Methyl Sulfonylmethane+Diacerein+Glucosamine
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Molecule Summary
| Uses | Osteoarthritis, Joint and Bone disorders |
| Therapy | Drugs For Osteoarthritis |
| Side Effects | Nausea, vomiting, headache, drowsiness, tiredness, diarrhoea, indigestion, stomach pain, rash, itching |
Medicines
available
19k pincodes
Molecule Description
Methyl Sulfonylmethane+Diacerein+Glucosamine is used in the treatment of osteoarthritis of the knee and hip joints. It is a combination medicine containing methyl sulfonyl methane (MSM), diacerein and glucosamine as the active ingredients. It reduces the pain and swelling in the joint by tackling the inflammation. Methyl Sulfonylmethane+Diacerein+Glucosamine promotes ease of movement by reducing friction between the joints. It does so by increasing the cushioning effect between the joints. It should be taken as directed by the doctor and in doses and duration as prescribed. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting Methyl Sulfonylmethane+Diacerein+Glucosamine.
Uses
Methyl Sulfonylmethane+Diacerein+Glucosamine is used to treat osteoarthritis of the knee and hip joints, especially in the initial stage of the disease.
Contraindications
When should one not use Methyl Sulfonylmethane+Diacerein+Glucosamine
- If you are allergic to glucosamine, diacerein, Methyl Sulfonyl Methane (MSM) or any other component of Methyl Sulfonylmethane+Diacerein+Glucosamine.
- If you are suffering from liver disease and/or severe kidney damage.
- If you have a history of or are suffering from obstruction of the intestine.
- If you are or were suffering from food pipe or intestinal diseases like ulcerative colitis or Crohn's disease.
- If you are prone to or are suffering from stomach ache.
- If you are allergic to shellfish.
Side effects
Common side effects of this drug are:
- Nausea
- Vomiting
- Headache
- Drowsiness
- Tiredness
- Diarrhoea
- Indigestion
- Stomach pain
- Rash
- Itching
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a history of or are suffering from liver, heart or kidney disease.
- If you have any other joint disease/ condition, find out the exact cause.
- You are suffering from diabetes or asthma.
- You are suffering from increased cholesterol levels.
- You are on antibiotics for any other medical condition, as it may increase the risk of stomach problems.
- You are pregnant, you think you may be pregnant or breastfeeding.
- You have experienced diarrhoea due to Methyl Sulfonylmethane+Diacerein+Glucosamine earlier.
- You had electrolyte imbalance or dehydration due to any other medicine in the past.
- Methyl Sulfonylmethane+Diacerein+Glucosamine is not recommended for use in children below 18 years of age.
Mode of Action
How Does It Work?
- Methyl Sulfonyl Methane (MSM) acts as a nutritional supplement to the bones. It contains sulphur which is vital in the production of collagen and glucosamine, which in turn help in strengthening and repairing the bones and joints.
- Diacerein works by blocking the actions of a chemical substance called interleukin-1 beta, which leads to swelling, pain and degradation of cartilage at the joints. It also helps in the build-up of cartilage, thereby aiding in joint repair and healing.
- Glucosamine is a chemical substance found in the fluid around the joints (synovial fluid). It helps the synthesis of synovial fluid which keeps the joints lubricated and provides better movement and flexibility. It promotes the build-up of cartilage thereby helping in joint repair and reducing pain and improving its healing.
Interactions
Interactions with other medicines
- Some medicines can affect the way Methyl Sulfonylmethane+Diacerein+Glucosamine works or Methyl Sulfonylmethane+Diacerein+Glucosamine itself can affect the action of other medicines taken at the same time.
- Tell your doctor about all the medicines you are currently taking, recently taken or might take to avoid any possible interactions.
- Particularly, if you are on medicines used to treat acidity, immunosuppressant medicines like doxorubicin, etoposide, teniposide, medicines used to treat heart failure, high blood pressure and/ or antibiotics to treat certain medical conditions.
- Patients with uncontrolled diabetes must use this medicine with caution as concomitant use of Methyl Sulfonylmethane+Diacerein+Glucosamine with antidiabetic medicine such as glipizide, glyburide and metformin may decrease the effect of blood sugar-lowering medicines.
- The use of Methyl Sulfonylmethane+Diacerein+Glucosamine with blood-thinning medicines like warfarin can increase the risk of bleeding.
Interactions with food items
It is advisable to take Methyl Sulfonylmethane+Diacerein+Glucosamine with food. This helps to minimize gastrointestinal side effects such as nausea, diarrhoea, and indigestion. Taking it after meals can improve tolerance.
Dosage
Overdose
Taking more than the recommended dosage of Methyl Sulfonylmethane+Diacerein+Glucosamine can cause headache, dizziness, confusion, joint pain, nausea, vomiting, severe diarrhoea or constipation. If you have taken too much of this medicine, then contact your doctor or reach out to the nearest hospital immediately.
Missed a Dose
If you have missed taking any dose of Methyl Sulfonylmethane+Diacerein+Glucosamine, then take it as soon as you remember. If it's already time for the next dose, then skip the missed dose and follow the regular dosing schedule.
Frequently Asked Questions (FAQs)
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References:
- Methylsulfonylmethane: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Go.drugbank.com. 2022 [cited 1 June 2026]
- Pavelka K, Bruyère O, Cooper C, Kanis JA, Leeb BF, Maheu E, Martel-Pelletier J, Monfort J, Pelletier JP, Rizzoli R, Reginster JY. Diacerein: benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO. Drugs Aging. 2016 Feb;[cited 2026 Jun 1].
- National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 76965765, Glucosamine sulfate potassium chloride. Retrieved January 23, 2025
- Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and safety of a novel dietary supplement. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290. PMID: 28384241. [cited 2026 Jun 1].
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