Diacerein

Uses	Osteoarthritis
Therapy	Drugs For Osteoarthritis
Side Effects	Diarrhoea, stomach ache, discolouration of urine

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Molecule Description

Diacerein is a slow-acting medicine used for treating symptoms of osteoarthritis affecting the hip or knee. It belongs to the class of medicine known as anthraquinones.

Uses

Diacerein is used to relieve symptoms of osteoarthritis of the hip or knee.

Contraindications

When should one not use Diacerein

If you are allergic to diacerein or any other ingredient of this medicine.
If you have liver problems or undiagnosed stomach disorders.
If you are suffering from diseases of the intestine such as blockage in the intestine or ulcerative colitis or Crohn's disease.
If you are giving it to a child.
If you are pregnant or breastfeeding.

Side effects

Common side effects of this drug are:

Diarrhoea
Stomach ache
Discolouration of urine

Precautions and Warnings

Pregnancy

There is limited information available about the effect of Diacerein during pregnancy. Hence it is recommended to avoid the use of this medicine during pregnancy. Inform your doctor if you are pregnant, think you may be pregnant or plan a pregnancy.

Breast Feeding

There is limited information available about the effect of Diacerein on breastfeeding. Hence it is recommended to avoid the use of this medicine during breastfeeding. Consult your doctor.

Driving

There is limited information available on the effect of the medicine on the driving ability of an individual. So it is advised not to drive until you know how the medicine affects you.

Alcohol

Drinking alcohol along with Diacerein can increase the risk of liver damage. So it is important to consult your physician if you drink too often. It may be best to hold off on drinking alcohol until you have finished treatment.

Other General Warnings

Talk to your doctor if

You have or have a history of liver disease.
You experience diarrhoea after taking this medicine.
You are above 65 years of age, as old age can make you more prone to develop diarrhoea during the treatment. So it may require dose adjustment.
You are already taking any other medicines such as laxatives, diuretics etc.
You experience any symptoms associated with the liver. As it may cause an increase in liver enzymes and hepatitis. The doctor might ask you for liver tests.
You have an intolerance to any sugar.
You are pregnant or a breastfeeding woman.
You should avoid alcohol intake during the treatment as it may increase the risk of liver damage.

Mode of Action

How Does It Work?

Diacerein has anti-inflammatory properties and works by blocking chemicals causing inflammation and slowing down the breakdown of cartilage. Thus, relieves pain and swelling and improves joint function in osteoarthritis patients.

Interactions

Interactions with other medicines

Some medicines can affect the way Diacerein works or Diacerein itself can reduce the effectiveness of other medicines taken at the same time.
Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction. Also, you should inform your doctor if you have a planned surgery or vaccination scheduled.
Especially, if you are taking any heart-related medicines like digoxin or diuretics (or water pills). Simultaneous use of these medicines along with Diacerein, can increase the risk of heart rhythm disorder.
Avoid taking Diacerein along with antacids, as it may affect the activity of Diacerein. Keep a gap of at least 2 hours between these two medicines.

Dosage

Overdose

Symptoms of overdose may include diarrhoea. It is advised to have plenty of fluids and contact your doctor immediately or visit the nearest hospital. Also, carry the package of the medicine along with you for easy assessment of the severity of an overdose.

Missed a Dose

Take the missed dose when you remember but if it is time for the next dose then skip the missed dose. Do not take a double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Consult your doctor before taking Diacerein with omeprazole. Antacids can affect the activity of Diacerein, so keep a gap of at least 2 hours between Diacerein and antacids.

No, it is not a steroid. Diacerein belongs to the class of medicine known as anthraquinones.

Diacerein is used to relieve symptoms of osteoarthritis of the hip or knee. It decreases pain and improves joint function in osteoarthritis patients.

No. Abruptly discontinuing the treatment with Diacerein may worsen the osteoarthritis condition. You should continue the treatment even if you do not have symptoms and still complete the prescribed duration.

You need to take Diacerein as long as a doctor has prescribed it to you. It is usually prescribed for a long duration in order to get maximum benefit.

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Diacerein

Molecule Summary