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Molecule Description

Medroxyprogesterone is a form of progesterone (a female hormone) that helps reg

ulate ovulation and menstrual cycles.


Uses of Medroxyprogesterone

  • Absent or irregular periods
  • Heavy periods (abnormal bleeding from uterus)
  • Mild to moderate endometriosis
  • Used as contraceptive
  • Uterine cancers (recurrent or metastatic)

Contraindications of Medroxyprogesterone

When should one not use Medroxyprogesterone

  • Ongoing pregnancy
  • Liver disease
  • Hormone-related tumors e.g. breast cancer, ovarian cancer
  • History of stroke
  • Known anaphylactic reaction or angioedema
  • Undiagnosed vaginal bleeding

Side effects of Medroxyprogesterone

Common side effects of this drug are:

  • Headache, dizziness
  • Feeling nervous or depressed
  • Spotting or breakthrough bleeding
  • Changes in your menstrual periods
  • Breast discharge
  • Bruising or swelling of your veins
  • Sleep disturbances
  • Itching, rash, acne, abnormal hair growth, hair fall
  • Stomach discomfort, bloating, nausea
  • Weight gain
  • Itching, hives, rash; yellowing of the skin or eyes
  • Vertigo or dizziness
  • A breast lump
  • Sleep problems
  • Dizziness
  • Mood changes
  • Fever
  • Jaundice
  • Swelling in your hands, feet
  • Chest pain, nausea, sweating
  • Signs of a stroke
  • Blood clot sign in your leg (Deep vein thrombosis (DVT))

Precautions and Warnings of Medroxyprogesterone



Can I take Medroxyprogesterone during pregnancy?
This medicine should not be used during pregnancy because it may be harmful for unborn baby.

Breast Feeding

Can I take Medroxyprogesterone while breastfeeding?
Avoided in breastfeeding women as this medicine passes into breast milk.


Can I drive if I have consumed Medroxyprogesterone?
This drug may lead to cause dizziness or drowsiness. Do not drive until you feel well.


Can I consume alcohol with Medroxyprogesterone?
Alcohol may lead to cause dizziness or drowsiness. Consult with your doctor.

Other General Warnings

Talk to your doctor if
Do not smoke. Smoking combined with this medicine may lead to increase risk factors like strokes, blood clots, high blood pressure and sometimes heart attacks.

Mode of Action of Medroxyprogesterone

How Does It Work?

Medroxyprogesterone corrects the hormonal imbalance thereby regulating ovulation and menstrual disturbances.

Interactions of Medroxyprogesterone

Interactions with other medicines

  • Aminoglutethimide, sometimes used in Cushing’s syndrome
  • Medicines for thinning the blood (e.g. Warfarin)
  • Medicines for treating convulsions (e.g. Phenobarbital, Phenytoin, and Carbamazepine)
  • Ritonavir and Nelfinavir sometimes used to treat HIV and AIDS
  • Medicines for treating infections (e.g. Nevirapine, Rifampicin, Rifabutin, Efavirenz)

Interactions with food items

This medicine is known to show certain side-effects like obesity, high cholesterol levels in blood and high blood pressure. You may be advised low fat, low salt diet while on this medication. Follow t...
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Dosage of Medroxyprogesterone


Inform your doctor immediately in case of overdose.

Missed a Dose

Take the missed dose as early as you remember. Skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Medroxyprogesterone?

  • Inform the doctor about your detailed medical & surgical history
  • Inform your physician if you have any of the following conditions:
  • Liver disease
  • Ongoing pregnancy
  • Hormone-related tumors – e.g. breast cancer
  • History of stroke
  • High BP, high cholesterol
  • Epilepsy, asthma, migraine
  • Kidney disease, thyroid disease and diabetes

Q: When and how to consume the medicine?

A: Medroxyprogesterone should be taken in the exact dose as advised by the physician. It is usually taken for few days in the month, from a particular day of the menstrual cycle. Follow the doctor’s instructions properly.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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