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Molecule Description

Hydroquinone+Mometasone+Tretinoin is a combination medicine. It is used to trea

t moderate to severe melasma. It is used to lighten the skin tone or appearance, especially when there is dark pigmentation. Melasma is a skin condition that causes dark and discoloured patches on the skin. Hydroquinone+Mometasone+Tretinoin is available in the form of cream, gel, ointment, soap.


Uses of Hydroquinone+Mometasone+Tretinoin

  • Hydroquinone+Mometasone+Tretinoin is used for the short-term treatment of moderate-to-severe melasma (dark and discoloured patches on the skin).
  • It is also used to lighten the skin tone or appearance and dark spots or age spots in older people due to exposure to the sun.

Contraindications of Hydroquinone+Mometasone+Tretinoin

When should one not use Hydroquinone+Mometasone+Tretinoin

  • If you are allergic to hydroquinone, mometasone, tretinoin or similar medicines.
  • If you have a skin tumour or a family history of skin tumour.
  • If you suffer from any skin conditions like eczema (infected skin due to allergy), rosacea (small red pustules on the face), rashes around the mouth or damaged skin anywhere in the body.
  • If you need to be exposed to the sun for prolonged periods.
  • If you have any viral or fungal infections of the skin, have ulcers on the skin or are having tuberculosis.

Side effects of Hydroquinone+Mometasone+Tretinoin

Common side effects of this drug are:

Application site reactions like burning sensation, itching, irritation, redness.

Precautions and Warnings of Hydroquinone+Mometasone+Tretinoin



Can I use hydroquinone+mometasone+tretinoin during pregnancy?
Hydroquinone+Mometasone+Tretinoin should not be used during pregnancy or if you are planning to conceive, consult your doctor before using it.

Breast Feeding

Can I use hydroquinone+mometasone+tretinoin while breastfeeding?
Hydroquinone+Mometasone+Tretinoin is not recommended while breastfeeding as there is limited safety data is available.


Can I drive if I have used hydroquinone+mometasone+tretinoin?
The use of hydroquinone+mometasone+tretinoin may not affect your driving ability.


Can I consume alcohol with hydroquinone+mometasone+tretinoin?
There are no known interactions of hydroquinone+mometasone+tretinoin with alcohol.

Other General Warnings

Talk to your doctor if
  • You have a history of allergic reactions.
  • You develop skin rashes or infections after using hydroquinone+mometasone+tretinoin.
  • You are a pregnant woman or a breastfeeding mother.
  • You have diabetes or have Cushing's syndrome (symptoms may include weight gain, moon face, purple patches on the skin).
  • Avoid unnecessary or prolonged exposure to sunlight or UV light and wear protective clothing and sunscreen.

Mode of Action of Hydroquinone+Mometasone+Tretinoin

How Does It Work?

  • Hydroquinone works by inhibiting an enzyme (tyrosinase) responsible for producing a pigment called melanin. Melanin is responsible for skin pigmentation and melasma.
  • Tretinoin is a metabolite of vitamin A and has anti-inflammatory properties. It is responsible for the elimination of melanin that has been formed.
  • Mometasone is a steroid and works by blocking the production of inflammatory chemicals like prostaglandins and leukotrienes. Mometasone narrows and constricts blood vessels, which are dilated (widened...
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Interactions of Hydroquinone+Mometasone+Tretinoin

Interactions with other medicines

  • Some medicines can affect the way hydroquinone+mometasone+tretinoin works or this medicine itself can reduce the effectiveness of other medicines taken at the same time. Tell your doctor about all the...
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Dosage of Hydroquinone+Mometasone+Tretinoin


Seek urgent medical help if you suspect an overdose.

Missed a Dose

If you have missed to use hydroquinone+mometasone+tretinoin, use it as soon as possible. Do not over use it just to compensate for the missed dose.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What is hydroquinone+mometasone+tretinoin used for?

A: Hydroquinone+Mometasone+Tretinoin is used for short term intermittent treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreen.

Q: In which all dosage forms is hydroquinone+mometasone+tretinoin available?

A: Hydroquinone+Mometasone+Tretinoin is available in the form of cream, gel, ointment, soap.
Last Updated on: 26 Oct 2021 | 10:06 PM (IST)

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