Clonazepam
Description
Clonazepam is a prescription medicine used to treat epilepsy and anxiety. Epile
psy is a nervous system disorder that causes sudden, jerky, and uncontrolled body movements due to abnormal electrical discharges in the brain. Clonazepam works by calming overactive nerves in the brain, helping to stop seizures and prevent them from recurring. It is also effective in reducing anxiety symptoms such as restlessness, uneasiness, and fear, allowing patients to feel more relaxed and at ease. While Clonazepam is highly effective, it may cause side effects like sleepiness, dizziness, loss of concentration, poor coordination, or low mood. If any of these symptoms occur, seek medical advice promptly. This medicine should be used with caution in people with liver disease, kidney disease, or during pregnancy, and it must not be taken with alcohol. Since Clonazepam is habit-forming, it should only be used under medical supervision and exactly as prescribed by your doctor to ensure safe and effective treatment.
Uses
- Used to treat epilepsy and seizures, helping to control sudden, jerky, and uncontrolled body movements.
- Helps manage anxiety disorders, reducing restlessness, nervousness, and excessive worry.
- It may also be used to prevent future episodes of seizures or reduce the frequency of panic attacks.
Contraindications
When should one not use Clonazepam
- If you have liver disease, Clonazepam should be avoided or used only under strict medical supervision.
- If you have kidney disease, inform your doctor before using Clonazepam, as dose adjustment may be required.
- If you have breathing difficulty or chronic obstructive pulmonary disease (COPD), use of Clonazepam may worsen respiratory problems and should be taken with caution.
- If you are suffering from glaucoma, especially narrow-angle glaucoma, Clonazepam is contraindicated and should not be used.
- If you have had a skin rash, allergy, or hypersensitivity reaction with prior use of this medication or similar medicines, avoid Clonazepam and seek medical advice.
Side effects
Common side effects of this drug are:
- Sleepiness
- Dullness
- Lack of concentration
- Irritability
- Impaired coordination
- Dizziness
- Depression
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have or develop symptoms of depression, mood changes, suicidal thoughts, or unusual changes in behaviour.
- You have liver disease, since clonazepam is metabolised in the liver, and impairment may increase side effects.
- You have kidney problems because metabolites are excreted through the kidneys, and accumulation may occur.
- You have chronic respiratory conditions such as asthma or COPD, as clonazepam may worsen breathing difficulties.
- You are pregnant, planning pregnancy, or of childbearing potential, because clonazepam can pose risks to the fetus.
- You are breastfeeding, since clonazepam can pass into breast milk.
- You are elderly, and reduced liver, kidney, or heart function may require careful dose adjustment.
- Before stopping clonazepam suddenly, consider avoiding withdrawal symptoms or worsening seizures.
- You are taking other medications, supplements, or herbal products that can cause drowsiness or depress the nervous system, as these interactions may increase the risk.
Interactions
Interactions with other medicines
- Other benzodiazepines or anti-epileptics like lorazepam, diazepam, and clobazam can increase sedation and breathing difficulties.
- Anti-anxiety medicines such as alprazolam and chlordiazepoxide may cause excessive drowsiness and central nervous system depression.
- Antidepressants, especially tricyclics like amitriptyline and clomipramine, can worsen depression and sedation.
- Opioid painkillers, including morphine, oxycodone, and tramadol, carry a high risk of severe drowsiness and breathing problems.
- Alcohol and antihistamines can further enhance sedation and impair alertness.
Content Details

Ravindra Ghongade
B. Pharm

Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What is Clonazepam used for?
Q: How does Clonazepam work?
- Clonazepam works by enhancing the effect of a natural chemical in the brain called gamma-aminobutyric acid (GABA). This calming effect slows down brain activity, which helps control seizures, reduce panic attacks, and ease anxiety or involuntary movements....
Q: What are the common side effects of Clonazepam?
- Common side effects include drowsiness, dizziness, fatigue, muscle weakness, and coordination problems. Some people may also experience memory issues, confusion, or mood changes. Serious but rare side effects include breathing difficulties, severe allergic reactions, or worsening depression....
References
- Roche Labs Inc. Klonopin (clonazepam) Tablets: Prescribing Information [Internet]. South San Francisco (CA): Roche Labs; October 2013 [cited 2025 Sep 17].
- WebMD LLC. Klonopin (clonazepam) – Drug monograph [Internet]. Medscape; [cited 2025 Sep 17].
- Central Drugs Standard Control Organization (CDSCO). List of New Drugs Approved in the Year 2025 Till Date [Internet]. New Delhi: CDSCO; [cited 2025 Sep 17].