Clobetasol+Calcipotriol / Calcipotriene
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Molecule Summary
| Uses | Psoriasis |
| Therapy | Drugs For Psoriasis |
| Side Effects | Itchy skin, skin rash, skin irritation, dry skin |
Medicines
available
19k pincodes
Molecule Description
Clobetasol+Calcipotriol / Calcipotriene is a topical medication commonly used to treat psoriasis, a skin condition characterized by red, itchy, scaly patches. It helps reduce discomfort, improve skin appearance, and control flare-ups when used regularly as prescribed. It is intended for external use only and should be applied in a thin layer to the affected areas only.
This medicine is usually advised to be used exactly as directed by your doctor or pharmacist. Hands should be washed before and after application, and care should be taken to avoid contact with the eyes, mouth, or healthy skin. The treated area should not be covered with bandages unless advised, and it should not be used for longer durations or on larger areas than recommended.
Clobetasol+Calcipotriol / Calcipotriene works through the combined action of its two active components. Clobetasol is a potent topical steroid that reduces redness, swelling, and itching by modulating inflammatory processes in the skin. In contrast, calcipotriol, a vitamin D-like compound, slows the excessive growth of skin cells that leads to scaling in psoriasis. Together, they help relieve symptoms and improve skin healing.
Some people may experience mild side effects, such as itching, irritation, dryness, or a rash at the site of application, which are usually transient. If severe irritation, allergic reactions, vision problems, or signs of infection occur, the medicine should be stopped, and medical advice should be sought. It is not recommended for children and should be used cautiously in people with conditions like diabetes or calcium imbalance.
Clobetasol+Calcipotriol / Calcipotriene should be stored in a cool, dry place away from direct heat and sunlight, and kept out of reach of children and pets. It should not be frozen or used after expiry. If a dose is missed, it should be applied when remembered without overapplying. Regular follow-up with your doctor is important, especially if there is no improvement after two weeks of use.
Uses
Clobetasol+Calcipotriol / Calcipotriene is used to treat a skin condition called psoriasis (a condition that causes your skin to become red, itchy, scaly patches).
Contraindications
When should one not use Clobetasol+Calcipotriol / Calcipotriene
- If you are allergic to Clobetasol, Calcipotriol or any of the ingredients in Clobetasol+Calcipotriol / Calcipotriene.
- If your doctor has told you that you have problems with your calcium levels.
- If you have problems with your liver or kidneys.
- If you are suffering from any other skin infections.
- If you have acne, ulcers or broken skin.
Side effects
Common side effects of this drug are:
- Itchy skin
- Skin rash
- Skin irritation, dry skin (uncommon)
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You experience any allergic skin reactions after using Clobetasol+Calcipotriol / Calcipotriene.
- You develop other infections or skin reactions after applying this medicine.
- You have diabetes.
- You experience any problems with your eyesight, such as blurred vision, while on treatment.
- You are also applying other topical medications (creams, ointments, lotions, etc.).
- You do not notice any improvement in your condition after applying Clobetasol+Calcipotriol / Calcipotriene for two weeks.
- You are receiving ultraviolet radiation treatment because this medication should be used with caution.
- If your eyes come into contact with this medicine, rinse them immediately with clean water.
- Do not use this medicine for any condition other than that prescribed by the doctor.
- Do not apply this medicine for an extended period, to a larger skin area, or for longer than the prescribed duration.
- Do not stop using this medicine before you complete the treatment.
- Clobetasol+Calcipotriol / Calcipotriene is not recommended for use in children.
Mode of Action
How Does It Work?
- Clobetasol+Calcipotriol / Calcipotriene works through the combined action of its components, Clobetasol and Calcipotriol.
- Clobetasol is a steroid that works by blocking the production of certain chemical substances in the body (prostaglandins) that cause itching, swelling, and redness.
- Calcipotriol is similar to vitamin D and works by reducing the growth of skin cells, thereby decreasing your symptoms.
Interactions
Interactions with other medicines
- Clobetasol+Calcipotriol / Calcipotriene is applied externally on the skin; thus, it is less likely to interact with other medicines taken orally. However, it may interact with other topically applied creams, lotions, and gels. Consult your doctor if you are already using another topical gel or cream.
- Medicines like ritonavir (used in HIV infection), itraconazole (used to treat fungal infections) should be used with caution along with Clobetasol+Calcipotriol / Calcipotriene.
Dosage
Overdose
- As Clobetasol+Calcipotriol / Calcipotriene is intended for external use, overdose cases are unlikely. If you have overapplied it, wipe out the excess medicine with a tissue or cotton.
- However, excessive use of this medicine for a longer period may lead to steroid toxicity, increased calcium levels, and coma, causing symptoms like muscle weakness, constipation, and confusion.
- In case of accidental ingestion, contact your physician immediately or visit the nearest hospital.
Missed a Dose
If you have missed applying Clobetasol+Calcipotriol / Calcipotriene, apply it as soon as you remember. Do not overapply this medicine just to compensate for the missed application.
Frequently Asked Questions (FAQs)
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References:
- GlaxoSmithKline UK. Dermovate Cream (clobetasol propionate): Summary of Product Characteristics [Internet]. UK: Datapharm Ltd.; last updated 15 Jul 2024 [cited 2026 Jun 9].
- Leo Laboratories Ltd. Dovonex® Ointment (calcipotriol) — Summary of Product Characteristics [Internet]. UK: Datapharm Ltd.; last updated 27 Jul 2023 [cited 2026 Jun 9].
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