Donepezil
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Molecule Summary
| Uses | Alzheimer's dementia |
| Therapy | Drugs For Alzheimer Disease |
| Side Effects | Nausea, vomiting, fatigue, diarrhoea, muscle cramps |
Medicines
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Molecule Description
Donepezil is used to treat Alzheimer's dementia. This medicine works by inhibiting the action of the chemical acetylcholinesterase, which is responsible for breaking down a molecule called acetylcholine in the brain. This raises the brain levels of acetylcholine which is associated with memory and recollection. This medicine should only be used for adults older than 18 years of age. Avoid taking this medicine without consulting your doctor. The dose and duration of this medicine will be decided by your doctor as per your signs and symptoms.
Uses
Donepezil is used for the treatment of Alzheimer's dementia.
Contraindications
When should one not use Donepezil
- If you are allergic to donepezil or any other ingredient of Donepezil.
- If you are allergic to any piperidine derivatives.
Side effects
Common side effects of this drug are:
- Nausea
- Vomiting
- Fatigue
- Diarrhoea
- Muscle cramps
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a heart disease.
- You suffer from liver problems or kidney problems.
- You have stomach or duodenal ulcers.
- You have asthma or any other lung disease.
- You experience seizures (fits) or convulsions.
- You experience any involuntary or abnormal movements of the tongue, face or body.
- You have low levels of magnesium or potassium in your blood.
Mode of Action
How Does It Work?
Donepezil acts by inhibiting a chemical in the brain called acetylcholinesterase that is responsible for breaking down a substance called acetylcholine. Acetylcholine helps you to remember things. This medicine increases the level of acetylcholine in the brain and thus treats the symptoms of dementia in people with Alzheimer's disease.
Interactions
Interactions with other medicines
- Some medicines can affect the way Donepezil works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
- Care should particularly be taken if you are taking anti-fungals (ketoconazole, itraconazole), antibiotics (erythromycin, clarithromycin, rifampicin, levofloxacin, moxifloxacin), anti-depressants (fluoxetine, citalopram, escitalopram, amitriptyline), anti-convulsants (phenytoin, carbamazepine), pain-killers (aspirin, ibuprofen, diclofenac), anti-psychotics (pimozide, sertindole, ziprasidone), anti-cholinergics (tolterodine), medicines for a heart condition (quinidine, beta-blockers like propranolol and atenolol) or other Alzheimer's disease medication (galantamine).
Dosage
Overdose
Symptoms of overdose of Donepezil include severe nausea, vomiting, drooling and sweating. If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
You should never miss your dose of medicines. However, if you missed any dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.
Frequently Asked Questions (FAQs)
Articles
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References:
- Donepezil hydrochloride 10mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 12 June 2026].
- Donepezil Hydrochloride 10 mg Film-coated tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 12 June 2026].
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