Escitalopram Oxalate+Etizolam

Uses	Depression disorders, Anxiety and anxiety-related disorders, Obsessive Compulsive Disorder, Insomnia, Panic-related Disorder, Premenstrual Syndrome, Social Phobias
Therapy	Anti-Anxiety And Anti-Depressant
Side Effects	Headache, Ejaculatory Problems, Drowsiness, Sedation, Hyponatraemia, Loss of Libido, Weight Gain, Flatulence, Diaphoresis, Anorgasmia, Dizziness, Abdominal Pain

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Molecule Description

Escitalopram Oxalate+Etizolam is a medicine that contains two active ingredients, etizolam and escitalopram. Etizolam belongs to a benzodiazepine analogue called thienodiazepine which acts on the brain and nerves (central nervous system). It is a fast-acting tranquilliser that interferes with the natural state of neurotransmitters called GABA, causing calmness, anxiolytic, muscle relaxing, and sedation effects.

Uses

Depression disorders
Anxiety and anxiety-related disorders (GAD, SAD)
Obsessive-Compulsive Disorder
Insomnia
Panic-related disorders
Premenstrual syndrome
Social phobias

Contraindications

When should one not use Escitalopram Oxalate+Etizolam

If you are allergic to either etizolam or escitalopram
If you are using citalopram
If you are less than 12 years of age
If you are using MAO-inhibitor concurrently like linezolid, phenelzine, rasagiline, etc. or have used these medicines within the last 14 days
If you are taking stimulant medicines or other medicines for Parkinson's, migraine, depression, headaches
If you are taking anticoagulants
If you are taking opioids
If you have closed-angle glaucoma
If you are a chronic alcoholic
If you are taking pimozide
If you have serious liver issues
If you have low sodium levels
If you have bleeding disorders
If you have malabsorption syndromes
If you have sexual problems
If you have drug addiction problems or have suicidal tendencies
If you have manic behaviour
If you have had a heart attack in the last 30 days
If you have bleeding from the stomach, duodenum, or oesophagus
If you have serotonin syndrome - a type of disorder with high serotonin levels

Side effects

Common side effects of this drug are:

Agitation
Restlessness
Shivering
Diarrhoea
Fever
Seizures
Muscle rigidity
High blood pressure
High pulse
Confusion
Dilated pupils
Muscle twitches
Headache
Goosebumps
Irregular pulse
Ejaculatory problems
Drowsiness
Sedation
Hyponatraemia or low sodium levels
Loss of libido
Weight gain
Flatulence
Diaphoresis
Anorgasmia
Dizziness
Abdominal pain

Precautions and Warnings

Pregnancy

No, avoid taking Escitalopram Oxalate+Etizolam during pregnancy. Consult a doctor or a gynaecologist if you are planning to take an SSRI and a benzodiazepine combination.

Breast Feeding

No, avoid taking Escitalopram Oxalate+Etizolam while breastfeeding and lactation as both etizolam and escitalopram are secreted in the milk.

Driving

Avoid driving if you have taken Escitalopram Oxalate+Etizolam as it will cause sedation, drowsiness, dizziness, impaired judgement, and fainting.

Alcohol

No, avoid alcohol during the course of Escitalopram Oxalate+Etizolam as it will cause sedation, drowsiness, respiratory depression, and slow, shallow breathing.

Other General Warnings

Talk to your doctor if

You have any allergic reactions.
You experience any side effects. Keep your family members informed of your medication and make them aware of the serious side effects and when to call your doctor or emergency services.
You take Escitalopram Oxalate+Etizolam in a dosage not advised by the doctor. It should be continued for the advised period of time. It should not be stopped abruptly without consulting the doctor. Sudden withdrawal may cause adverse effects such as flu-like symptoms, insomnia, nausea, seizures, abnormal body feelings and sensation, aches and pain, anxiety and paranoia, derealisation, depersonalisation, and depression.

Mode of Action

How Does It Work?

Etizolam is a thienodiazepine of the benzodiazepine analogue which binds itself to a Gamma-aminobutyric or GABA receptor present in the postsynaptic neuron and enhances its inhibitory action. The increased neuronal excitability to chloride ion results in hyperpolarization of the neuronal membrane and stabilisation.

Interactions

Interactions with other medicines

Serotonergic Drugs like opiates, tricyclic antidepressants, triptans, MAO inhibitors
Pimozide
Non-steroidal anti-inflammatory drugs (NSAIDs)
CYP3A4 inhibitors like doxylamine, fluvoxamine, minocycline, mifepristone, etc.

Interactions with food items

Avoid alcohol while taking this medicine.
You can continue your regular diet.

Dosage

Overdose

If you have an overdose of the medicine you may experience cardiac arrhythmias, bradycardia, seizures, depression, tremors, diaphoresis, QT prolongation, fever, low blood pressure, apnoea, vomiting, and dilated pupils. In case of an overdose, call for emergency services immediately.

Missed a Dose

This medicine should be taken as prescribed by the doctor. Take the missed dose at the earliest. However if it's time for your second dose, skip the missed dose. Never take a double dose unless prescribed by the doctor.

Frequently Asked Questions (FAQs)

Escitalopram Oxalate+Etizolam decreases sodium in the body particularly due to escitalopram. This ingredient in the drug has SIADH-like activity which means that there is impaired water excretion due to low sodium levels in the body.

It can be taken if you have mild to moderate kidney disease. However, dose adjustment may be required in case of severe renal insufficiency. Always consult a doctor and keep them well informed if you have kidney disease.

Escitalopram Oxalate+Etizolam contains two main ingredients - Etizolam and Escitalopram. Etizolam takes around 30 mins - 2 hours to show its effect clinically whereas escitalopram being an SSRI takes around 4-6 weeks to show its effect.

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References:

Escitalopram

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