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Molecule Description

Hydroxyzine is an antihistaminic which is used to treat allergic reactions in adults and children.

Uses of Hydroxyzine

  • It used to relieve itching caused by allergies, urticaria, sneezing, running nose
  • It is also used in the treatment of anxiety in adults

Contraindications of Hydroxyzine

When should one not use Hydroxyzine

  • If you are allergic to Hydroxyzine or Cetirizine, other Piperazine derivatives, Aminophylline or Ethylenediamine
  • If you have any heart problems or if your heart rate is low
  • If you have low potassium or magnesium salts level in body
  • If you have had any past medical or family history of heart disease
  • If you are pregnant or breastfeeding

Side effects of Hydroxyzine

Common side effects of this drug are:

  • Feeling sleepy
  • Dry mouth
  • Stomach upset
  • Headache
  • Dizziness,drowsiness
  • Blurred vision
  • Restless muscle movements in your eyes, tongue, jaw or neck
  • Tremors (uncontrolled shaking)
  • Confusion
  • Fits
  • Constipation

Precautions and Warnings of Hydroxyzine


Can I take Hydroxyzine during pregnancy?
Do not take Hydroxyzine if you are pregnant. A limited number of studies of this medicine suggest that there might be a correlation between its use in the first trimester of pregnancy and congenital abnormalities in the fetus.

Breast Feeding

Can I take Hydroxyzine while breastfeeding?
It is unknown if Hydroxyzine is excreted into breast milk. It can cause excessive sleepiness in the breastfed babies, hence should be avoided in breastfeeding.


Can I drive if I have consumed Hydroxyzine?
Do not drive after taking Hydroxyzine as it may make you drowsy, sleepy and can make you feel less alert than usual.


Can I consume alcohol with Hydroxyzine?
Do not take alcohol along with Hydroxyzine as it can result in excessive sleepiness and drowsiness.

Other General Warnings

Talk to your doctor if
  • You have heart problems, glaucoma (increased pressure in the eye), fits
  • You experience palpitations, trouble breathing, loss of consciousness while taking this medicine then immediately seek medical attention
  • You have high blood pressure (hypertension)
  • You have myasthenia gravis (a muscle weakness disorder)
  • You have digestive system or stomach problems, difficulty in passing water e.g. due to an enlarged prostate

Mode of Action of Hydroxyzine

How Does It Work?

Histamine is a substance produced by the body. Hydroxyzine blocks the effect of these substances and controls allergy symptoms like itching, running nose, etc. It is mainly used for allergic reactions.
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Interactions of Hydroxyzine

Interactions with other medicines

  • Medicines for bacterial infections (antibiotics like Erythromycin, Moxifloxacin, Levofloxacin)
  • Medicines for heart problems or high blood pressure (like Amiodarone, Quinidine, Disopyramide, Sotalol)
  • Medicines for psychoses (like Haloperidol)
  • Medicines for depression (like Citalopram, Escitalopram)
  • Medicines for gastrointestinal disorders (e.g. Prucalopride)
  • Medicines for allergy
  • Medicines for malaria (e.g. Mefloquine)
  • Medicines for cancer (e.g. Toremifene, Vandetanib)
  • Betahistine used to treat Meniere's disease

Interactions with food items

No information is available on interactions ofHydroxyzinewhen taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Hydroxyzine

No information is available on dietary restrictions while you are takingHydroxyzine, consult your doctor or pharmacist for further information.

Dosage of Hydroxyzine


Symptoms of overdose may include slowing down the central nervous system, unconsciousness, nausea or vomiting. Call the doctor immediately if you suspect you have overdosed.

Missed a Dose

Do not take the double dose if you miss any dose. Try to take the missed dose as soon as possible unless it is almost time to the next dose.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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