatty substances in the blood).

Overdose

• Symptoms of overdose of Olmesartan Medoxomil+Chlorthalidone / Chlortalidone may include dizziness, weakness, nausea, vomiting, and low blood pressure.
• If you experience any of the symptoms or think you have taken too much Olmesartan Medoxomil+Chlorthalidone / Chlortalidone, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

• If you have missed taking any dose of Olmesartan Medoxomil+Chlorthalidone / Chlortalidone, take it as soon as you remember.
• If it is time for the next dose, skip the missed dose and continue your regular dosing schedule.
• Do not take a double dose of medicine to compensate for a missed one.