Tranexamic Acid+Mefenamic Acid

When should one not use Tranexamic Acid+Mefenamic Acid

• If you are allergic to tranexamic acid, mefenamic acid or similar medicines
• If you have problems with your heart, liver or kidney
• If you recently had a bypass surgery of the heart
• If you have a history of stomach or intestinal bleeding due to painkillers
• If you have or have ever had a blood clot in your blood vessels
• If you have a bleeding disorder called consumption coagulopathy
• If you have a history of fits or inflammatory bowel disease
• Tranexamic acid+Mefenamic acid should not be taken in the last trimester of pregnancy

Common side effects of this drug are:

• Headache
• Nausea
• Back pain
• Constipation
• Diarrhoea
• Muscle pain

Other General Warnings

• You have any medical history especially of bleeding in the brain or history of blood clots
• You are suffering from any type of heart disease or blood clotting disorder.
• You have problems with your kidney
• You are suffering from any respiratory disorders such as asthma.
• You experience visual disturbances after taking tranexamic acid+mefenamic acid
• You have fits
• You are taking oral contraceptives
• You have an irregular menstrual bleeding pattern that is not treated.
• You are passing blood in the urine.
• You are an elderly person
• Tranexamic acid+Mefenamic acid can impair your fertility. Thus, you should not take this medicine if you are trying to conceive or taking treatment of fertility.

How Does It Work?

• Tranexamic acid works by improving the blood clotting by preventing or slowing down the process of break down of blood clots called fibrinolysis.
• Mefenamic acid helps in relieving the sensation of pain by inhibiting the formation of inflammatory mediators such as prostaglandin which is responsible for pain and swelling.

Interactions with other medicines

• Some medicines can affect the way Tranexamic acid+Mefenamic acid works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
• Medicines used to thin blood such as Warfarin should be used with caution as there are chances of increased bleeding upon long-term use.
• Anti-platelet medicines such as Aspirin or Clopidogrel, steroids and painkillers when taken along can induce stomach or intestinal bleeding.
• Methotrexate and lithium should not be taken along with this medicine as there are chances of toxicity of former medicines.
• Antidiabetic medicine if taken along with this medicine can lead to low blood glucose.
• Tranexamic acid+Mefenamic acid should not be taken for 8 to 12 days after taking a medicine called Mifepristone.
• Digoxin used to treat heart failure should not be taken along with this medicine.
• Medicines used to lower blood pressure such as water pills, immunomodulator medicines such as Tacrolimus, Ciclosporin, anti-HIV medicines such as Zidovudine, Probenecid and certain antibiotics should be used cautiously.
• Other painkillers or anti-inflammatory medicines should be used with caution along with this medicine.