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Donepezil

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Molecule Summary

Uses
Alzheimer's dementia
Therapy
Drugs For Alzheimer Disease
Side Effects
Nausea, vomiting, fatigue, diarrhoea, muscle cramps
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Molecule Description

Donepezil is used to treat Alzheimer's dementia. This medicine works by inhibiting the action of the chemical acetylcholinesterase, which is responsible for breaking down a molecule called acetylcholine in the brain. This raises the brain levels of acetylcholine which is associated with memory and recollection. This medicine should only be used for adults older than 18 years of age. Avoid taking this medicine without consulting your doctor. The dose and duration of this medicine will be decided by your doctor as per your signs and symptoms.

Uses

Donepezil is used for the treatment of Alzheimer's dementia.

Contraindications

When should one not use Donepezil

  • If you are allergic to donepezil or any other ingredient of Donepezil.
  • If you are allergic to any piperidine derivatives.

Side effects

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Fatigue
  • Diarrhoea
  • Muscle cramps

Precautions and Warnings

Pregnancy

Pregnancy

Limited information is available on the safety of Donepezil during pregnancy. As a precautionary measure, do not use this medicine if you are pregnant.

Breast Feeding

Breast Feeding

There is limited information available regarding the excretion of Donepezil in breastmilk. To avoid any risks to the baby, do not use this medicine during breastfeeding.

Driving

Driving

Donepezil may influence your ability to drive. If you experience dizziness, tiredness or muscle cramps after taking this medicine, it is suggested that you do not drive.

Alcohol

Alcohol

Alcohol may affect how Donepezil works. Avoid alcohol while taking this medicine unless your doctor advises otherwise.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a heart disease.
  • You suffer from liver problems or kidney problems.
  • You have stomach or duodenal ulcers.
  • You have asthma or any other lung disease.
  • You experience seizures (fits) or convulsions.
  • You experience any involuntary or abnormal movements of the tongue, face or body.
  • You have low levels of magnesium or potassium in your blood.

Mode of Action

How Does It Work?

Donepezil acts by inhibiting a chemical in the brain called acetylcholinesterase that is responsible for breaking down a substance called acetylcholine. Acetylcholine helps you to remember things. This medicine increases the level of acetylcholine in the brain and thus treats the symptoms of dementia in people with Alzheimer's disease.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Donepezil works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
  • Care should particularly be taken if you are taking anti-fungals (ketoconazole, itraconazole), antibiotics (erythromycin, clarithromycin, rifampicin, levofloxacin, moxifloxacin), anti-depressants (fluoxetine, citalopram, escitalopram, amitriptyline), anti-convulsants (phenytoin, carbamazepine), pain-killers (aspirin, ibuprofen, diclofenac), anti-psychotics (pimozide, sertindole, ziprasidone), anti-cholinergics (tolterodine), medicines for a heart condition (quinidine, beta-blockers like propranolol and atenolol) or other Alzheimer's disease medication (galantamine).

Dosage

Overdose

Symptoms of overdose of Donepezil include severe nausea, vomiting, drooling and sweating. If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

You should never miss your dose of medicines. However, if you missed any dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

Frequently Asked Questions (FAQs)

The doctor will suggest you the best time of the day to take Donepezil depending on your condition, other medications that you take, food, and lifestyle habits.

Donepezil should be taken at the same dose and same frequency exactly as prescribed by your doctor. Your doctor will advise you on how long you should continue to take this medicine. Do not stop taking this medicine without consulting your doctor.

Your doctor will recommend whether you can take Donepezil if you are taking or have recently taken other medicines. Please inform your doctor about any other medicines that you are taking, including nonprescription medicines.

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