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Molecule Description

Methyldopa is useful in the treatment of high blood pressure. It belongs to the class of antihypertensives.

Uses of Methyldopa

Methyldopa is mainly used in the treatment of high blood pressure.

Contraindications of Methyldopa

When should one not use Methyldopa

  • Allergic to Methyldopa or any other excipients of the product
  • Liver disease such as acute hepatitis (inflammation of the liver) and active cirrhosis (damaged liver tissues)
  • Medication for depression called MAO Inhibitors
  • Tumors in kidney like phaeochromocytoma or paraganglioma

Side effects of Methyldopa

Common side effects of this drug are:

  • Itching, hives, rash
  • Yellowing of the skin or eyes
  • Weight gain
  • Slow heart rate
  • Nausea, low appetite, dark urine, jaundice, indicating liver damage
  • Easy bruising
  • Swelling of hands and feet
  • Weight gain
  • Head pain
  • Joint pain
  • Drowsiness
  • Weakness
  • Dry mouth
  • Diarrhea, constipation, bloating
  • Menstrual disturbances
  • Breast swelling
  • Vomiting
  • Stomach pain

Precautions and Warnings of Methyldopa


Can I take Methyldopa during pregnancy?
There were no harmful effects observed while Methyldopa was taken during pregnancy. However, the possible risks to a foetus cannot be ignored and your doctor should closely monitor you if you are taking Methyldopa while you are pregnant.

Breast Feeding

Can I take Methyldopa while breastfeeding?
Methyldopa can be taken during breastfeeding. Your doctor will tell you about the use of Methyldopa after assessing the benefits of Methyldopa over risks.


Can I drive if I have consumed Methyldopa?
Taking this medicine may cause dizziness, sleepiness or tiredness. If this happens to you, please do not drive.


Can I consume alcohol with Methyldopa?
It is advised not to drink alcohol if you are taking this medicine, consult your doctor or pharmacist for further information.

Other General Warnings

Talk to your doctor if
  • You have haemolytic anaemia (abnormal breakdown of red blood cells)
  • You have fever, abnormal liver function or jaundice the treatment should be withdrawn
  • You have a history of liver disease
  • You are taking medicines called anesthesia, the dose of anesthetics should be reduced
  • You are on dialysis and have had a history of blood pressure you may develop blood pressure again

Mode of Action of Methyldopa

How Does It Work?

Methyldopa relaxes our blood vessels and helps the heart to beat slowly, thereby decreasing the blood pressure.

Interactions of Methyldopa

Interactions with other medicines

Lithium, Phenothiazines, Tricyclic Antidepressants, MAOIs (a medicine used to treat depression) and other antihypertensive drugs.

Interactions with food items

No information is available on interactions when taken with food, consult your doctor or pharmacist for further information.

Dietary Restrictions of Methyldopa

No information is available on dietary restrictions while you are taking Methyldopa, consult your doctor or pharmacist for further details.

Dosage of Methyldopa


Overdose results in low blood pressure, excessive sedation, weakness, slow heartbeat, dizziness, light-headedness, constipation, distension, flatus (gas in or from stomach or intestine), diarrhea, nausea and vomiting.
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Missed a Dose

Do not take a double dose if you have missed the dose; take the next dose as soon as you remember.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Methyldopa?

  • Inform the doctor about your detailed medical & surgical history
  • Inform the physician about the list of medicines that you have been taking because some medicines are known to interact with this medicine
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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