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Mifepristone

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Molecule Summary

Uses
Gynaecological conditions under medical supervision
Therapy
Drugs Acting On Uterus
Side Effects
Nausea, vomiting, cramps in stomach, vaginal bleeding
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Molecule Description

It is strictly used under medical supervision for the prescribed clinical condition. This medication is not for pregnancy of more than 10 weeks. Mifepristone is a synthetic steroid that is administered orally. It softens the cervix, contracts the uterus, and permits the uterine contents to be expelled. This medicine works by inhibiting the effect of progesterone, a female hormone required for maintaining pregnancy and generating uterine contractions, allowing for its clinical action. To get the most effect, the medicine is used in conjunction with other medications. It may take up to 48 hours for the medication to take effect, and you may have bleeding. If you have excessive vaginal bleeding or abdominal pain, consult your doctor. History of ectopic pregnancy, or current use of an intrauterine device, should be disclosed to the doctor before taking this prescription. Inform the doctor about any other medications you are taking, as it may modify the action of this medicine.

Uses

Mifepristone is used for the management of gynaecological conditions only when prescribed by your doctor.

Contraindications

When should one not use Mifepristone

  • If you have a known allergy to Mifepristone or other constituents.
  • If there is suspected ectopic pregnancy, this medicine can be fatal.
  • If you are using an intrauterine device like copper-T.
  • If you have had chronic adrenal failure, taking Mifepristone can be unsafe.
  • If you take corticosteroids, use Mifepristone only after a doctor's prescription.
  • If you have unexplained vaginal bleeding or have a haemorrhagic disorder, Mifepristone may be harmful for you.
  • This medication is unsafe during pregnancy and lactation.

Side effects

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Diarrhoea or constipation
  • Stomach cramps
  • Uterine contractions
  • Heavy menstrual bleeding
  • Infections

Precautions and Warnings

Pregnancy

Pregnancy

The use of Mifepristone while pregnant is extremely dangerous. Seek medical advice, as studies on pregnant women and animals have shown significant hazards to the developing baby.

Breast Feeding

Breast Feeding

It is not safe to use Mifepristone when nursing. The medication can pass through the breast milk and cause adverse effects in the baby.

Driving

Driving

Mifepristone can reduce the patient's attentiveness while on this medicine. Mifepristone frequently causes drowsiness that can sometimes last till the next day. As a result, if you're taking this medication, you should avoid driving.

Alcohol

Alcohol

Taking Mifepristone with alcohol is unsafe. Avoid or minimise your alcohol consumption while on this medication. Avoid jobs that need mental focus after taking this medication, like operating machinery. Dizziness, tiredness, and difficulties concentrating can all be exacerbated by taking alcohol and Mifepristone. It has the potential to reduce the patient's attentiveness while on this medicine.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have ever had an ectopic pregnancy.
  • You are breastfeeding, consult your doctor.
  • You have an intrauterine device.
  • Avoid aggressive activities such as strenuous exercise, running, or driving because they can worsen the bleeding.

Mode of Action

How Does It Work?

Mifepristone prevents hormone progesterone from acting. Progesterone is an essential hormone for a healthy pregnancy. Without this hormone, the uterus (womb) lining breaks down, much like it does after a menstrual period, and the pregnancy stops growing. By binding to receptors and sensitising the inner linings of the uterus, Mifepristone limits the effect of progesterone, causing bleeding and contractions. It also reduces the action of excess cortisol by blocking its impact on receptors.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Mifepristone works, or Mifepristone itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • In particular, if you are taking medicines like Ketoconazole, Erythromycin, Hydrocortisone, Itraconazole, Dexamethasone, Pimozide, Warfarin, Ergotamine and Glucocorticoids.

Interactions with food items

  • While using Mifepristone, avoid consuming grapefruit juice because it may increase the risk of its side effects.

Dosage

Overdose

Follow the gynaecologist's instructions on the dosage and duration of Mifepristone. Mifepristone may have to be consumed with food. Seek emergency medical treatment or contact a doctor in a suspected case of overdose. Symptoms of an overdose may include nausea, vomiting, headaches, giddiness, and abdominal cramps.

Missed a Dose

Contact the doctor if you miss a dose of Mifepristone. Do not double up doses without consulting the doctor.

Frequently Asked Questions (FAQs)

No, exceeding the advised amount of this medicine can cause negative effects like abdominal pain, indigestion, back pain, excessive vaginal bleeding, diarrhoea, vomiting, heavy bleeding, or anxiety.

Consult your doctor before using Mifepristone if you have liver disease. Your doctor will decide whether any change in dose is needed.

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