Mesalazine / Mesalamine / 5-Aminosalicylic Acid

Uses	Ulcerative colitis
Therapy	Drugs For Ulcerative Colitis
Side Effects	Skin rash, itching, indigestion, fever, chest pain, numbness, tingling or pricking sensation

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Molecule Description

Mesalazine / Mesalamine / 5-Aminosalicylic Acid is used in the treatment of ulcerative colitis (a condition that causes inflammation and ulcers in the lining of the large intestines) and also helps prevent the recurrence of its symptoms. It works by inhibiting certain substances in the body that may lead to inflammation. Mesalazine / Mesalamine / 5-Aminosalicylic Acid should only be taken after consulting a doctor, in doses and for the duration prescribed. It is not recommended for use in children under 6 years old.

Uses

Mesalazine / Mesalamine / 5-Aminosalicylic Acid is used in treating ulcerative colitis (a condition that causes inflammation, irritation and ulcers in your digestive tract preferably the lining of your large intestine).

Contraindications

When should one not use Mesalazine / Mesalamine / 5-Aminosalicylic Acid

If you are allergic to mesalazine or any other ingredients of Mesalazine / Mesalamine / 5-Aminosalicylic Acid.
If you have severe problems with your liver or kidney.
If you are allergic to salicylates (Diclofenac, aspirin, Ibuprofen, etc).
If your child is below the age of 6 years.

Side effects

Common side effects of this drug are:

Skin rash, itching
Indigestion
Fever
Chest pain
Numbness, tingling or pricking sensation

Precautions and Warnings

Pregnancy

You should consult your doctor before using Mesalazine / Mesalamine / 5-Aminosalicylic Acid as there is limited information about its safety during pregnancy. Your doctor will only prescribe you this medicine if considered essential after assessing the benefits over risks.

Breast Feeding

Mesalazine / Mesalamine / 5-Aminosalicylic Acid passes into breast milk in a small amount, hence you should consult your doctor. When prescribed, watch out for symptoms like diarrhoea, if your child develops it immediately discontinue breastfeeding and contact your doctor.

Driving

It is not expected that Mesalazine / Mesalamine / 5-Aminosalicylic Acid will affect your ability to drive, but sometimes this medicine may make you a little dizzy, hence you should be cautious while driving or operating machines.

Alcohol

Although there is no known interaction between alcohol and Mesalazine / Mesalamine / 5-Aminosalicylic Acid, it is essential to consult your physician if you have a habit of regular drinking.

Other General Warnings

Talk to your doctor if

You have any liver or kidney related problems.
You have any lung diseases like asthma.
You have any problems with your heart (like any allergic reactions).
You have experienced an allergic reaction while taking sulfasalazine.
You may develop kidney stones (symptoms like stomach pain, blood in urine) while on treatment with this medicine. Hence you should drink plenty of water.
Before and during treatment with Mesalazine / Mesalamine / 5-Aminosalicylic Acid, your doctor may want to monitor the liver, kidneys, blood and lungs periodically.
Mesalazine / Mesalamine / 5-Aminosalicylic Acid is not recommended for use in children less than 6 years old.

Mode of Action

How Does It Work?

Mesalazine works by preventing or blocking the body from producing certain substances that may cause inflammation.

Interactions

Interactions with other medicines

You should always tell the doctor if you are taking any other medicines, herbal preparation and supplements to avoid any interaction with Mesalazine / Mesalamine / 5-Aminosalicylic Acid.
You need to be cautious while simultaneously taking this medicine along with medicines like azathioprine, 6-mercaptopurine (used in rheumatoid arthritis, Crohn's disease), thioguanine (used in cancer treatment).
This medicine when taken along with blood thinners like warfarin (used to prevent blood clot formation) may decrease the effect of warfarin.

Interactions with food items

Mesalazine / Mesalamine / 5-Aminosalicylic Acid may be taken with or without food, but it is better to take it at a fixed time.

Dosage

Overdose

Seek urgent medical help if you feel that you have taken too much of Mesalazine / Mesalamine / 5-Aminosalicylic Acid.

Missed a Dose

In case you've missed any dose, take it as soon as you remember it. If it is almost time for the next dose, then skip the missed dose. Avoid taking a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

The dose and duration of Mesalazine / Mesalamine / 5-Aminosalicylic Acid will depend on the response to treatment. Follow your doctor's instructions and do not stop taking this medicine on your own.

No, you should not recommend Mesalazine / Mesalamine / 5-Aminosalicylic Acid to anyone. As different underlying conditions produce similar symptoms that the doctor can decide on after careful clinical examinations. This medicine also has many contraindications and side effects that ignored can lead to severe conditions. So, do not recommend self-administration. Ask them to use it only after the doctor's advice.

No, you should not stop taking this medicine until advised by the doctor, even if you are feeling good. Please reach out to your doctor if you have any issues while taking this medicine.

Inform the doctor about your detailed medical & surgical history. Inform your doctor if you have heart, liver or kidney disease. Inform your doctor if you are pregnant, breastfeeding or planning to have a baby. This medicine may interact with other medicines, hence, inform your doctor if you are taking any other medicines including supplements or herbal products. Also, inform your doctor if you are stopping any medicine.

Skin rash, itching, indigestion, fever and chest pain are a few side effects of Mesalazine / Mesalamine / 5-Aminosalicylic Acid. These can sometimes be serious. Consult your doctor if you notice any of these or if they do not go away.

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References:

National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 4075, Mesalamine. Retrieved January 24, 2025.

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